Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0016059
Disease: Fibrosis
Fibrosis
0.010 AlteredExpression LHGDN Oxidative stress induces extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase in cystic fibrosis lung epithelial cells: Potential mechanism for excessive IL-8 expression. 17936667

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0017919
Disease: Glycogen Storage Disease
Glycogen Storage Disease
0.010 Biomarker LHGDN Necrotic foci, elevated chemokines and infiltrating neutrophils in the liver of glycogen storage disease type Ia. 18191274

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0024291
Disease: Lymphohistiocytosis, Hemophagocytic
Lymphohistiocytosis, Hemophagocytic
0.010 Biomarker LHGDN Increased serum monocyte chemoattractant protein-1, macrophage inflammatory protein-1beta, and interleukin-8 concentrations in hemophagocytic lymphohistiocytosis. 18623207

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0037928
Disease: Spinal Cord Diseases
Spinal Cord Diseases
0.010 Biomarker LHGDN The expression of interleukin-8 (IL-8), IL-10, and tumor necrosis factor-alpha (TNF-alpha) were measured in the cerebrospinal fluid (CSF) of patients with cervical myelopathy. 18391721

2008

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0023055
Disease: Laryngeal neoplasm
Laryngeal neoplasm
0.010 GeneticVariation LHGDN Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. 17356794

2007

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0025007
Disease: Measles
Measles
0.010 Biomarker LHGDN BAL IL-8 levels correlated significantly with neutrophil percentages in both the measles BO group (r = 0.86, p = 0.000) and the control group (r = 0.79, p = 0.007). 17494793

2007

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0026640
Disease: Mouth Neoplasms
Mouth Neoplasms
0.010 GeneticVariation LHGDN The interleukin-8 (-251A/T) polymorphism is associated with increased risk for oral squamous cell carcinoma. 17174061

2007

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0004659
Disease: Bacteriuria
Bacteriuria
0.010 AlteredExpression LHGDN Interleukin (IL)-6 and IL-8 levels were measured in urine samples from patients with asymptomatic bacteriuria, symptomatic urinary tract infection and patients without bacteriuria (control group). 16794530

2006

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0015397
Disease: Disorder of eye
Disorder of eye
0.010 AlteredExpression LHGDN IL-8 and IFN-gamma in tear fluid of patients with cystic fibrosis. 16487026

2006

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0027121
Disease: Myositis
Myositis
0.010 Biomarker LHGDN Expression of toll-like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL-8 release and up-regulation of NKG2D-ligands. 16293707

2006

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0393571
Disease: Multiple System Atrophy
Multiple System Atrophy
0.010 GeneticVariation LHGDN Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-alpha gene polymorphisms and the risk for multiple system atrophy. 15607204

2005

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0008354
Disease: Cholera
Cholera
0.010 AlteredExpression LHGDN Interleukin 8 (IL-8) mRNA expression in Vibrio cholerae-infected human intestinal epithelial cells Int407 was determined by quantitative real-time RT-PCR and secretion measured by ELISA. 15158775

2004

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0032453
Disease: Polychondritis, Relapsing
Polychondritis, Relapsing
0.010 AlteredExpression LHGDN Serum cytokine profiles in relapsing polychondritis suggest monocyte/macrophage activation. 15529362

2004

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C1527298
Disease: Dysentery, Bacillary
Dysentery, Bacillary
0.010 Biomarker LHGDN Indeed, this work demonstrates that the delivery of recombinant human IL-8, together with Shigella infection of the colonic epithelial surface, causes an acute colitis characterized by a strong PMN infiltrate that, by all criteria, including transcription profiles of key mediators of the innate/inflammatory response and histopathological lesions, mimics bacillary dysentery. 15356171

2004

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0001576
Disease: Adnexal Diseases
Adnexal Diseases
0.010 AlteredExpression LHGDN Location and intensity of IL-8 and TGF-beta2 mRNA production in the fimbrial compartment of fallopian tubes and IL-10 in the endometrium in patients with pyoinflammatory adnexal diseases. 12802400

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0003130
Disease: Anoxia
Anoxia
0.010 Biomarker LHGDN Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1. 12391099

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0005940
Disease: Bone Diseases
Bone Diseases
0.010 Biomarker LHGDN Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. 12919697

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0006261
Disease: Bronchial Diseases
Bronchial Diseases
0.010 AlteredExpression LHGDN Abrogation of MRP-14 activity with a specific antibody also reduced the IL-8-stimulating potential of bronchial secretions, suggesting it was a significant stimulus to IL-8 production in the lung and may amplify the neutrophilic inflammation seen in bronchial disease. 12748056

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0007117
Disease: Basal cell carcinoma
Basal cell carcinoma
0.010 Biomarker LHGDN Mast cells in basal cell carcinoma express VEGF, IL-8 and RANTES. 12660426

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0036130
Disease: Salpingitis
Salpingitis
0.010 Biomarker LHGDN Expression and regulation of interleukin-8 in human fallopian tubal cells. 12634636

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0497327
Disease: Dementia
Dementia
0.010 AlteredExpression LHGDN Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia. 12548717

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
HIV-Associated Lipodystrophy Syndrome
0.010 AlteredExpression LHGDN AT mRNA of TNF-alpha, IL-6, and IL-8 was increased in AT of HALS subjects (P < 0.05), and both AT TNF-alpha mRNA and plasma TNF-alpha were negatively correlated to plasma adiponectin (P < 0.05). 12876073

2003

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0002940
Disease: Aneurysm
Aneurysm
0.010 AlteredExpression LHGDN More pronounced inflammatory changes and higher cytosol cytokine levels [IL6 (p<0.001), IL8 (p<0.0003) and TNFalpha (p<0.002)] were found in the walls of ruptured aneurysms than in the asymptomatic aneurysms. 12850808

2002

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome
0.010 AlteredExpression LHGDN Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome. 11888846

2002

Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
CUI: C0004238
Disease: Atrial Fibrillation
Atrial Fibrillation
0.020 AlteredExpression LHGDN Source of inflammatory markers in patients with atrial fibrillation. 18523031

2008