Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4624
Gene Symbol: MYH6
MYH6
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. 1703406

1991
Entrez Id: 4625
Gene Symbol: MYH7
MYH7
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Changes in myosin and creatine kinase mRNA levels with cardiac hypertrophy and hypothyroidism. 1703406

1991
Entrez Id: 3675
Gene Symbol: ITGA3
ITGA3
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Expression of collagen binding integrins during cardiac development and hypertrophy. 1835909

1991
Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.510 ModifyingMutation RGD Endothelin-1 and its binding sites are upregulated in pressure overload cardiac hypertrophy. 7771559

1995
Entrez Id: 7436
Gene Symbol: VLDLR
VLDLR
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Regulation of very-low-density lipoprotein receptor in hypertrophic rat heart. 8603509

1996
Entrez Id: 7079
Gene Symbol: TIMP4
TIMP4
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Temporal regulation of extracellular matrix components in transition from compensatory hypertrophy to decompensatory heart failure. 10067796

1999
Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Involvement of receptor-type tyrosine kinase gene families in cardiac hypertrophy. 10489112

1999
Entrez Id: 302
Gene Symbol: ANXA2
ANXA2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Pressure overload induces overexpression of annexins II and V in aortic-banded rats. 10603972

1998
Entrez Id: 308
Gene Symbol: ANXA5
ANXA5
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Pressure overload induces overexpression of annexins II and V in aortic-banded rats. 10603972

1998
Entrez Id: 27063
Gene Symbol: ANKRD1
ANKRD1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Cardiac ankyrin repeat protein is a novel marker of cardiac hypertrophy: role of M-CAT element within the promoter. 10904011

2000
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.230 Biomarker RGD [Dynamic changes of angiotensin II type-1 receptor mRNA expression in volume-overloaded ventricular hypertrophy]. 11324571

1998
Entrez Id: 1901
Gene Symbol: S1PR1
S1PR1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. 11549339

2001
Entrez Id: 5159
Gene Symbol: PDGFRB
PDGFRB
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Role of platelet-derived growth factor receptor-mediated signal transduction in myocardial hypertrophy of spontaneously hypertensive rats. 11973598

2002
Entrez Id: 1827
Gene Symbol: RCAN1
RCAN1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Direct biomechanical induction of endogenous calcineurin inhibitor Down Syndrome Critical Region-1 in cardiac myocytes. 12124198

2002
Entrez Id: 9464
Gene Symbol: HAND2
HAND2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker RGD HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. 12359233

2002
Entrez Id: 9421
Gene Symbol: HAND1
HAND1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. 12359233

2002
Entrez Id: 2
Gene Symbol: A2M
A2M
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Direct injection and expression in vivo of full-length cDNA of the cardiac isoform of alpha-2 macroglobulin induces cardiac hypertrophy in the rat heart. 12494268

2003
Entrez Id: 6271
Gene Symbol: S100A1
S100A1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD The myocardial protein S100A1 plays a role in the maintenance of normal gene expression in the adult heart. 12619862

2003
Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker RGD Differential induction of protein kinase C isoforms at the cardiac hypertrophy stage and congestive heart failure stage in Dahl salt-sensitive rats. 12887134

2003
Entrez Id: 4830
Gene Symbol: NME1
NME1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Plasma membrane-associated nucleoside diphosphate kinase (nm23) in the heart is regulated by beta-adrenergic signaling. 14559858

2003
Entrez Id: 5837
Gene Symbol: PYGM
PYGM
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. 14618266

2003
Entrez Id: 10699
Gene Symbol: CORIN
CORIN
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.210 Biomarker RGD Upregulation of corin gene expression in hypertrophic cardiomyocytes and failing myocardium. 15191894

2004
Entrez Id: 10965
Gene Symbol: ACOT2
ACOT2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. 15292030

2004
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.200 Biomarker RGD Differential expression of cytokines in the rat heart in response to sustained volume overload. 15542404

2004