×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
We conclude that the APP locus may predispose to AD in the very elderly.
11500807 2001
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease.
11831556 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
The signal on 20p is near the location of the gene coding for cystatin-C, previously shown to be associated with late-onset AD and to codeposit with APP in the brains of patients with AD .
12016588 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Moreover, in the same pool of AD patients, alpha APP s levels were reduced concomitantly in CSF.
12080182 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer's disease.
12177374 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Human cerebrospinal fluid apolipoprotein E isoforms are apparently inefficient at complexing with synthetic Alzheimer's amyloid-[beta] peptide (A[beta] 1-40 ) in vitro.
12393935 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
AlteredExpression
LHGDN
Thus, our data indicated that variation of APP gene expression in PMBC might be a pathogenic source of Alzheimer's disease .
12627474 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis.
12702875 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Amyloid precursor protein (APP ) and the biology of proteolytic processing: relevance to Alzheimer's disease .12824062 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
Although APP mutations associated with inherited forms of Alzheimer's disease (AD ) are relatively rare, detailed studies of these mutations may prove critical for gaining important insights into the mechanism(s) and etiology of AD .
12972252 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
A beta 1-42 induces production of quinolinic acid by human macrophages and microglia.
14663182 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
15087549 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
In particular, it is well known that oxidation of methionine 35, is strongly related to the pathogenesis of Alzheimer's disease , since it represents the residue in the beta-amyloid peptide most susceptible to oxidation "in vivo".
15203119 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
AlteredExpression
LHGDN
Frame-shifted amyloid precursor protein found in Alzheimer's disease and Down's syndrome increases levels of secreted amyloid beta40.
15255950 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
AlteredExpression
LHGDN
Spatial learning and exploration of environmental stimuli in 24-month-old female APP23 transgenic mice with the Swedish mutation.
15451372 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
AlteredExpression
LHGDN
Amyloid-beta (Abeta) the primary component of the senile plaques found in Alzheimer's disease (AD ) is generated by the rate-limiting cleavage of amyloid precursor protein (APP ) by beta-secretase followed by gamma-secretase cleavage.
15452128 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
Understanding the molecular mechanism of beta-amyloid (Abeta ) generation is crucial for Alzheimer's disease pathogenesis as well as for normal APP function.
15474359 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Familial Alzheimer disease associated with A713T mutation in APP.
15488330 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.
15509549 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Herein we investigated the processing of beta-secretase (BACE), implicated in Alzheimer's disease through processing of beta-amyloid precursor protein (betaAPP ), into smaller metabolites.
15522224 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Synaptic targeting by Alzheimer's-related amyloid beta oligomers.
15537891 2004
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
The occurrence of an APP T174I mutation is described in a large American family of African descent with Alzheimer disease .
15668448 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
Biomarker
LHGDN
Accumulation of Abeta protein in beta-amyloid deposits is a hallmark event in Alzheimer's disease (AD ).
15728175 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
Novel mutations and repeated findings of mutations in familial Alzheimer disease.
15776278 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Alzheimer's Disease
0.900
GeneticVariation
LHGDN
TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels.
15895461 2005