×
Entrez Id: 494327
Gene Symbol: MIR378A
MIR378A
Non-Small Cell Lung Carcinoma
0.050
Biomarker
BEFREE
"Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis."
23725371 2013
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
BEFREE
"Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer .
21865399 2011
×
Entrez Id: 7124
Gene Symbol: TNF
TNF
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations used:</b> TRAIL: Tumor necrosis factor -related apoptosis-inducing ligand; CLR: Curcumae longae Rhizoma; CR: Coptidis Rhizoma; NSCLC: non-small cell lung cancer .
29720822 2019
×
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
Non-Small Cell Lung Carcinoma
0.080
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5564
Gene Symbol: PRKAB1
PRKAB1
Non-Small Cell Lung Carcinoma
0.070
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5563
Gene Symbol: PRKAA2
PRKAA2
Non-Small Cell Lung Carcinoma
0.070
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK : AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
Non-Small Cell Lung Carcinoma
0.050
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7 : autophagy related 7 ; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1 : beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 10114
Gene Symbol: HIPK3
HIPK3
Non-Small Cell Lung Carcinoma
0.030
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3 ; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3 : homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
Non-Small Cell Lung Carcinoma
0.050
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH : glyceraldehyde-3-phosphate dehydrogenase ; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 3570
Gene Symbol: IL6R
IL6R
Non-Small Cell Lung Carcinoma
0.320
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R : interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
MAP1LC3B
Non-Small Cell Lung Carcinoma
0.040
AlteredExpression
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta ; NSCLC: non-small cell lung cancer ; RFP: red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 5987
Gene Symbol: TRIM27
TRIM27
Non-Small Cell Lung Carcinoma
0.020
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP : red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 2358
Gene Symbol: FPR2
FPR2
Non-Small Cell Lung Carcinoma
0.010
Biomarker
BEFREE
<b>Abbreviations</b> 3-MA: 3-methyladenine; AMPK: AMP-activated protein kinase; ATG7: autophagy related 7; Baf-A: bafilomycin A<sub>1</sub>; BECN1: beclin 1; <i>circHIPK3</i>: circular HIPK3; CQ: chloroquine; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; HIPK3: homeodomain interacting protein kinase 3; IL6R: interleukin 6 receptor; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; NSCLC: non-small cell lung cancer ; RFP : red fluorescent protein; RPS6KB1/S6K: ribosomal protein S6 kinase B1; SQSTM1/p62: sequestosome 1; STAT3: signal transducer and activator of transcription 3; STK11: serine/threonine kinase 11.
31232177 2020
×
Entrez Id: 29126
Gene Symbol: CD274
CD274
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Aims</b>: Immunohistochemistry of PD-L1 has been recently established as a surrogate method to predict if immunotherapy targeting PD-L1/PD-1 has a significant effect on suppression of cancers such as lung non-small cell carcinoma , melanoma, and renal cell carcinoma.
30588196 2018
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
Biomarker
BEFREE
<b>Background</b>: Afatinib is a second-generation epidermal growth factor receptor -tyrosine kinase inhibitor (EGFR -TKI) that has been approved by the Food and Drug Administration for the treatment of advanced non-small cell lung cancer (NSCLC ) harboring EGFR mutations.
30854094 2019
×
Entrez Id: 442906
Gene Symbol: MIR338
MIR338
Non-Small Cell Lung Carcinoma
0.080
AlteredExpression
BEFREE
<b>Background</b>: Circular RNAs (circRNAs) play a pivotal regulatory role in a variety of tumors.Nevertheless, the detailed function of circ_0000003 in non-small cell lung cancer (NSCLC) and its regulatory mechanism remain elusive.<b>Methods</b>: RT-PCR was carried out to detect the expressions of circ_0000003, miR-338 -3p and insulin receptor substrate 2 (IRS2)in NSCLC tissues.
31736412 2019
×
Entrez Id: 8660
Gene Symbol: IRS2
IRS2
Non-Small Cell Lung Carcinoma
0.050
Biomarker
BEFREE
<b>Background</b>: Circular RNAs (circRNAs) play a pivotal regulatory role in a variety of tumors.Nevertheless, the detailed function of circ_0000003 in non-small cell lung cancer (NSCLC) and its regulatory mechanism remain elusive.<b>Methods</b>: RT-PCR was carried out to detect the expressions of circ_0000003, miR-338-3p and insulin receptor substrate 2 (IRS2 )in NSCLC tissues.
31736412 2019
×
Entrez Id: 339896
Gene Symbol: GADL1
GADL1
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Background</b>: MicroRNAs (miRNAs) are becoming recognized as novel diagnostic and prognostic biomarkers in several malignancies, including non-small-cell lung cancer (NSCLC ). miR-25 is overexpressed in small cell lung cancer (SCLC) and NSCLC tissues, and high miR-25 expression is associated with poorer overall survival of women with lung ADC .
30919763 2019
×
Entrez Id: 113451
Gene Symbol: AZIN2
AZIN2
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Background</b>: MicroRNAs (miRNAs) are becoming recognized as novel diagnostic and prognostic biomarkers in several malignancies, including non-small-cell lung cancer (NSCLC ). miR-25 is overexpressed in small cell lung cancer (SCLC) and NSCLC tissues, and high miR-25 expression is associated with poorer overall survival of women with lung ADC .
30919763 2019
×
Entrez Id: 238
Gene Symbol: ALK
ALK
Non-Small Cell Lung Carcinoma
0.600
GeneticVariation
BEFREE
<b>Background:</b> A total of 2%-7% of non-small cell lung cancer (NSCLC ) patients have anaplastic lymphoma kinase (ALK ) mutations.
31190983 2019
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Non-Small Cell Lung Carcinoma
0.500
Biomarker
BEFREE
<b>Background:</b> Purpose of this study was to evaluate the contribution of the Extracellular-regulated protein kinase (ERK)-1/2 pathway to oncogenic signaling elicited by the tyrosine kinase receptor HER2 in Non-Small Cell Lung Cancer (NSCLC ) and to assess the prognostic value of these oncoproteins in NSCLC patients.
28243327 2017
×
Entrez Id: 6513
Gene Symbol: SLC2A1
SLC2A1
Non-Small Cell Lung Carcinoma
0.100
Biomarker
BEFREE
<b>Conclusion</b>: Taken together, our data confirms that GLUT1 promotes the malignant phenotype of NSCLC through integrin β1/Src/FAK signaling, which provides a new therapeutic target for the treatment and research of lung cancer.
31598171 2019
×
Entrez Id: 3688
Gene Symbol: ITGB1
ITGB1
Non-Small Cell Lung Carcinoma
0.360
Biomarker
BEFREE
<b>Conclusion</b>: Taken together, our data confirms that GLUT1 promotes the malignant phenotype of NSCLC through integrin β1 /Src/FAK signaling, which provides a new therapeutic target for the treatment and research of lung cancer.
31598171 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
BEFREE
<b>Conclusion</b>: This retrospective analysis demonstrated that performance status (KPS≥70), absence of ECM metastases, administration of local treatment and chemotherapy were associated with superior OS in patients with EGFR -mutant NSCLC who developed BM.
31293653 2019