Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5054
Gene Symbol: SERPINE1
SERPINE1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Therapeutic RGD An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure. 26903149

2016

Entrez Id: 632
Gene Symbol: BGLAP
BGLAP
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Role of dietary phosphorus and degree of uremia in the development of renal bone disease in rats. 17365904

2007

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.210 Biomarker RGD Left ventricular gene expressions of aldosterone synthase, mineralocorticoid receptor, and hydroxysteroid dehydrogenase type 2 were the same in the 3 groups, whereas gene expression of the glucocorticoid receptor was significantly diminished in chronic renal failure rats. 18591458

2008

Entrez Id: 1644
Gene Symbol: DDC
DDC
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery. 19167406

2009

Entrez Id: 3667
Gene Symbol: IRS1
IRS1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Vascular insulin resistance related to endoplasmic reticulum stress in aortas from a rat model of chronic kidney disease. 22942179

2012

Entrez Id: 6569
Gene Symbol: SLC34A1
SLC34A1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Regulation of NaPi-IIa mRNA and transporter protein in chronic renal failure: role of parathyroid hormone (PTH) and dietary phosphate (Pi). 15452708

2004

Entrez Id: 847
Gene Symbol: CAT
CAT
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. 20007347

2010

Entrez Id: 2057
Gene Symbol: EPOR
EPOR
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease. 27468524

2016

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy. 12110012

2002

Entrez Id: 4023
Gene Symbol: LPL
LPL
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression. 22009636

2012

Entrez Id: 23175
Gene Symbol: LPIN1
LPIN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. 14718385

2004

Entrez Id: 664
Gene Symbol: BNIP3
BNIP3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 38
Gene Symbol: ACAT1
ACAT1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. 19878707

2010

Entrez Id: 1244
Gene Symbol: ABCC2
ABCC2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007

Entrez Id: 1812
Gene Symbol: DRD1
DRD1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Therapeutic RGD Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats. 18402547

2008

Entrez Id: 50604
Gene Symbol: IL20
IL20
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Interleukin-20 targets renal cells and is associated with chronic kidney disease. 18639518

2008

Entrez Id: 384
Gene Symbol: ARG2
ARG2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. 16809898

2006

Entrez Id: 8435
Gene Symbol: SOAT2
SOAT2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Upregulation of acyl-CoA: cholesterol acyltransferase in chronic renal failure. 12217884

2002

Entrez Id: 8714
Gene Symbol: ABCC3
ABCC3
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of intestinal drug transporters in chronic renal failure in rats. 17135344

2007

Entrez Id: 6582
Gene Symbol: SLC22A2
SLC22A2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Renal uptake of substrates for organic anion transporters Oat1 and Oat3 and organic cation transporters Oct1 and Oct2 is altered in rats with adenine-induced chronic renal failure. 23280877

2013

Entrez Id: 10
Gene Symbol: NAT2
NAT2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure. 20007296

2010

Entrez Id: 8678
Gene Symbol: BECN1
BECN1
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach. 24090408

2013

Entrez Id: 4036
Gene Symbol: LRP2
LRP2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Modulation of gene expression by moxonidine in rats with chronic renal failure. 15266031

2004

Entrez Id: 5228
Gene Symbol: PGF
PGF
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Biomarker RGD Microvasculature change and placenta growth factor expression in the early stage of a rat remnant kidney model. 16543713

2006

Entrez Id: 2147
Gene Symbol: F2
F2
CUI: C2316810
Disease: Chronic kidney disease stage 5
Chronic kidney disease stage 5
0.200 Therapeutic RGD 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy. 22473220

2012