LEGAL NOTICES

The DisGeNET database and Knowledge discovery platform are provided to advance the knowledge about human diseases and their associated genes, and are intended to be used only for research and education.

  1. Database License
  2. The DisGeNET database is made available under the Attribution-NonCommercial-ShareAlike 4.0 International License whose text can be found here. If DisGeNET is incorporated into other works, we ask that DisGeNET is properly cited (see the citation guidelines ), and that the version number of DisGeNET is clearly displayed.

  3. Cytoscape App License
  4. The DisGeNET app is distributed under the GNU GPL 3.0 license. More details about the GNU General Public License 3.0 is available here.

  5. Citation Requirements and Guidelines
  6. The DisGeNET database use is subject to appropriate acknowledgement. Please follow our citation guidelines.

  7. NLM Use Terms
  8. Data from the U.S. National Library of Medicine (NLM) are provided pursuant to the following terms:

    NLM represents that its data were formulated with a reasonable standard of care. Except for this representation, NLM makes no representation or warranties, expressed or implied. This includes, but is not limited to, any implied warranty of merchantability or fitness for a particular purpose, with respect to the NLM data, and NLM specifically disclaims any such warranties and representations. In the current version of DisGeNET database a static version of the MEDLINE®/PubMed® data downloaded on the February 25th 2014, is integrated. Therefore, be aware that the DisGeNET database and Cytoscape plugin do not reflect the most current biomedical/scientific data available from NLM.

    NLM databases are produced by a U.S. Government agency and as such are not protected by US copyright laws. Use of the databases outside the United States may be governed by applicable foreign copyright laws.

    NLM assumes no responsibility or liability associated with use of copyrighted material, including transmitting, reproducing, redistributing, or making commercial use of the data. NLM does not provide legal advice regarding copyright, fair use, or other aspects of intellectual property rights. Persons contemplating any type of transmission or reproduction of copyrighted material such as abstracts are advised to consult legal counsel.

    All complete or parts of NLM-derived records that are redistributed or retransmitted must be identified as being derived from NLM databases. Examples are: "From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine." and "MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine."

    Some material in the NLM databases derives from copyrighted publications. Publishers and/or authors often claim copyright on the abstracts in MEDLINE®/PubMed®. Refer to the publication data appearing in the citations, as well as to the copyright notices appearing in the original publications, all of which are hereby incorporated by reference. Users of the NLM databases are solely responsible for compliance with fair use guidelines and applicable copyright restrictions. Users should consult legal counsel before using NLM-produced records to be certain that their plans are in compliance with appropriate laws.

  9. UMLS® Metathesaurus® Use Terms
    • UMLS® Metathesaurus® data is used under the terms of the UMLS® Metathesaurus® license.

  10. Acknowledgments to original resources
  11. DisGeNET is a derivative database that integrates gene-disease associations from several public expert curated data sources and text-mining derived associations. We would like to acknowledge all the data sources from where the data are derived:

    • CLINGEN: the Clinical Genome Resource, dedicated to building an authoritative central resource that defines the clinical relevance of genes and variants for use in precision medicine and research.
    • CTD: CTDTM or Comparative Toxicogenomics DatabaseTM contains manually curated information about gene-disease relationships with focus on understanding the effects of environmental chemicals on humans health.
    • GENOMICS_ENGLAND panel app: a publically-available knowledgebase that allows virtual gene panels related to human disorders to be created, stored and queried. /li>
    • GWAS Catalog: The GWAS Catalog is provided jointly by the National Human Genome Research Institute (NHGRI) and the European Bioinformatics Institute (EMBL-EBI). The Catalog is a quality controlled, manually curated, literature-derived collection of all published genome-wide association studies assaying at least 100,000 SNPs and all SNP-trait associations with p-values < 1.0 x 10-5.
    • GNOMAD: or the Genome Aggregation Database is a resource that aggregats and harmonizes both exome and genome sequencing data from a wide variety of large-scale sequencing projects.
    • HDO: The Disease Ontology has been developed as a standardized ontology for human disease with the purpose of providing the biomedical community with consistent, reusable and sustainable descriptions of human disease terms, phenotype characteristics and related medical vocabulary disease concepts through collaborative efforts of researchers at Northwestern University, Center for Genetic Medicine and the University of Maryland School of Medicine, Institute for Genome Sciences.
    • HPO: The Human Phenotype Ontology (HPO) developed by the Human Phenotype Ontology Consortium aims to provide a standardized vocabulary of phenotypic abnormalities encountered in human disease. Terms in the HPO describes a phenotypic abnormality, such as atrial septal defect.
    • CGI: The Cancer Genome Interpreter is a tool that identifies known oncogenic alterations, predicts potential drivers among those of unknown significance and identify alterations in the tumor known to affect the response to anti-cancer drugs
    • GWASDB: The GWASdb provides comprehensive data curation and knowledge integration for GWAS significant trait/disease associated SNPs
    • MEDLINE: Gene-disease associations and sentences shown in the DisGeNET Web interface services are from MEDLINE®/PubMed®, a database of NLM or the U.S. National Library of Medicine. MEDLINE® is the NLM premier bibliographic database that contains journal citations and abstracts for biomedical literature from around the world. PubMed® provides free access to MEDLINE® and links to full text articles when possible. A proportion of the human gene-disease associations contained in DisGeNET were derived from MEDLINE®, by means of text mining approaches (Bundschus et al, 2008) and the BeFree System.
    • MGD: MGD or the Mouse Genome Database, at The Jackson Laboratory, Bar Harbor, Maine, is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. MGD strives to provide an extensively integrated information resource with experimental details annotated from both literature and on-line genomic data sources. MGD curates and presents the consensus representation of genotype (sequence) to phenotype information including highly detailed information about genes and gene products.
    • NCBI ClinVar: ClinVar, a database of the U.S. National Library of Medicine, is a freely accessible, public archive of reports of the relationships among human variations and phenotypes, with supporting evidence.
    • NCBI Gene: NCBI Gene, a database of the U.S. National Library of Medicine, integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    • NLM: NLM or the U.S. National Library of Medicine represents that its data were formulated with a reasonable standard of care. Except for this representation, NLM makes no representation or warranties, expressed or implied. This includes, but is not limited to, any implied warranty of merchantability or fitness for a particular purpose, with respect to the NLM data, and NLM specifically disclaims any such warranties and representations.
    • RGD: RGD or the Rat Genome Database, at the Medical College of Wisconsin, is the premier site for genetic, genomic, phenotype, and disease data generated from rat research.
    • Orphanet: an online rare disease and orphan drug data base (© INSERM 1997) is the reference portal for information on rare diseases and orphan drugs, for all audiences. Orphanet's aim is to help improve the diagnosis, care and treatment of patients with rare diseases. Available on http://www.orpha.net. Accessed on January 25, 2016.
    • UMLS: UMLS® or Unified Medical Language System®, a database of the U.S. National Library of Medicine, is a set of files and software that brings together many health and biomedical vocabularies and standards to enable interoperability between computer systems.
    • UniProt: UniProtKB/Swiss-Prot is one of the two sections of UniProt Knowledgebase (UniProtKB). This database contains manually curated information about protein sequence, structure and function. Moreover, it provides information on the functional effect of sequence variants and their association to disease.
    • dbSNP, the NCBI Short Genetic Variations database a catalog of short variations in nucleotide sequences from a wide range of organisms.

    DisGeNET RDF is a semantic formal representation of the DisGeNET content. We would like to acknowledge all the set of terminologies and ontologies that provide us the proper classes and relations to stablish data semantics:

    • NCBO: NCBO or the National Center for Biomedical Ontology is a center funded by the National Institutes of Health (NIH) and is part of the network of National Centers for Biomedical Computing. The goal of the National Center for Biomedical Ontology is to support biomedical researchers in their knowledge-intensive work, by providing online tools and a Web portal enabling them to access, review, and integrate disparate ontological resources in all aspects of biomedical investigation and clinical practice.
    • NCIt: NCTt or National Cancer Institute thesaurus, at the National Institutes of Health, provides reference terminology for many NCI and other systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.
    • SIO: SIO or the Semanticscience Integrated Ontology, is an ontology to facilitate biomedical knowledge discovery and it provides foundational support for the Bio2RDF project. SIO is implemented as an OWL-DL ontology that provides a simple, integrated ontology of types and relations for rich description of objects, processes and their attributes.
    • DCMI Metadata terms: DCMI Metadata terms or Dublin Core® Metadata Initiative Metadata Terms, are all metadata terms maintained by the Dublin Core Metadata Initiative. The Dublin Core Metadata Initiative, or "DCMI", is an open organization supporting innovation in metadata design and best practices across the metadata ecology. DCMI's activities include work on architecture and modeling, discussions and collaborative work in DCMI Communities and DCMI Task Groups, global conferences, meetings and workshops, and educational efforts to promote widespread acceptance of metadata standards and best practices. DCMI maintains a number of formal and informal liaisons and relationships with standards bodies and other metadata organizations.
    • HPO: The Human Phenotype Ontology (HPO) developed by the Human Phenotype Ontology Consortium aims to provide a standardized vocabulary of phenotypic abnormalities encountered in human disease. Terms in the HPO describes a phenotypic abnormality, such as atrial septal defect.

  12. Third Party Content, Web Sites, Products and Services
  13. Be aware that part of the content integrated in the DisGeNET database comes from third parties licensed data, and respective copyright holders retain rights for reproduction, redistribution and reuse. The IBI group cannot provide unrestricted permission regarding the use of the data, as some data may be covered by patents or other rights. Users of the DisGeNET database are solely responsible for compliance with fair use guidelines and applicable license/copyright restrictions imposed by the content providers. Users should carefully read these licenses before re-distributing any content in any type of application as there may be additional restrictions, permissions or copyright considerations imposed by the content providers. Users must contact the DisGeNET content providers regarding any use that is not covered by their licenses. Users should consult legal counsel before using DisGeNET database-produced records to be certain that their plans are in compliance with appropriate laws in your jurisdiction.

    The Site provides links to Web sites and access to content, products and services from third parties. By using DisGeNET, you agree that we are not responsible for the availability of, and content provided on, third party Web sites. You agree that we are not responsible for the quality of third party products or services. You agree that we are not responsible for any loss or damage of any sort you may incur from dealing with any third party.

  14. Disclaimer
  15. Except where expressly provided otherwise, the site, and all content, materials, information, software, products and services provided on the site, are provided on an "as is" and "as available" basis. The IBIgroup expressly disclaims all warranties of any kind, whether express or implied, including, but not limited to, the implied warranties of merchantability, fitness for a particular purpose and non-infringement. The IBI group makes no warranty that:

      a. the site will meet your requirements
      b. the site will be available on an uninterrupted, timely, secure, or error-free basis (though IBI will undertake best-efforts to ensure continual uptime and availability of its content)
      c. the results that may be obtained from the use of the site or any services offered through the site will be accurate or reliable
      d. the quality of any products, services, information, or other material obtained by you through the site will meet your expectations

    Any content, materials, information or software downloaded or otherwise obtained through the use of the site is done at your own discretion and risk. The IBI group shall have no responsibility for any damage to your computer system or loss of data that results from the download of any content, materials, information or software. The IBI group reserves the right to make changes or updates to the site at any time without notice.

  16. Limitation of liability
  17. In no event shall the IBI group be liable for any direct, indirect, incidental, special or consequential damages, or damages for loss of profits, revenue, data or use, incurred by you or any third party, whether in an action in contract or tort, arising from your access to, or use of, the site. Some jurisdictions do not allow the limitation or exclusion of liability. Accordingly, some of the above limitations may not apply to you. The IBI group assume no responsibility or liability associated with use of licensed/copyrighted material, including transmitting, reproducing, redistributing, or making commercial use of any third party data. The IBI group does not provide legal advice regarding copyright, fair use, or other aspects of intellectual property rights. Persons contemplating any type of transmission or reproduction of copyrighted material such as abstracts are advised to consult legal counsel.

  18. DisGeNET logo
  19. Creative Commons License
    DisGeNET Logo by IBI Group is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.