Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. 15026113

2004
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease. 18401023

2008
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN Sialic acid moiety of apolipoprotein E3 at Thr(194) affects its interaction with beta-amyloid(1-42) peptides. 18023277

2008
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN Second, the APOE gene is the only gene so far recognized as a consistent genetic determinant of sporadic forms of AD, even though numerous studies have looked for such genes; these disappointing results suggest persistent methodological limitations. 17659844

2007
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN Studies on the effect of the apolipoprotein E genotype on the lipid profile in Alzheimer's disease. 16611016

2006
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN Diabetes and overweight associate with non-APOE4 genotype in an Alzheimer's disease population. 18189240

2008
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN These data support the hypothesis that APOE4,4 is associated with thinning of the microvascular basement membrane in Alzheimer's disease. 12417381

2002
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN This study suggests that VR22 or a nearby gene influences susceptibility to Alzheimer's disease, and the effect is dependent on APOE status. 16199552

2005
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 Biomarker LHGDN APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study. 15596614

2004
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 PosttranslationalModification LHGDN Neuron-specific proteolytic cleavage of apoE4 is associated with increased phosphorylation of tau and may play a key role in the development of AD-related neuronal deficits. 15014128

2004
Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.700 AlteredExpression LHGDN These results contribute to the evidence that regulation of APOE4 expression modulates risk for Alzheimer's disease. 16314757

2005