Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7840
Gene Symbol: ALMS1
ALMS1
CUI: C0028754
Disease: Obesity
Obesity 		0.370 Biomarker MGD Alms1-/- mice develop features similar to patients with AS, including obesity, hypogonadism, hyperinsulinemia, retinal dysfunction and late-onset hearing loss. 16000322

2005
Entrez Id: 83854
Gene Symbol: ANGPTL6
ANGPTL6
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker MGD This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance. 15778720

2005
Entrez Id: 22852
Gene Symbol: ANKRD26
ANKRD26
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker MGD A model for obesity and gigantism due to disruption of the Ankrd26 gene. 18162531

2008
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker MGD

Entrez Id: 434
Gene Symbol: ASIP
ASIP
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker MGD Mutations at the agouti locus in the mouse. 5798139

1969
Entrez Id: 434
Gene Symbol: ASIP
ASIP
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker MGD Disruption of the RIIbeta subunit of PKA reverses the obesity syndrome of Agouti lethal yellow mice. 18172198

2008
Entrez Id: 434
Gene Symbol: ASIP
ASIP
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker MGD Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. 17101998

2006
Entrez Id: 582
Gene Symbol: BBS1
BBS1
CUI: C0028754
Disease: Obesity
Obesity 		0.620 Biomarker MGD Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. 15322545

2004
Entrez Id: 585
Gene Symbol: BBS4
BBS4
CUI: C0028754
Disease: Obesity
Obesity 		0.660 Biomarker MGD Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse. 15322545

2004
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Carboxypeptidase E (CPE) deficiency in mice with the fat mutation have reduced stomach function. 9893169

1999
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. 2250094

1991
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 12270926

2002
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity. 7663508

1995
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Atherosclerosis in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. 8177043

1994
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. 9019408

1997
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Intracellular misrouting and abnormal secretion of adrenocorticotropin and growth hormone in cpefat mice associated with a carboxypeptidase E mutation. 9144234

1997
Entrez Id: 1363
Gene Symbol: CPE
CPE
CUI: C0028754
Disease: Obesity
Obesity 		0.730 Biomarker MGD Characterization of plasma lipids in genetically obese mice: the mutants obese, diabetes, fat, tubby, and lethal yellow. 8177042

1994
Entrez Id: 2835
Gene Symbol: GPR12
GPR12
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker MGD In conclusion, GPCR12 is considered important for the energy balance since GPCR12 KO mice develop obesity and have lower energy expenditure. 16887097

2006
Entrez Id: 2984
Gene Symbol: GUCY2C
GUCY2C
CUI: C0028754
Disease: Obesity
Obesity 		0.230 Biomarker MGD Moreover, the uroguanylin-GUCY2C endocrine axis may provide a therapeutic target to control appetite, obesity, and metabolic syndrome. 21865642

2011
Entrez Id: 55818
Gene Symbol: KDM3A
KDM3A
CUI: C0028754
Disease: Obesity
Obesity 		0.210 Biomarker MGD The loss of Jhdm2a function results in obesity and hyperlipidemia in mice. 19194461

2009
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Diminished epinephrine excretion in genetically obese (ob/ob) mice and monosodium glutamate-treated rats. 1382044

1992
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Increased pulmonary responses to acute ozone exposure in obese db/db mice. 16373670

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin is required for uncoupling protein-1-independent thermogenesis during cold stress. 16469807

2006
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD BBS-induced ciliary defect enhances adipogenesis, causing paradoxical higher-insulin sensitivity, glucose usage, and decreased inflammatory response. 22958920

2012
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity 		0.700 Biomarker MGD Leptin is a circulating hormone and major adiposity signal involved in long-term energy homeostasis. 16293682

2006