Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.200 Therapeutic RGD Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic-ischemic encephalopathy. 23694759

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 SusceptibilityMutation RGD Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. 24275070

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0011263
Disease: Multi-infarct dementia
Multi-infarct dementia 		0.200 Biomarker RGD Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia. 22342912

2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0024636
Disease: Malocclusion
Malocclusion 		0.200 ModifyingMutation RGD This study was designed to investigate the expression differences of insulin-like growth factor-1 (IGF1), IGF type 1 receptor (IGFR1) and IGF-binding protein-3 (IGFBP3) in mandibular condylar cartilage between male and female rats with experimentally created malocclusion. 22758598

2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0085677
Disease: Alcoholic Neuropathy
Alcoholic Neuropathy 		0.200 Biomarker RGD Experimental alcohol-related peripheral neuropathy: role of insulin/IGF resistance. 23016131

2012
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0021818
Disease: Intervertebral Disk Displacement
Intervertebral Disk Displacement 		0.200 Biomarker RGD Localization and function of insulin-like growth factor 1 in dorsal root ganglia in a rat disc herniation model. 21037532

2011
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0235950
Disease: Zinc deficiency
Zinc deficiency 		0.200 Biomarker RGD The influence of gestational zinc deficiency on the fetal insulin-like growth factor axis in the rat. 20404036

2010
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.200 Biomarker RGD Changes in the expression of insulin-like growth factor 1 variants in the postnatal brain development and in neonatal hypoxia-ischaemia. 19766709

2010
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0154088
Disease: Carcinoma in situ of prostate
Carcinoma in situ of prostate 		0.200 Biomarker RGD Characterization of SV-40 Tag rats as a model to study prostate cancer. 19171036

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0020505
Disease: Hyperphagia
Hyperphagia 		0.200 Biomarker RGD Central insulin-like growth factor 1 receptors play distinct roles in the control of reproduction, food intake, and body weight in female rats. 17567960

2007
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0151482
Disease: Megaloblastic anemia due to folate deficiency
Megaloblastic anemia due to folate deficiency 		0.200 Biomarker RGD Decreased TGF-beta1 and IGF-1 protein expression in rat embryo skull bone in folic acid-restricted diet. 16111879

2006
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C2985290
Disease: Fetal Alcohol Spectrum Disorders
Fetal Alcohol Spectrum Disorders 		0.200 Biomarker RGD Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. 16909201

2006
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0242231
Disease: Coronary Stenosis
Coronary Stenosis 		0.200 Biomarker RGD Impairment of myocyte contractility following coronary artery narrowing is associated with activation of the myocyte IGF1 autocrine system, enhanced expression of late growth related genes, DNA synthesis, and myocyte nuclear mitotic division in rats. 8102103

1993
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0010308
Disease: Congenital Hypothyroidism
Congenital Hypothyroidism 		0.200 Biomarker RGD The effects of thyroid hormone on insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) expression in the neonatal rat: prolonged high expression of IGFBP-2 in methimazole-induced congenital hypothyroidism. 1718729

1991
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0342200
Disease: Endemic Cretinism
Endemic Cretinism 		0.200 Biomarker RGD The effects of thyroid hormone on insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) expression in the neonatal rat: prolonged high expression of IGFBP-2 in methimazole-induced congenital hypothyroidism. 1718729

1991
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.210 ModifyingMutation RGD Endothelin-1-induced focal cerebral ischemia in the growth hormone/IGF-1 deficient Lewis Dwarf rat. 25098324

2014
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies 		0.210 Biomarker RGD Independent alterations in the central and peripheral somatosensory pathways in rat diabetic neuropathy. 19264110

2009
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0521170
Disease: Osteoporotic Fractures
Osteoporotic Fractures 		0.210 Therapeutic RGD Effects of recombinant human growth hormone (r-hGH) on experimental osteoporotic fracture healing. 11834155

2001
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0162770
Disease: Right Ventricular Hypertrophy
Right Ventricular Hypertrophy 		0.210 Therapeutic RGD RV hypertrophy was associated with activation of IGF-I independent of the renin-angiotensin system. 10090325

1999
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.220 Biomarker RGD Cyclooxygenase-2 [corrected] activation by endotoxin mediates the decrease in IGF1, but not in IGFBP3, [corrected] gene expression in the liver. 18492809

2008
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0409959
Disease: Osteoarthritis, Knee
Osteoarthritis, Knee 		0.220 ModifyingMutation RGD Effects of chronic growth hormone and insulin-like growth factor 1 deficiency on osteoarthritis severity in rat knee joints. 17133593

2006
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.220 Biomarker RGD Regulation of the acid-labile subunit in sustained endotoxemia. 12217886

2002
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0011269
Disease: Dementia, Vascular
Dementia, Vascular 		0.230 Biomarker RGD Down-regulation of IGF-1/IGF-1R in hippocampus of rats with vascular dementia. 22342912

2012