×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
CausalMutation
CGI
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
HPO
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
PI3K /AKT pathway may represent an important therapeutic target for gastric cancer .23058013 2012
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
PIK3CA mutation in GC is a rare finding.29905413 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
PIK3CA mutations were identified in formalin-fixed and paraffin-embedded surgical specimens from 112 patients with EBV-GC with available tumor tissue samples.30952761 2019
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
PI3K /AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer .31816819 2019
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
A case-control study of 1275 GC patients and 1436 controls was performed to explore the associations of potentially functional SNPs in PI3K /Akt/mTOR pathway genes with the risk of GC .
29802999 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
A specific phosphoinositide 3-kinase (PI3K ) inhibitor, wortmannin, was used to test the effect of PI3K inhibition on the secretion of CCL-2 in gastric cancer .
29422964 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Activation of PI3K /Akt pathway may be a key regulatory mechanism of ADAMTS9-AS2 in gastric cancer .
30089248 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
Additionally, we reviewed the rate of PIK3CA mutations in gastric cancer and the association between PIK3CA mutations and prognosis in human cancers.
27388016 2016
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
AdP promoted apoptosis in CDDP-resistant GC cells by suppressing the PI3K /AKT/ARNT signaling pathway and might be considered a candidate agent for the clinical treatment of cisplatin-resistant GC .
29522284 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
AIB1 induces epithelial-mesenchymal transition in gastric cancer via the PI3K /AKT signaling.
31692102 2019
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
All the data showed that high expression of ABL2 suppresses apoptosis through Ras/Erk and PI3K /AKT signaling pathway in GC cell lines.
29767389 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Analysis of correlation between HP infection and activation of PI3K /Akt pathway in mucosal tissues of gastric cancer and precancerous lesions.
30344716 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
Are PIK3CA Mutation and Amplification Associated with Clinicopathological Characteristics of Gastric Cancer ?
26107192 2015
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K /Akt signaling pathway in gastric cancer .
27121204 2016
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
Based on these data, we initiated PIK3CA mutation screening in 94 human gastric cancers by direct sequencing of the gene regions in which 80% of all the known PIK3CA mutations were found.
15784156 2005
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Celecoxib sensitizes gastric cancer to rapamycin via inhibition of the Cbl-b-regulated PI3K /Akt pathway.
25701378 2015
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Clinical value of CagA, c-Met, PI3K and Beclin-1 expressed in gastric cancer and their association with prognosis.
29422968 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Cooperative relationships were identified between PI3K and Akt, and PI3K and survivin (P<0.01), suggesting the involvement of the PI3K /Akt/survivin signaling pathway in the tumorigenesis of gastric cancer .
24726064 2014
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
CXCL10/CXCR3 axis promotes the invasion of gastric cancer via PI3K /AKT pathway-dependent MMPs production.
27470388 2016
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Dual PI3K /mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway.
29374144 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Dual inhibitor of PI3K and mTOR (NVP-BEZ235) augments the efficacy of fluorouracil on gastric cancer chemotherapy.
30275715 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Dysregulated lncRNA-UCA1 contributes to the progression of gastric cancer through regulation of the PI3K -Akt-mTOR signaling pathway.
29212166 2017
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
Everolimus monotherapy was satisfactory in a patient with refractory metastatic GC harboring PIK3CA and pS6 aberrations.
25886409 2015