Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 55835
Gene Symbol: CENPJ
CENPJ
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD K-RasV14I recapitulates Noonan syndrome in mice. 25359213

2014
Entrez Id: 80254
Gene Symbol: CEP63
CEP63
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD

Entrez Id: 5781
Gene Symbol: PTPN11
PTPN11
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation. 15273746

2004
Entrez Id: 545
Gene Symbol: ATR
ATR
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD

Entrez Id: 5894
Gene Symbol: RAF1
RAF1
CUI: C0175701
Disease: Aarskog syndrome
Aarskog syndrome 		0.200 Biomarker MGD Increased BRAF heterodimerization is the common pathogenic mechanism for noonan syndrome-associated RAF1 mutants. 22826437

2012
Entrez Id: 23410
Gene Symbol: SIRT3
SIRT3
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 5584
Gene Symbol: PRKCI
PRKCI
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 2984
Gene Symbol: GUCY2C
GUCY2C
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 1489
Gene Symbol: CTF1
CTF1
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 10891
Gene Symbol: PPARGC1A
PPARGC1A
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker RGD Modified high-sucrose diet-induced abdominally obese and normal-weight rats developed high plasma free fatty acid and insulin resistance. 23320128

2012
Entrez Id: 79661
Gene Symbol: NEIL1
NEIL1
CUI: C2930930
Disease: Abdominal obesity metabolic syndrome
Abdominal obesity metabolic syndrome 		0.200 Biomarker MGD

Entrez Id: 8989
Gene Symbol: TRPA1
TRPA1
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain 		0.200 Biomarker RGD Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. 24291101

2014
Entrez Id: 2353
Gene Symbol: FOS
FOS
CUI: C1879526
Disease: Aberrant Crypt Foci
Aberrant Crypt Foci 		0.200 Biomarker RGD Colonic aberrant crypt foci are associated with increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic lesions in colon cancer. 1576709

1992
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1879526
Disease: Aberrant Crypt Foci
Aberrant Crypt Foci 		0.200 Therapeutic RGD Yerba mate tea and mate saponins prevented azoxymethane-induced inflammation of rat colon through suppression of NF-κB p65ser(311) signaling via IκB-α and GSK-3β reduced phosphorylation. 23554136

2014
Entrez Id: 2353
Gene Symbol: FOS
FOS
CUI: C1879526
Disease: Aberrant Crypt Foci
Aberrant Crypt Foci 		0.200 Therapeutic RGD The most important findings of this investigation are that intervention with all-trans retinoic acid in the pre-malignant stage of colon carcinogenesis is effective in decreasing the number and growth of aberrant crypt foci and altering the expression of the c-myc and c-fos genes. 8449605

1993
Entrez Id: 7042
Gene Symbol: TGFB2
TGFB2
CUI: C1879526
Disease: Aberrant Crypt Foci
Aberrant Crypt Foci 		0.200 Therapeutic RGD Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats. 17293967

2006
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C1879526
Disease: Aberrant Crypt Foci
Aberrant Crypt Foci 		0.200 Therapeutic RGD Effects of all-trans retinoic acid as a potential chemopreventive agent on the formation of azoxymethane-induced aberrant crypt foci: differential expression of c-myc and c-fos MRNA and protein. 8449605

1993
Entrez Id: 57152
Gene Symbol: SLURP1
SLURP1
CUI: C0432333
Disease: Abnormal dermatoglyphic pattern
Abnormal dermatoglyphic pattern 		0.200 Biomarker MGD Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. 24499735

2014
Entrez Id: 57152
Gene Symbol: SLURP1
SLURP1
CUI: C0221199
Disease: Abnormal palmar creases
Abnormal palmar creases 		0.200 Biomarker MGD Palmoplantar keratoderma along with neuromuscular and metabolic phenotypes in Slurp1-deficient mice. 24499735

2014
Entrez Id: 866
Gene Symbol: SERPINA6
SERPINA6
CUI: C0271749
Disease: Abnormality of cortisol-binding globulin
Abnormality of cortisol-binding globulin 		0.200 Biomarker MGD Plasma transcortin influences endocrine and behavioral stress responses in mice. 20022933

2010
Entrez Id: 866
Gene Symbol: SERPINA6
SERPINA6
CUI: C0271749
Disease: Abnormality of cortisol-binding globulin
Abnormality of cortisol-binding globulin 		0.200 Biomarker MGD Hyporesponsiveness to glucocorticoids in mice genetically deficient for the corticosteroid binding globulin. 16980625

2006
Entrez Id: 773
Gene Symbol: CACNA1A
CACNA1A
CUI: C0014553
Disease: Absence Epilepsy
Absence Epilepsy 		0.760 Biomarker RGD Thus, the GRY rat with P/Q-type Ca(2+) channel disorders is a useful model for studying absence epilepsy and Cacna1a-related diseases. 17196942

2007