Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0431129
Disease: Adamantinous Craniopharyngioma
Adamantinous Craniopharyngioma 		0.360 Biomarker CTD_human Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. 24413733

2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.600 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.600 GeneticVariation UNIPROT

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.700 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.700 Biomarker CTD_human We examined epidermal growth factor receptor (EGFR), Kirsten rate sarcoma viral oncogene homolog (KRAS), v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), human epidermal growth factor receptor 2 (HER2), PIK3CA, v-akt murine thymoma vial oncogene homolog 1 (AKT1), v-ras neuroblastoma viral oncogene homolog (NRAS), dual specificity mitogen-activated protein kinase kinase 1 (MEK1), and anaplastic lymphoma kinase (ALK) in patients with adenocarcinoma of the lung to identify driver mutations. 22135231

2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.700 Biomarker CTD_human Driver gene mutations in BRAF, EGFR, ERBB2, HRAS, KRAS, MET, NRAS, PIK3CA, STK11, and ephrin receptor genes (EPHA1-8, 10 and EPHB1-4, 6) were studied for both LAC and MM, and in BAP1, CUL1, CDKN2A, and NF2 for MM. 26463840

2016
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0007112
Disease: Adenocarcinoma of prostate
Adenocarcinoma of prostate 		0.430 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0206686
Disease: Adrenocortical carcinoma
Adrenocortical carcinoma 		0.420 Biomarker CTD_human Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma. 23585556

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0278875
Disease: Adult Craniopharyngioma
Adult Craniopharyngioma 		0.350 Biomarker CTD_human Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas. 24413733

2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma 		0.400 Biomarker CTD_human In a similar manner, ameloblastoma cells harboring an activating BRAF mutation encoding p.Val600Glu are sensitive to the BRAF inhibitor vemurafenib. 24859340

2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0334579
Disease: Anaplastic astrocytoma
Anaplastic astrocytoma 		0.510 Biomarker CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0334579
Disease: Anaplastic astrocytoma
Anaplastic astrocytoma 		0.510 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.400 Biomarker CTD_human Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. 23817572

2013
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0153943
Disease: Benign neoplasm of stomach
Benign neoplasm of stomach 		0.300 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.500 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0858252
Disease: Breast adenocarcinoma
Breast adenocarcinoma 		0.310 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.400 Biomarker CTD_human Here we show decreasing the levels of CTR1 (Cu transporter 1), or mutations in MEK1 that disrupt Cu binding, decreased BRAF(V600E)-driven signalling and tumorigenesis in mice and human cell settings. 24717435

2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0154060
Disease: Carcinoma in situ of stomach
Carcinoma in situ of stomach 		0.300 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 CausalMutation CGI

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.700 GeneticVariation UNIPROT We sought to determine the frequency of BRAF mutations in human lung cancer pathogenesis. 12460919

2002
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1275081
Disease: Cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous syndrome 		1.000 Biomarker CLINGEN Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. 16439621

2006
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1275081
Disease: Cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous syndrome 		1.000 Biomarker GENOMICS_ENGLAND Noonan syndrome and clinically related disorders. 21396583

2011
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1275081
Disease: Cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous syndrome 		1.000 GeneticVariation UNIPROT Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. 18042262

2008
Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C1275081
Disease: Cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous syndrome 		1.000 Biomarker CLINGEN We recently demonstrated that mice expressing a Braf Q241R mutation, which corresponds to the most frequent BRAF mutation (Q257R) in CFC syndrome, on a C57BL/6J background are embryonic/neonatal lethal, with multiple congenital defects, preventing us from analyzing the phenotypic consequences after birth. 26472072

2015