Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.600 CausalMutation CGI

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.440 CausalMutation CGI

Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4540293
Disease: IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA
IMMUNODEFICIENCY, DEVELOPMENTAL DELAY, AND HYPOHOMOCYSTEINEMIA 		0.400 GeneticVariation UNIPROT Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder. 29018201

2017
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms 		0.370 Biomarker CTD_human Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. 20722399

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C3241937
Disease: Nonalcoholic Steatohepatitis
Nonalcoholic Steatohepatitis 		0.400 Biomarker CTD_human Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice. 25294219

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease 		0.400 Biomarker CTD_human Activation of the Nrf2-ARE pathway in hepatocytes protects against steatosis in nutritionally induced non-alcoholic steatohepatitis in mice. 25294219

2014
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0162820
Disease: Dermatitis, Allergic Contact
Dermatitis, Allergic Contact 		0.300 Biomarker CTD_human Allergic skin inflammation induced by chemical sensitizers is controlled by the transcription factor Nrf2. 23564646

2013
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 Biomarker CTD_human Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. 18572023

2008
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin 		0.350 Biomarker CTD_human Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. 18572023

2008
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0037286
Disease: Skin Neoplasms
Skin Neoplasms 		0.310 Biomarker CTD_human Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. 18572023

2008
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0149504
Disease: Encephalopathy, Toxic
Encephalopathy, Toxic 		0.300 Therapeutic CTD_human Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. 20211941

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0154659
Disease: Toxic Encephalitis
Toxic Encephalitis 		0.300 Therapeutic CTD_human Astrocyte-specific overexpression of Nrf2 protects striatal neurons from mitochondrial complex II inhibition. 20211941

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.400 Biomarker CTD_human Compared with wild-type mice, mice lacking Nrf2 (Nrf2-null) have lower basal serum insulin and prolonged hyperglycemia in response to an intraperitoneal glucose challenge. 20086057

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0085215
Disease: Ovarian Failure, Premature
Ovarian Failure, Premature 		0.300 Biomarker CTD_human Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. 26247513

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0086367
Disease: Gonadotropin-Resistant Ovary Syndrome
Gonadotropin-Resistant Ovary Syndrome 		0.300 Biomarker CTD_human Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. 26247513

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C3494522
Disease: Hypergonadotropic Ovarian Failure, X-Linked
Hypergonadotropic Ovarian Failure, X-Linked 		0.300 Biomarker CTD_human Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. 26247513

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C4552079
Disease: Premature Ovarian Failure 1
Premature Ovarian Failure 1 		0.300 Biomarker CTD_human Effects of deletion of the transcription factor Nrf2 and benzo [a]pyrene treatment on ovarian follicles and ovarian surface epithelial cells in mice. 26247513

2015
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation. 23441843

2013
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0017178
Disease: Gastrointestinal Diseases
Gastrointestinal Diseases 		0.310 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0022593
Disease: Keratosis
Keratosis 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0022594
Disease: Keratosis Blennorrhagica
Keratosis Blennorrhagica 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0086501
Disease: Keratoma
Keratoma 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0559031
Disease: Functional Gastrointestinal Disorders
Functional Gastrointestinal Disorders 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C1565321
Disease: Cholera Infantum
Cholera Infantum 		0.300 Biomarker CTD_human Genetic analysis of cytoprotective functions supported by graded expression of Keap1. 20404090

2010
Entrez Id: 4780
Gene Symbol: NFE2L2
NFE2L2
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.400 Biomarker CTD_human Genetic knockout of NRF2 demonstrates its role in developmentally regulated γ-globin gene expression and the ability to control oxidative stress and the phenotypic severity of SCD. 29255069

2018