Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental
0.500 Biomarker RGD [Modulative effect of zhenqing recipe on expressions of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in experimental type 2 diabetic rats]. 17569353

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.300 Therapeutic RGD Rat coronary atherosclerosis heart disease model can be successfully established by feeding with high-fat diet and intraperitoneal injection of VD3, the permeability of coronary artery in coronary heart disease rat model is significantly increased, which may be related to up-regulation of MMP-9, CD40L, TNF-α and CRP expression. 26261622

2015

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease
0.300 Therapeutic RGD Rat coronary atherosclerosis heart disease model can be successfully established by feeding with high-fat diet and intraperitoneal injection of VD3, the permeability of coronary artery in coronary heart disease rat model is significantly increased, which may be related to up-regulation of MMP-9, CD40L, TNF-α and CRP expression. 26261622

2015

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 Therapeutic RGD To investigate the effect of periodontal mechanical treatment on serum interleukin-6 (IL-6) and carotid artery matrix metalloproteinase (MMP)-2 and MMP-9 expression in chronic periodontitis (CP) SD rats with atherosclerosis (As). 24820783

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.300 Therapeutic RGD Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. 23149858

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy
0.300 Therapeutic RGD Lumbrokinase attenuates diabetic nephropathy through regulating extracellular matrix degradation in Streptozotocin-induced diabetic rats. 23384615

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
Diabetes Mellitus, Non-Insulin-Dependent
0.300 Therapeutic RGD Decrease in serum matrix metalloproteinase-9 and matrix metalloproteinase-3 levels in Zucker fa/fa obese rats after treatment with swertiamarin. 23204894

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.300 Biomarker RGD Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases. 20085636

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma
0.300 Biomarker RGD Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. 20434464

2010

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.300 Biomarker RGD Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. 19556529

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker RGD Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. 17913382

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.300 Biomarker RGD Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. 17913382

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases
0.300 Biomarker RGD Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats. 17392157

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage
0.300 Biomarker RGD Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage. 17410600

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.300 Biomarker RGD Our results suggest that the expression of CD40 and CD40L in the blood cells and the activities of MMP-2 and MMP-9 in plasma were higher in As group than those in Normal group, indicating that they may contribute to the formation of atherosclerosis. 16317521

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.300 Biomarker RGD Here, we used a combination of pharmacological and genetic approaches to show that tPA promotes MMP-9 levels in stroke in vivo. 16051896

2005

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018801
Disease: Heart failure
Heart failure
0.300 Biomarker RGD Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. 11342481

2001

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.300 Biomarker RGD Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. 11342481

2001

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.290 Biomarker RGD Matrix metalloprotease expressions in both reperfusion lung injury and oleic acid lung injury models and the protective effects of ilomastat. 19545667

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.290 Biomarker RGD Inhibition of matrix metalloproteinase-9 with doxycycline reduces pancreatitis-associated lung injury. 19494493

2009

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.280 Biomarker RGD Our present study was designed to clarify the relation among hyperglycemia, oxidative stress, and MMP-9 activation associated with BBB dysfunction after transient focal cerebral ischemia (tFCI). 17272778

2007

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.270 Biomarker RGD T1DM increases IA formation.The increased RAGE, MMP9 and TLR4 expressions might contribute to IA formation in T1DM rats. 23844137

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis
0.270 Biomarker RGD [Effects of xinfeng capsule on myocardial fibrosis in adjuvant arthritis rats and its mechanism research]. 23905389

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.270 Therapeutic RGD Imidapril inhibits cerebral aneurysm formation in an angiotensin-converting enzyme-independent and matrix metalloproteinase-9-dependent manner. 21937941

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm
0.270 Biomarker RGD Macrophage-derived matrix metalloproteinase-2 and -9 promote the progression of cerebral aneurysms in rats. 17122420

2007