×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.
2105486 1990
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
2674130 1989
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
Ras p21 proteins with high or low GTPase activity can efficiently transform NIH/3T3 cells.
3004741 1986
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
The ras gene family and human carcinogenesis.
3283542 1988
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
ras genes.
3304147 1987
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus.
6287572 1982
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
Nucleotide sequence of the oncogene encoding the p21 transforming protein of Kirsten murine sarcoma virus.
6287573 1982
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
Characterization of the phosphorylation sites and the surrounding amino acid sequences of the p21 transforming proteins coded for by the Harvey and Kirsten strains of murine sarcoma viruses.
6288698 1982
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
Role of the switch II region in the conformational transition of activation of Ha-ras-p21.
10716188 2000
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Germline mutations in HRAS proto-oncogene cause Costello syndrome .
16170316 2005
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Five different HRAS mutations have now been reported in Costello syndrome , however genotype-phenotype correlation remains incomplete.
16329078 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
HRAS mutations in Costello syndrome: detection of constitutional activating mutations in codon 12 and 13 and loss of wild-type allele in malignancy.
16372351 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
These results confirm that CS is caused, in most cases, by heterozygous missense mutations in the proto-oncogene HRAS .
16443854 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
These results confirm that CS is caused, in most cases, by heterozygous missense mutations in the proto-oncogene HRAS .
16443854 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Germline KRAS mutations cause Noonan syndrome.
16474405 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Paternal bias in parental origin of HRAS mutations in Costello syndrome.
16835863 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Recurring HRAS mutation G12S in Dutch patients with Costello syndrome.
16881968 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
Germline mutations in components of the Ras signaling pathway in Noonan syndrome and related disorders.
16921267 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
We report here on a female with findings suggestive of CS in whom mutation analysis performed with standard techniques on white blood cell derived DNA did not show an HRAS mutation.
16969868 2006
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
A de novo heterozygous HRAS change was detected in all the subjects diagnosed with CS , while no lesion was observed with any of the other phenotypes.
17054105 2007
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
A de novo heterozygous HRAS change was detected in all the subjects diagnosed with CS , while no lesion was observed with any of the other phenotypes.
17054105 2007
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
An unexpected new role of mutant Ras: perturbation of human embryonic development.
17211612 2007
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
GeneticVariation
CLINVAR
However, some patients carrying HRAS mutations may exhibit prominent congenital muscular dysfunction, although features of CS may be less obvious, suggesting that germline HRAS mutations may underlie some cases of otherwise unclassified neonatal neuromuscular disorders.
17412879 2007
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
However, some patients carrying HRAS mutations may exhibit prominent congenital muscular dysfunction, although features of CS may be less obvious, suggesting that germline HRAS mutations may underlie some cases of otherwise unclassified neonatal neuromuscular disorders.
17412879 2007
×
Entrez Id: 3265
Gene Symbol: HRAS
HRAS
Costello syndrome (disorder)
1.000
CausalMutation
CLINVAR
We report a patient with typical Costello syndrome and a novel heterozygous missense mutation in codon 117 (c.350A>G, p.Lys117Arg) of the HRAS gene, resulting in constitutive activation of the RAS/MAPK pathway similar to the typical p.Gly12Ser and p.Gly12Ala mutations.
17979197 2008