Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) has been associated with enhanced malignancy in breast cancer, but its functional role in this disease is poorly understood. 10435636

1999

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted glycophosphoprotein which induces migration of mammary carcinoma cells, and has been implicated in the malignancy of breast carcinoma. 10861844

2000

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including cancer development, progression and metastasis. 11520606

2001

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted phosphoprotein that has been associated with malignancy of breast and other cancers. 14517343

2003

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and progression. 14647232

2004

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a phosphorylated glycoprotein with diverse functions including cancer development, progression and metastasis. 14716823

2004

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE OPN induces cell migration in cancer cells, in part through activation of the hepatocyte growth factor (HGF) receptor (Met) and its signaling pathway. 16258259

2005

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. 17148500

2007

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) mediates cancer metastasis. 17689681

2007

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin as a target for cancer therapy. 18508515

2008

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted phosphoprotein that confers on cancer cells a migratory phenotype and activates signaling pathways that induce cell survival, proliferation, invasion, and metastasis. 19358273

2009

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted phosphoprotein that confers on cancer cells a migratory phenotype. 19628079

2009

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a cytokine that contributes substantially to the growth and metastasis in a wide spectrum of malignancies. 19767100

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN), a secreted phosphoglycoprotein, is frequently associated with cell proliferation and tumor metastatic spread in a variety of cancers. 20207476

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression BEFREE SPP1 was found to be significantly upregulated in many kinds of malignant tumors, including gliomas. 20505679

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) has been shown to play many roles in the progression of cancer. 20868520

2010

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted phospho-protein that confers on cancer cells a migratory phenotype. 21630219

2011

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) has been recognized as a significant cytokine in the processes of tumorigenicity, tumor progression and metastasis in many types of human cancer. 21842122

2012

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression BEFREE Osteopontin expression has been associated with breast cancer progression, regardless of the histological subtype of the cancer. 23900428

2013

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is an acidic, glycosylated and phosphorylated protein that plays an essential role in determining the aggressiveness and oncogenic potential of several types of cancer, including lung cancer. 24008322

2013

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a phosphoprotein that activates pathways that induce cancer cell survival and metastasis. 24548099

2014

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin (OPN) is a secreted phosphoprotein expressed by neoplastic cells involved in the malignant potential and aggressive phenotypes of human malignancies, including gastrointestinal stromal tumors (GISTs). 24947165

2014

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE OPN might promote a cancer stem cell-like phenotype via the αvβ3-NF-κB-HIF-1α pathway. 25749383

2015

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE Osteopontin, a secreted glycoprotein, plays a role in cell survival, immunity, and tumor progression, its expression being associated with a poor prognosis and metastasis in several malignancies. 25824779

2015

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker BEFREE OPN and MMPs play a role in cancer development and are prognostic markers in breast cancer progression. 26482249

2015