rs9939609, FTO

N. diseases: 98
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE BACKGROUND The distribution of fat mass and obesity-associated gene (FTO) genes rs9939609 and rs1421085 in obese and normal ethnic Mongolians was analyzed to investigate the association of FTO gene polymorphisms with obesity and metabolic syndrome in ethnic Mongolians. 30442880 2018
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS. 29193419 2018
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The present study shows for first time that FTO gene rs9939609 is genetic risk factor for metabolic syndrome in Egyptian population which may help in understanding the biology of this complex syndrome and highlighted that this association may be through HDL-C component. 28915859 2017
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Genotype distribution of the variant rs9939609 was different between MetS and controls (P = 0.017). 26741700 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The FTO rs9939609 polymorphism was associated with anthropometric parameters and metabolic syndrome in the younger age group (25-44 years) and in individuals having low level of physical activity. 27003669 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE DNA was extracted from the whole blood of 192 natural postmenopausal women (40 to 65 years) screened for the METS and tested for three gene SNPs related to obesity: the fat mass obesity (FTO: rs9939609) and the methylenetetrahydrofolate reductase (MTHFR: C677T and A1298C). 26902996 2016
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Only three of the 16 polymorphisms studied showed significant association with MS; rs9939609 of the FTO gene confers risk for MS (odds ratio [OR]: 1.73, 95% CI: 1.07-2.78, p = 0.026), while rs1137101 of the LEPR gene (OR: 0.47, 95% CI: 0.28-0.80, p = 0.005) and rs1801133 of the MTHFR gene (OR: 0.59, 95% CI: 0.35-0.99, p = 0.049) are protective against MS. 24624915 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The Fat Mass and Obesity-Associated Protein (FTO) gene rs9939609 single nucleotide polymorphism (SNP) has been associated with obesity, metabolic syndrome, insulin resistance (IR), and type 2 diabetes mellitus in the general population. 25367448 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Furthermore, the FTO rs9939609 genotype accounted for 21.3% of the MetS phenotype together with total cholesterol, BMR and age. 24675148 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The FTO gene polymorphism (rs9939609) was found to be associated with increased insulin resistance, insulin and triglyceride levels in obese females with TT variant and without metabolic syndrome. 23490278 2014
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE This association remains after excluding rs9939609, a SNP that was frequently reported to have strong association with obesity and MetS. 22189543 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE In conclusion, FTO rs9939609 was associated with obesity measures, especially in those with the MetS, which was further exacerbated by high dietary SFA intake at baseline and 7.5 y later. 22457394 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Our results suggested that FTO rs9939609</span> polymorphism was significantly associated with the increased risk of MetS in European and Asian populations. 22311015 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The rs9939609 polymorphism was not associated with MetS, elevated waist circumference or BMI, or diabetic complications. 21741858 2012
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE The minor allele of rs9939609 (FTO), rs7903146 (TCF7L2), C56G (APOA5), T1131C (APOA5), C482T (APOC3), C455T (APOC3) and 174G>C (IL6) were more prevalent in subjects with MetS, whereas the minor allele of Taq-1B (CETP) was less prevalent in subjects with the MetS. 21749608 2011
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Four SNPs in the FTO gene were significantly related to metabolic syndrome: rs9939609 (P=0.00013), rs8050136 (P=0.00011), rs1558902 (P=6.6 × 10(-5)) and rs1421085 (P=7.4 × 10(-5)). rs3764220 in the SCG3 gene (P=0.0010) and rs2293855 in the MTMR9 gene (P=0.0015) were also significantly associated with metabolic syndrome. 21796137 2011
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples. 18339204 2008
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.100 GeneticVariation BEFREE Polymorphisms in TCF7L2 (rs7903146, OR 1.10, 95% CI 1.04-1.17, p = 0.00097), FTO (rs9939609, OR 1.08, 95% CI 1.02-1.14, p = 0.0065), WFS1 (rs10010131, OR 1.07, 95% CI 1.02-1.13, p = 0.0078) and IGF2BP2 (rs4402960, OR 1.07, 95% CI 1.01-1.13, p = 0.021) predicted the development of at least three components of the metabolic syndrome in both univariate and multivariate analysis; in the case of TCF7L2, WFS1 and IGF2BP this was due to their association with hyperglycaemia (p < 0.00001, p = 0.0033 and p = 0.027, respectively) and for FTO it was due to its association with obesity (p = 0.004). 18853134 2008