Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.500 Therapeutic RGD Anticonvulsant activity of Benkara malabarica (Linn.) root extract: In vitro and in vivo investigation. 20109543

2010
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.500 Biomarker RGD Identification of a median thalamic system regulating seizures and arousal. 2753001

1989
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.500 Biomarker RGD Glutamate decarboxylase and GABA aminotransferase levels in different regions of rat brain on the onset of Leptazol induced convulsions. 21935729

2012
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0037769
Disease: West Syndrome
West Syndrome 		0.210 Therapeutic RGD Infantile spasms (IS) have poor outcomes and limited treatment options, including vigabatrin, a γ-aminobutyric acid (GABA) aminotransferase inactivator. 24321005

2014
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0003123
Disease: Anorexia
Anorexia 		0.200 Biomarker RGD Anorectic potency of inhibiting GABA transaminase in brain: studies of hypothalamic, dietary and genetic obesities. 6534893

1984
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.200 Biomarker RGD Enhanced GABAergic tone in the ventral pallidum: memory of unpleasant experiences? 21914462

2011
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Alteration of the GABAergic neuronal system of the retina and superior colliculus in streptozotocin-induced diabetic rat. 9846053

1998
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced 		0.200 Biomarker RGD An analysis of the cortical and striatal involvement in dyskinesia induced in rats by intracerebral injection of GABA-transaminase inhibitors and picrotoxin. 6445277

1980
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0013386
Disease: Dyskinesia, Drug-Induced
Dyskinesia, Drug-Induced 		0.200 Biomarker RGD Suppression of haloperidol-induced oral dyskinesias in rats by vigabatrin. 7740056

1995
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0019337
Disease: Heroin Dependence
Heroin Dependence 		0.200 Biomarker RGD Increased mesolimbic GABA concentration blocks heroin self-administration in the rat. 10900239

2000
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0020179
Disease: Huntington Disease
Huntington Disease 		0.200 Therapeutic RGD Inhibitors of GABA metabolism: implications for Huntington's disease. 152600

1977
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.200 Therapeutic RGD Mechanism of GABA involvement in post-traumatic trigeminal neuropathic pain: activation of neuronal circuitry composed of PKCγ interneurons and pERK1/2 expressing neurons. 24890317

2015
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Biomarker RGD Effects of gamma-vinyl GABA (vigabatrin) on blood pressure and body weight of hypertensive and normotensive rats. 1570022

1992
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0022116
Disease: Ischemia
Ischemia 		0.200 Biomarker RGD Changes of GABA metabolic enzymes in acute retinal ischemia. 10375453

1999
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.200 Biomarker RGD Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats. 9344635

1997
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0040264
Disease: Tinnitus
Tinnitus 		0.200 Therapeutic RGD Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model. 17221143

2007
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0236736
Disease: Cocaine-Related Disorders
Cocaine-Related Disorders 		0.200 Therapeutic RGD (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction. 22128851

2012
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0242422
Disease: Parkinsonian Disorders
Parkinsonian Disorders 		0.200 Therapeutic RGD Assessment of the treatment effect of baicalein on a model of Parkinsonian tremor and elucidation of the mechanism. 22634324

2012
Entrez Id: 18
Gene Symbol: ABAT
ABAT
CUI: C0270857
Disease: Epilepsy, Reflex
Epilepsy, Reflex 		0.200 Biomarker RGD Behavioral effects of vigabatrin correlated with whole brain gamma-aminobutyric acid metabolism in audiogenic sensitive rats. 9706369

1998
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD ATP-binding cassette transporter A1 (ABCA1) affects total body sterol metabolism. 11266384

2001
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD ABCA1 defects cause Tangier disease, a disorder characterized by absence of high density lipoprotein and thrombocytopenia. 15163665

2004
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD Patients with Tangier disease exhibit extremely low plasma HDL concentrations resulting from mutations in the ATP-binding cassette, sub-family A, member 1 (ABCA1) protein. 15841208

2005
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD Taken together, these findings demonstrate that Abc1-/- mice display pathophysiologic hallmarks similar to human Tangier disease and highlight the capacity of ABC1 transporters to participate in the regulation of dietary cholesterol absorption. 10760292

2000
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD Similar to TD in humans, HDL-C is virtually absent in ABCA1-/- mice accompanied by a reduction in serum cholesterol and lipid deposition in various tissues. 10980140

2000
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
CUI: C0039292
Disease: Tangier Disease
Tangier Disease 		1.000 Biomarker MGD ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. 10878804

2000