rs9939609, FTO

N. diseases: 74
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE Only three of the 16 polymorphisms studied showed significant association with MS; rs9939609 of the FTO gene confers risk for MS (odds ratio [OR]: 1.73, 95% CI: 1.07-2.78, p = 0.026), while rs1137101 of the LEPR gene (OR: 0.47, 95% CI: 0.28-0.80, p = 0.005) and rs1801133 of the MTHFR gene (OR: 0.59, 95% CI: 0.35-0.99, p = 0.049) are protective against MS. 24624915 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE The Fat Mass and Obesity-Associated Protein (FTO) gene rs9939609 single nucleotide polymorphism (SNP) has been associated with obesity, metabolic syndrome, insulin resistance (IR), and type 2 diabetes mellitus in the general population. 25367448 2015
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients. 23490278 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE In conclusion, FTO rs9939609 was associated with obesity measures, especially in those with the MetS, which was further exacerbated by high dietary SFA intake at baseline and 7.5 y later. 22457394 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. 21749608 2011
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134 2009
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.070 GeneticVariation BEFREE Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. 18339204 2008