LINC01672
Liver carcinoma
0.040
GeneticVariation
BEFREE
<b>Abbreviation used:</b> A549 (human lung carcinoma), Caco-2 (Human ColonCarcinoma), CHCl3 (Chloroform), HCT 116 (Human Colon Carcinoma), HepG2 (Liver Hepatocellular Carcinoma ), HT-29 (Human Colorectal Adenocarcinoma), MCF-7 (Michigan Cancer Foundation-7; Human Breast Adenocarcinoma), MeOH (Methanol), NMR Nuclear Magnetic Resonance), PBS (Phosphate Buffered Saline), PC-3 (Human Prostate Cancer), PTLC (Preparative Thin Layer Chromatography), RPMI-1640 (Roswell Park Memorial Institute medium), TLC (ThinLayer Chromatography).
28479724 2017
×
Entrez Id: 26269
Gene Symbol: FBXO8
FBXO8
Liver carcinoma
0.030
Biomarker
BEFREE
<b>Abbreviations used:</b> AC: Acetone extract; ANOVA: Analysis of variance; BSA: Bovine serum albumin; β-TC<sub>3</sub>: Mouse pancreatic β-cells; DMEM: Dulbecco modified Eagle medium; DMSO: Dimethyl sulfoxide; ETH: Ethyl acetate extract; FBS : Fetal bovine serum; HDETH: Hydroethanolic extract; HepG2: Hepatocellular carcinoma cell line; HEX: Hexane extract; INF: Infusion; KUMS: Kermanshah University of Medical Sciences; MMP: Mitochondrial membrane potential; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; NaCl: Natrium chloride; OD: Optical density; spp: Species; STZ: Streptozotocin; Tag: T-antigen; USA: United States of America.
29491644 2018
×
Entrez Id: 64319
Gene Symbol: FBRS
FBRS
Liver carcinoma
0.020
Biomarker
BEFREE
<b>Abbreviations used:</b> AC: Acetone extract; ANOVA: Analysis of variance; BSA: Bovine serum albumin; β-TC<sub>3</sub>: Mouse pancreatic β-cells; DMEM: Dulbecco modified Eagle medium; DMSO: Dimethyl sulfoxide; ETH: Ethyl acetate extract; FBS : Fetal bovine serum; HDETH: Hydroethanolic extract; HepG2: Hepatocellular carcinoma cell line; HEX: Hexane extract; INF: Infusion; KUMS: Kermanshah University of Medical Sciences; MMP: Mitochondrial membrane potential; MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; NaCl: Natrium chloride; OD: Optical density; spp: Species; STZ: Streptozotocin; Tag: T-antigen; USA: United States of America.
29491644 2018
×
Entrez Id: 213
Gene Symbol: ALB
ALB
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations used:</b> MTT: Thiazolyl blue tetrazolium blue; DMSO: Dimethyl sulfoxide; BSA: Bovine serum albumin ; DMEM: Dulbecco's minimum essential medium; NCCS: National Centre for Cell Science; PBS: Phosphate-Buffered Saline; HepG2: Liver hepatocellular carcinoma ; HeLa: Henrietta Lacks cervical carcinoma cells; HCT-116: Human colorectal carcinoma cell line; EAC: Ehrlich ascites carcinoma cells; IC50: Half maximal inhibitory concentration; AO/EB: Acridine orange/Ethidium bromide; BCL-2: B-cell lymphoma 2; BCL-XL: B-cell lymphoma-extra large; MCL-1: Myeloid cell leukemia 1; PDB: Protein Data Bank; ANOVA: Analysis of variance.
29491636 2018
×
Entrez Id: 706
Gene Symbol: TSPO
TSPO
Liver carcinoma
0.050
Biomarker
BEFREE
<b>Abbreviations used:</b> MTT: Thiazolyl blue tetrazolium blue; DMSO: Dimethyl sulfoxide; BSA: Bovine serum albumin; DMEM: Dulbecco's minimum essential medium; NCCS: National Centre for Cell Science; PBS : Phosphate-Buffered Saline; HepG2: Liver hepatocellular carcinoma ; HeLa: Henrietta Lacks cervical carcinoma cells; HCT-116: Human colorectal carcinoma cell line; EAC: Ehrlich ascites carcinoma cells; IC50: Half maximal inhibitory concentration; AO/EB: Acridine orange/Ethidium bromide; BCL-2: B-cell lymphoma 2; BCL-XL: B-cell lymphoma-extra large; MCL-1: Myeloid cell leukemia 1; PDB: Protein Data Bank; ANOVA: Analysis of variance.
29491636 2018
×
Entrez Id: 1131
Gene Symbol: CHRM3
CHRM3
Liver carcinoma
0.040
Biomarker
BEFREE
<b>Abbreviations used:</b> MTT: Thiazolyl blue tetrazolium blue; DMSO: Dimethyl sulfoxide; BSA: Bovine serum albumin; DMEM: Dulbecco's minimum essential medium; NCCS: National Centre for Cell Science; PBS : Phosphate-Buffered Saline; HepG2: Liver hepatocellular carcinoma ; HeLa: Henrietta Lacks cervical carcinoma cells; HCT-116: Human colorectal carcinoma cell line; EAC: Ehrlich ascites carcinoma cells; IC50: Half maximal inhibitory concentration; AO/EB: Acridine orange/Ethidium bromide; BCL-2: B-cell lymphoma 2; BCL-XL: B-cell lymphoma-extra large; MCL-1: Myeloid cell leukemia 1; PDB: Protein Data Bank; ANOVA: Analysis of variance.
29491636 2018
×
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> Atg5 : autophgy related 5; DKO: double-knockout; HCC: hepatocellular carcinoma ; INS: insulin; INSR: insulin receptor; KEAP1: kelch-like ECH-associated protein 1; KO: knockout; MTOR: mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid 2 like 2; raptor: regulatory associated protein of MTOR, complex 1; SQSTM1: sequestosome 1: tsc1: TSC complex subunit 1.
31216956 2019
×
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
Liver carcinoma
0.400
Biomarker
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH : glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1: glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase; HCC: hepatocellular carcinoma ; HGF: hepatocyte growth factor; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma ; LIR: LC3-interacting region; PDH: pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 2744
Gene Symbol: GLS
GLS
Liver carcinoma
0.090
Biomarker
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1 : glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase; HCC: hepatocellular carcinoma; HGF: hepatocyte growth factor; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma ; LIR: LC3-interacting region; PDH: pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 2821
Gene Symbol: GPI
GPI
Liver carcinoma
0.050
Biomarker
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1: glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase ; HCC: hepatocellular carcinoma ; HGF: hepatocyte growth factor; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma; LIR: LC3-interacting region; PDH: pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 3082
Gene Symbol: HGF
HGF
Liver carcinoma
0.400
Biomarker
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1: glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase; HCC: hepatocellular carcinoma ; HGF : hepatocyte growth factor ; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma ; LIR: LC3-interacting region; PDH: pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 54704
Gene Symbol: PDP1
PDP1
Liver carcinoma
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1: glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase; HCC: hepatocellular carcinoma ; HGF: hepatocyte growth factor; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma; LIR: LC3-interacting region; PDH : pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 10871
Gene Symbol: CD300C
CD300C
Liver carcinoma
0.020
AlteredExpression
BEFREE
<b>Abbreviations:</b> ALDO: aldolase, fructose-bisphosphate; CQ: chloroquine; DLAT/PDCE2: dihydrolipoamide S-acetyltransferase; EMT: epithelial-mesenchymal transition; ENO: enolase; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GLS/GLS1: glutaminase; GLUL/GS: glutamine-ammonia ligase; GPI/PGI: glucose-6-phosphate isomerase; HCC: hepatocellular carcinoma; HGF: hepatocyte growth factor; HK: hexokinase; LDH: lactate dehydrogenase; LIHC: liver hepatocellular carcinoma ; LIR : LC3-interacting region; PDH: pyruvate dehydrogenase; PDHA1: pyruvate dehydrogenase E1 alpha 1 subunit; PDHX: pyruvate dehydrogenase complex component X; PFK: phosphofructokinase; PK: pyruvate kinase; RTK: receptor tyrosine kinase; TCGA: The Cancer Genome Atlas.
30786811 2019
×
Entrez Id: 3630
Gene Symbol: INS
INS
Liver carcinoma
0.050
Biomarker
BEFREE
<b>Abbreviations:</b> Atg5: autophgy related 5; DKO: double-knockout; HCC: hepatocellular carcinoma ; INS : insulin; INSR: insulin receptor; KEAP1: kelch-like ECH-associated protein 1; KO: knockout; MTOR: mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid 2 like 2; raptor: regulatory associated protein of MTOR, complex 1; SQSTM1: sequestosome 1: tsc1: TSC complex subunit 1.
31216956 2019
×
Entrez Id: 2475
Gene Symbol: MTOR
MTOR
Liver carcinoma
0.400
AlteredExpression
BEFREE
<b>Abbreviations:</b> Atg5: autophgy related 5; DKO: double-knockout; HCC: hepatocellular carcinoma ; INS: insulin; INSR: insulin receptor; KEAP1: kelch-like ECH-associated protein 1; KO: knockout; MTOR : mechanistic target of rapamycin kinase; NFE2L2: nuclear factor, erythroid 2 like 2; raptor: regulatory associated protein of MTOR, complex 1; SQSTM1: sequestosome 1: tsc1: TSC complex subunit 1.
31216956 2019
×
Entrez Id: 115908
Gene Symbol: CTHRC1
CTHRC1
Liver carcinoma
0.070
AlteredExpression
BEFREE
<b>Abbreviations:</b> miRNAs: MicroRNAs; PPP1R15B: PPP1R15B: Protein Phosphatase 1 Regulatory Subunit 15B; TGFβR1: Transforming Growth Factor Beta Receptor 1; ER: Endoplasmic Reticulum; Bip: Binding Immunoglobulin Protein; Chop: CCAAT-enhancer-binding protein homologous protein; p-eIF2α: Eukaryotic Translation Initiation Factor 2a; Bax: Bcl2-associated X protein; Bcl-2: B-cell CLL/lymphoma 2; PCNA: Proliferating Cell Nuclear Antigen; K5: Cytokeratin 5; qRT-PCR: Quantitative Real-Time PCR; ESCC: Oesophageal squamous cell carcinoma; HCC: Hepatocellular carcinoma ; CTHRC1 : Collagen triple helix repeat containing 1; SALL4: Sal-like protein 4; TNFα: Tumour Necrosis Factor alpha; PGC-1β: Peroxisome Profilerator-activated receptor-γ coactivator-1β; IGF2BP1: Insulin-like growth factor 2 mRNA binding protein 1.
31615341 2020
×
Entrez Id: 213
Gene Symbol: ALB
ALB
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Background</b>: Serum globulin (GLB), albumin (ALB ) and albumin/globulin ratio (AGR) have been reported as prognosis related factors for certain malignancies; however, the prognostic value of globulin (GLB) in hepatocellular carcinoma (HCC ) has rarely been studied.
31293654 2019
×
Entrez Id: 55616
Gene Symbol: ASAP3
ASAP3
Liver carcinoma
0.040
Biomarker
BEFREE
<b>Background:</b> ASAP3 was first identified as a protein that promotes cell proliferation in hepatocellular carcinoma and later reported to be an Arf6-specific Arf GTPase-activating protein that regulates cell migration associated with cancer cell invasion.
31410024 2019
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Liver carcinoma
0.600
Biomarker
BEFREE
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K/Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
31406464 2019
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Liver carcinoma
0.800
Biomarker
BEFREE
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K /Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
31406464 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K /Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
31406464 2019
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K /Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
31406464 2019
×
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
Liver carcinoma
0.100
Biomarker
BEFREE
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K /Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
31406464 2019
×
Entrez Id: 382
Gene Symbol: ARF6
ARF6
Liver carcinoma
0.030
Biomarker
BEFREE
<b>Background:</b> ASAP3 was first identified as a protein that promotes cell proliferation in hepatocellular carcinoma and later reported to be an Arf6 -specific Arf GTPase-activating protein that regulates cell migration associated with cancer cell invasion.
31410024 2019
×
Entrez Id: 22915
Gene Symbol: MMRN1
MMRN1
Liver carcinoma
0.040
Biomarker
BEFREE
<b>Background:</b> Liver fibrosis is a chronic liver disease associated with an excessive accumulation of extracellualr matrix (ECM ) proteins which ultimately lead to cirrohosis and hepatocellular carcinoma .
31118614 2019