×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
CITED4 inhibits hypoxia-activated transcription in cancer cells, and its cytoplasmic location in breast cancer is associated with elevated expression of tumor cell hypoxia-inducible factor 1alpha.
15342390
2004
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer.
18949419
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
Rare variant of hypoxia-inducible factor-1alpha (HIF-1A) and breast cancer risk in Korean women.
18160046
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
Mutation analysis of the HIF-1alpha oxygen-dependent degradation domain in invasive breast cancer.
16337862
2005
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
Single nucleotide polymorphisms in the hypoxia-inducible factor-1alpha (HIF-1alpha) gene in human sporadic breast cancer.
18279708
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
GeneticVariation
LHGDN
High frequency of HIF-1alpha overexpression in BRCA1 related breast cancer.
18030615
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
LHGDN
Hypoxia-inducible factor 1alpha is closely linked to an aggressive phenotype in breast cancer.
17805961
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α ).
29959560
2018
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression.
29180628
2017
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
In addition, we have found that factor 26 (1q CNA) is negatively correlated with HIF-1alpha protein and hypoxia pathways in breast tumors and cell lines.
20824128
2010
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF-1α -induced pro-angiogenic factor.
29532562
2018
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1α - and AP-1-mediated VEGFa transcription.
26287601
2015
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α -mediated VEGF-dependent angiogenesis.
23728336
2014
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Ad.Delta55.HRE treatment exhibited significant antitumor activity in PC-3 prostate- and MDA-MB-435 breast tumor -bearing nude mice in which HIF-1alpha protein was immunohistochemically detected.
15509511
2004
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
LHGDN
Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.
14559790
2003
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
Oncostatin M upregulates HIF-1α in breast tumor associated macrophages independent of intracellular oxygen concentration.
29246543
2018
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
LHGDN
Correlation between the expression of aquaporin 1 and hypoxia-inducible factor 1 in breast cancer tissues.
18563339
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
CTD_human
Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1α.
24349381
2013
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
Biomarker
BEFREE
GPER is a transcriptional target of hypoxia inducible factor 1 alpha (HIF-1α ) and activates VEGF expression and angiogenesis in hypoxic breast tumor microenvironment.
29212519
2017
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
In this study, we stably transfected human breast tumor MCF-7 cells with short hairpin RNA expression vectors targeting HIF-1alpha .
16516853
2006
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
The NCI Open Repository of marine invertebrates and algae lipid extracts was evaluated for HIF-1 inhibitory activity in a T47D human breast tumor cell-based reporter assay.
17958397
2007
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Hypoxia-inducible factor-1alpha is associated with angiogenesis, and expression of bFGF, PDGF-BB, and EGFR in invasive breast cancer.
15656883
2005
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Extracellular matrix and HIF-1 signaling: the role of prolidase.
17999410
2008
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
BEFREE
Last, clinically relevant correlations between miR-18a, HIF1A , hypoxia-responsive gene expression and distant metastasis-free survival (DMFS) were assessed using published expression array breast tumors data sets.
25069832
2014
×
Entrez Id:
3091
Gene Symbol:
HIF1A
HIF1A
Mammary Neoplasms
0.400
AlteredExpression
LHGDN
Basic FGF augments hypoxia induced HIF-1-alpha expression and VEGF release in T47D breast cancer cells.
17676480
2007