×
Entrez Id: 9381
Gene Symbol: OTOF
OTOF
Sensorineural hearing loss, bilateral
0.500
Biomarker
MGD
Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.
16024820 2005
×
Entrez Id: 494513
Gene Symbol: PJVK
PJVK
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy.
16804542 2006
×
Entrez Id: 9294
Gene Symbol: S1PR2
S1PR2
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
The S1P2 sphingosine 1-phosphate receptor is essential for auditory and vestibular function.
16945494 2006
×
Entrez Id: 65217
Gene Symbol: PCDH15
PCDH15
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea.
16972005 2006
×
Entrez Id: 9381
Gene Symbol: OTOF
OTOF
Sensorineural hearing loss, bilateral
0.500
Biomarker
MGD
Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse.
17055430 2006
×
Entrez Id: 10804
Gene Symbol: GJB6
GJB6
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness.
17227867 2007
×
Entrez Id: 25861
Gene Symbol: WHRN
WHRN
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
The deaf mouse mutant whirler suggests a role for whirlin in actin filament dynamics and stereocilia development.
17326148 2007
×
Entrez Id: 64072
Gene Symbol: CDH23
CDH23
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.
17329413 2007
×
Entrez Id: 10804
Gene Symbol: GJB6
GJB6
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis.
17400755 2007
×
Entrez Id: 9381
Gene Symbol: OTOF
OTOF
Sensorineural hearing loss, bilateral
0.500
Biomarker
MGD
A missense mutation in the conserved C2B domain of otoferlin causes deafness in a new mouse model of DFNB9.
17967520 2007
×
Entrez Id: 246213
Gene Symbol: SLC17A8
SLC17A8
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone.
18278042 2008
×
Entrez Id: 246213
Gene Symbol: SLC17A8
SLC17A8
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Impairment of SLC17A8 encoding vesicular glutamate transporter-3, VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell dysfunction in null mice.
18674745 2008
×
Entrez Id: 1690
Gene Symbol: COCH
COCH
Sensorineural hearing loss, bilateral
0.220
Biomarker
MGD
A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction.
18697796 2008
×
Entrez Id: 220074
Gene Symbol: LRTOMT
LRTOMT
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
A catechol-O-methyltransferase that is essential for auditory function in mice and humans.
18794526 2008
×
Entrez Id: 161497
Gene Symbol: STRC
STRC
Sensorineural hearing loss, bilateral
0.310
Biomarker
MGD
Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.
18849963 2008
×
Entrez Id: 10804
Gene Symbol: GJB6
GJB6
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear.
19047635 2008
×
Entrez Id: 64072
Gene Symbol: CDH23
CDH23
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
A mouse model for nonsyndromic deafness (DFNB12) links hearing loss to defects in tip links of mechanosensory hair cells.
19270079 2009
×
Entrez Id: 25861
Gene Symbol: WHRN
WHRN
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape.
20332152 2010
×
Entrez Id: 64072
Gene Symbol: CDH23
CDH23
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
A new mouse mutant of the Cdh23 gene with early-onset hearing loss facilitates evaluation of otoprotection drugs.
20644563 2012
×
Entrez Id: 10804
Gene Symbol: GJB6
GJB6
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice.
20858605 2010
×
Entrez Id: 1690
Gene Symbol: COCH
COCH
Sensorineural hearing loss, bilateral
0.220
Biomarker
MGD
Hearing and vestibular deficits in the Coch(-/-) null mouse model: comparison to the Coch(G88E/G88E) mouse and to DFNA9 hearing and balance disorder.
21073934 2011
×
Entrez Id: 53904
Gene Symbol: MYO3A
MYO3A
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA.
21165622 2011
×
Entrez Id: 64072
Gene Symbol: CDH23
CDH23
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.
21689626 2011
×
Entrez Id: 117531
Gene Symbol: TMC1
TMC1
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Identification of three novel hearing loss mouse strains with mutations in the Tmc1 gene.
22330676 2012
CEACAM16
Sensorineural hearing loss, bilateral
0.200
Biomarker
MGD
Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
22544735 2012