TRAF3IP2
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
In conclusion, T cells are necessary for the development of SLE -like disease in B6.Act1 (-/-) mice, but not BAFF-driven transitional B-cell differentiation.
22585710 2012
TNFRSF13B
Lupus Erythematosus, Systemic
0.280
Biomarker
MGD
Activation and accumulation of B cells in TACI-deficient mice.
11429549 2001
TNFRSF13B
Lupus Erythematosus, Systemic
0.280
Biomarker
MGD
Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor.
12594954 2003
×
Entrez Id: 51284
Gene Symbol: TLR7
TLR7
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
×
Entrez Id: 91937
Gene Symbol: TIMD4
TIMD4
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
27096368 2016
×
Entrez Id: 6256
Gene Symbol: RXRA
RXRA
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
×
Entrez Id: 9711
Gene Symbol: RUBCN
RUBCN
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells.
27096368 2016
×
Entrez Id: 6738
Gene Symbol: RO60
RO60
Lupus Erythematosus, Systemic
0.300
Biomarker
MGD
A lupus -like syndrome develops in mice lacking the Ro 60 -kDa protein, a major lupus autoantigen.
12788971 2003
×
Entrez Id: 149041
Gene Symbol: RC3H1
RC3H1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
15917799 2005
×
Entrez Id: 83593
Gene Symbol: RASSF5
RASSF5
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
RAPL -deficient mice experienced age-related lupus -like glomerulonephritis and developed B cell lymphomas.21194982 2011
×
Entrez Id: 10125
Gene Symbol: RASGRP1
RASGRP1
Lupus Erythematosus, Systemic
0.620
Biomarker
MGD
Autoimmunity as the consequence of a spontaneous mutation in Rasgrp1.
12932358 2003
×
Entrez Id: 5788
Gene Symbol: PTPRC
PTPRC
Lupus Erythematosus, Systemic
0.240
Biomarker
MGD
An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity.
11163182 2000
×
Entrez Id: 639
Gene Symbol: PRDM1
PRDM1
Lupus Erythematosus, Systemic
0.550
Biomarker
MGD
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
Lupus Erythematosus, Systemic
0.230
Biomarker
MGD
×
Entrez Id: 5423
Gene Symbol: POLB
POLB
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
We show that mice expressing this hypomorphic POLB allele develop an autoimmune pathology that strongly resembles SLE .
24388753 2014
×
Entrez Id: 5423
Gene Symbol: POLB
POLB
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.
22493258 2012
×
Entrez Id: 122618
Gene Symbol: PLD4
PLD4
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Pld4 mutant mice revealed autoimmune phenotypes suggesting functional involvement of PLD4 with the basics of SLE .30679154 2019
×
Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
Lupus Erythematosus, Systemic
0.800
Biomarker
MGD
Development of lupus -like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
10485649 1999
×
Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
Lupus Erythematosus, Systemic
0.800
Biomarker
MGD
Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts.
16237069 2005
×
Entrez Id: 5133
Gene Symbol: PDCD1
PDCD1
Lupus Erythematosus, Systemic
0.800
Biomarker
MGD
Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses.
9796923 1998
×
Entrez Id: 9219
Gene Symbol: MTA2
MTA2
Lupus Erythematosus, Systemic
0.200
Biomarker
MGD
Inactivation of NuRD component Mta2 causes abnormal T cell activation and lupus -like autoimmune disease in mice.
18353770 2008
×
Entrez Id: 4124
Gene Symbol: MAN2A1
MAN2A1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
We show that mutation of a single gene, encoding alpha-mannosidase II , which regulates the hybrid to complex branching pattern of extracellular asparagine (N)-linked oligosaccharide chains (N-glycans), results in a systemic autoimmune disease similar to human systemic lupus erythematosus . alpha-Mannosidase II -deficient autoimmune disease is due to an incomplete overlap of two conjoined pathways in complex-type N-glycan production.
11158608 2001
×
Entrez Id: 4124
Gene Symbol: MAN2A1
MAN2A1
Lupus Erythematosus, Systemic
0.210
Biomarker
MGD
Alpha-mannosidase-II deficiency results in dyserythropoiesis and unveils an alternate pathway in oligosaccharide biosynthesis.
9230311 1997
×
Entrez Id: 4067
Gene Symbol: LYN
LYN
Lupus Erythematosus, Systemic
0.320
Biomarker
MGD
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
20512127 2010
×
Entrez Id: 4067
Gene Symbol: LYN
LYN
Lupus Erythematosus, Systemic
0.320
Biomarker
MGD
Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.
11672542 2001