×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
BEFREE
The hereditary cancer syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and succinate dehydrogenase-related hereditary paraganglioma and pheochromocytoma (SDH PGL/PCC) are linked to germline loss-of-function mutations in genes encoding the Krebs cycle enzymes fumarate hydratase and succinate dehydrogenase, thus leading to elevated levels of fumarate and succinate, respectively<sup>1-3</sup>.
30013182 2018
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Clinical predictors and algorithm for the genetic diagnosis of pheochromocytoma patients.
19825962 2009
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Pheochromocytoma in a Twelve-Year-Old Girl with SDHB-Related Hereditary Paraganglioma-Pheochromocytoma Syndrome.
25215250 2014
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Clinical presentations, biochemical phenotypes, and genotype-phenotype correlations in patients with succinate dehydrogenase subunit B-associated pheochromocytomas and paragangliomas.
17200167 2007
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A comprehensive next generation sequencing-based genetic testing strategy to improve diagnosis of inherited pheochromocytoma and paraganglioma.
23666964 2013
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A case of familial paraganglioma syndrome type 4 caused by a mutation in the SDHB gene.
17143317 2006
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Epithelial to mesenchymal transition is activated in metastatic pheochromocytomas and paragangliomas caused by SDHB gene mutations.
22492777 2012
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Relapsing pheochromocytoma in a Chinese women caused by a novel mutation in exon 6 of the SDHB gene: a case report.
17943698 2007
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD.
19802898 2010
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Mutation analysis of SDHB and SDHC: novel germline mutations in sporadic head and neck paraganglioma and familial paraganglioma and/or pheochromocytoma.
16405730 2006
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Head and neck paragangliomas: genetic spectrum and clinical variability in 79 consecutive patients.
22241717 2012
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
The phenotype of SDHB germline mutation carriers: a nationwide study.
28490599 2017
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A SDHC Founder Mutation Causes Paragangliomas (PGLs) in the French Canadians: New Insights on the SDHC-Related PGL.
27700540 2016
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene.
18840642 2008
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes.
16317055 2006
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.
19522823 2009
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia.
17487275 2007
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Attention Deficit Hyperactivity Disorder in Pediatric Patients with Pheochromocytoma and Paraganglioma.
27171833 2016
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
GeneticVariation
CLINVAR
Association of urinary bladder paragangliomas with germline mutations in the SDHB and VHL genes.
25683602 2015
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Identification of somatic VHL gene mutations in sporadic head and neck paragangliomas in association with activation of the HIF-1α/miR-210 signaling pathway.
23902947 2013
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma.
14685938 2004
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Crystal structure of mitochondrial respiratory membrane protein complex II.
15989954 2005
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Cervical paragangliomas: is SDH genetic analysis systematically required?
17987308 2008
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling.
27604842 2017
×
Entrez Id: 6390
Gene Symbol: SDHB
SDHB
Neoplastic Syndromes, Hereditary
0.110
CausalMutation
CLINVAR
[The mutations of germline succinate dehydrogrnase subunit B (SDHB) in sporadic paragangliomas].
21909610 2011