Gene Gene Full Name DSI g DPI g pLI Disease Type Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. Last Ref.
Entrez Id: 7157
Gene Symbol: TP53
TP53
tumor protein p53 0.236 0.962 0.53
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.330 None 0.800 5 0 1996 2011
Entrez Id: 3569
Gene Symbol: IL6
IL6
interleukin 6 0.248 0.962 0.32
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.030 None 1.000 3 0 2004 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
vascular endothelial growth factor A 0.266 0.923 2.4E-05
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.050 None 1.000 5 0 2002 2014
Entrez Id: 3586
Gene Symbol: IL10
IL10
interleukin 10 0.281 0.923 5.9E-03
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2013 2013
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
transforming growth factor beta 1 0.287 0.962 3.7E-02
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.320 None 1.000 2 0 2004 2005
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
interferon gamma 0.288 0.962 0.47
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2014 2014
Entrez Id: 596
Gene Symbol: BCL2
BCL2
BCL2 apoptosis regulator 0.291 0.885 0.56
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.030 None 0.667 3 0 2012 2017
Entrez Id: 1401
Gene Symbol: CRP
CRP
C-reactive protein 0.299 0.962 3.7E-03
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 0 2011 2017
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
catenin beta 1 0.303 0.885 1.00
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 0 2008 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
matrix metallopeptidase 9 0.305 0.923 1.9E-17
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 1 2015 2015
Entrez Id: 3576
Gene Symbol: CXCL8
CXCL8
C-X-C motif chemokine ligand 8 0.310 0.962 2.7E-04
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 0 2009 2014
Entrez Id: 207
Gene Symbol: AKT1
AKT1
AKT serine/threonine kinase 1 0.311 0.962 0.98
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2019 2019
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
insulin like growth factor 1 0.318 0.885 0.27
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2019 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
signal transducer and activator of transcription 3 0.320 0.923 1.00
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.030 None 1.000 3 0 2009 2013
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
toll like receptor 4 0.321 0.962 4.6E-09
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2017 2017
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
hypoxia inducible factor 1 subunit alpha 0.327 0.923 0.98
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2019 2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
angiotensin I converting enzyme 0.328 0.923 1.0E-37
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2015 2015
Entrez Id: 1437
Gene Symbol: CSF2
CSF2
colony stimulating factor 2 0.330 0.962 0.83
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 0 1991 2012
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
matrix metallopeptidase 2 0.333 0.923 0.84
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2015 2015
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
methylenetetrahydrofolate reductase 0.337 0.885 3.2E-10
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 2 2014 2014
Entrez Id: 4609
Gene Symbol: MYC
MYC
MYC proto-oncogene, bHLH transcription factor 0.344 0.923 1.00
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.020 None 1.000 2 0 1998 2008
Entrez Id: 595
Gene Symbol: CCND1
CCND1
cyclin D1 0.344 0.923 0.89
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2008 2008
Entrez Id: 627
Gene Symbol: BDNF
BDNF
brain derived neurotrophic factor 0.345 0.923 0.66
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2019 2019
Entrez Id: 367
Gene Symbol: AR
AR
androgen receptor 0.351 0.846 0.99
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.050 None 1.000 5 0 1995 2012
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
secreted phosphoprotein 1 0.353 0.885 2.1E-06
CUI: C0040028
Disease: Thrombocythemia, Essential
Thrombocythemia, Essential
disease 0.010 None 1.000 1 0 2018 2018