Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7791
Gene Symbol: ZYX
ZYX
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma
0.020 AlteredExpression LHGDN We observe similar phenotypic changes after zyxin gene transfer in SK-N-MC cells, suggesting that zyxin has tumor suppressor activity in Ewing tumor cells. 15748890

2005

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 Biomarker LHGDN DARPP-32 mediates multidrug resistance of gastric cancer through regulation of P-gp and ZNRD1. 18058465

2007

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 Biomarker LHGDN Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells. 17389617

2007

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 AlteredExpression LHGDN Overexpression of ZNRD1 promotes multidrug-resistant phenotype of gastric cancer cells through upregulation of P-glycoprotein. 14726695

2004

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 AlteredExpression LHGDN Reversal of multidrug resistance of adriamycin-resistant gastric adenocarcinoma cells through the up-regulation of DARPP-32. 17492506

2008

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 Biomarker LHGDN Suppression of the cell proliferation in stomach cancer cells by the ZNRD1 gene. 15358150

2004

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.360 Biomarker LHGDN ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. 15662122

2005

Entrez Id: 30834
Gene Symbol: ZNRD1
ZNRD1
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms
0.030 AlteredExpression LHGDN ZNRD1 expression was also confirmed to be down-regulated in esophageal cancer tissues compared to adjacent non-neoplastic tissues. 18594968

2009

Entrez Id: 9326
Gene Symbol: ZNHIT3
ZNHIT3
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.010 AlteredExpression LHGDN [Relationship between expression of GYPC and TRIP3 genes and prognosis of acute lymphoblastic leukemia in children]. 19149918

2009

Entrez Id: 57169
Gene Symbol: ZNFX1
ZNFX1
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.010 Biomarker LHGDN Antigen-specific IgG elicited in subjects with prostate cancer treated with flt3 ligand. 15838384

2005

Entrez Id: 79755
Gene Symbol: ZNF750
ZNF750
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.030 GeneticVariation LHGDN This report suggests that ZNF750 mutations could contribute to psoriasis susceptibility. 18256691

2008

Entrez Id: 641339
Gene Symbol: ZNF674
ZNF674
CUI: C1136249
Disease: Mental Retardation, X-Linked
Mental Retardation, X-Linked
0.510 Biomarker LHGDN We characterized the complete ZNF674 gene structure and subsequently tested an additional 306 patients with XLMR for mutations by direct sequencing. 16385466

2006

Entrez Id: 26036
Gene Symbol: ZNF451
ZNF451
CUI: C0023418
Disease: leukemia
leukemia
0.010 AlteredExpression LHGDN ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. 18656483

2008

Entrez Id: 10224
Gene Symbol: ZNF443
ZNF443
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.010 AlteredExpression LHGDN Paeoniae Radix, a Chinese herbal extract, inhibit hepatoma cells growth by inducing apoptosis in a p53 independent pathway. 12215374

2002

Entrez Id: 55893
Gene Symbol: ZNF395
ZNF395
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
0.070 Biomarker LHGDN Next, to identify the apoptosis regulator of PBF, we screened a cDNA library constructed from mRNA of the osteosarcoma cell line OS2000 using a yeast two-hybrid system and isolated Scythe/BAT3. 19018758

2009

Entrez Id: 25946
Gene Symbol: ZNF385A
ZNF385A
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases
0.010 AlteredExpression LHGDN Taken together, these observations suggest that RZF is a shuttling regulatory protein expressed in photoreceptors of the human retina that may be involved in mRNA or protein regulation of photoreceptor-specific genes and therefore have role in retinal disease mechanisms. 15527981

2004

Entrez Id: 171017
Gene Symbol: ZNF384
ZNF384
CUI: C0023418
Disease: leukemia
leukemia
0.050 AlteredExpression LHGDN We show that, as result of a t(12;17)(p13;q11) or its variant t(12;22)(p13;q12), the transcription factor gene CIZ/NMP4 is recurrently involved in acute leukemia through fusion with either EWSR1 or TAF15. 12359745

2002

Entrez Id: 171017
Gene Symbol: ZNF384
ZNF384
CUI: C0023418
Disease: leukemia
leukemia
0.050 Biomarker LHGDN CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients. 15990865

2005

Entrez Id: 59348
Gene Symbol: ZNF350
ZNF350
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 GeneticVariation LHGDN Direct sequencing of ZBRK1 entire coding region in affected breast cancer individuals from 97 high-risk French Canadian breast/ovarian cancer families and 94 healthy controls led to the identification of 18 genomic variants. 17764113

2008

Entrez Id: 59348
Gene Symbol: ZNF350
ZNF350
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.020 GeneticVariation LHGDN Based on sequencing of ZBRK1 and BRIP1 in 21 BRCA1/2-negative probands from inherited breast/ovarian cancer families, it appears unlikely that mutations in these genes account for a significant fraction of inherited breast cancer. 12872252

2003

Entrez Id: 55422
Gene Symbol: ZNF331
ZNF331
CUI: C0040136
Disease: Thyroid Neoplasm
Thyroid Neoplasm
0.020 AlteredExpression LHGDN A 3.4-kbp transcript of ZNF331 is solely expressed in follicular thyroid adenomas. 14610350

2003

Entrez Id: 10795
Gene Symbol: ZNF268
ZNF268
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.010 Biomarker LHGDN Our study thus suggests that aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies. 18949428

2008

Entrez Id: 10308
Gene Symbol: ZNF267
ZNF267
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis
0.030 AlteredExpression LHGDN Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y. 15814297

2005

Entrez Id: 7764
Gene Symbol: ZNF217
ZNF217
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.060 Biomarker LHGDN Detection of Her2/neu, c-MYC and ZNF217 gene amplification during breast cancer progression using fluorescence in situ hybridization. 15756435

2005

Entrez Id: 7764
Gene Symbol: ZNF217
ZNF217
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.060 Biomarker LHGDN Genome analysis identifies the p15ink4b tumor suppressor as a direct target of the ZNF217/CoREST complex. 18625718

2008