Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Although antagonizing VEGF has been proposed as a therapeutic approach to limit corneal angiogenesis, alternative targets are needed. 19208899

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE KH906, a recombinant human VEGF receptor fusion protein, is a new effective topical treatment for corneal neovascularization. 21528000

2011

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Conditioned medium from the CEACAM1-expressing cells but not control luciferase-expressing cells inhibited endothelial cell migration up a gradient of stimulatory vascular endothelial growth factor in vitro and inhibited corneal neovascularization induced by basic fibroblast growth factor in vivo. 12122002

2002

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE The purpose of the study is to evaluate the usefulness of OCTA to monitor regression of corneal vessels following anti-VEGF (vascular endothelial growth factor) treatment using a previously established corneal vascularisation rabbit model. 31772259

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE These include inhibitory effects on proinflammatory mediators, such as IL-1β, IL-6, IL-12, CXCL1, MCP-1, MIP-2, vascular endothelial growth factor (VEGF)-A, matrix metalloproteinase 9 (MMP-9), and proinflammatory miRNA, such as miR-155, miR-132, and miR-223, which are involved in SK pathogenesis and corneal neovascularization. 28584076

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE VEGF-A siRNA could potentially serve as an important therapeutic alternative in the management against unwanted angiogenesis including corneal neovascularization. 20450250

2010

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE VEGF is one of the critical mediators of corneal neovascularization but current anti-VEGF therapies have produced limited results in the cornea. 30646013

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE In a rat corneal vascularization model, DT18 demonstrated significant and specific antiangiogenic activity, as evidenced by the reduced area and vessel number in VEGF-induced corneal angiogenesis. 24306423

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE The blockade of vascular endothelial growth factor (VEGF) action has been recognized as an efficient strategy for treating corneal neovascularization. 28740387

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE These novel findings indicate that epithelium-derived miR-204 inhibits suture-induced CNV through regulating VEGF and VEGF receptor 2. 29246498

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Histopathological analysis and the expression level of the pro-angiogenic genes vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP9) revealed that chronic nicotine administration enhanced alkali burn-induced corneal neovascularization. 28644870

2017

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Gli3-deficient mice also displayed reduced capillary density after induction of hindlimb ischemia and an impaired angiogenic response to vascular endothelial growth factor in the corneal angiogenesis model. 19729595

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE To explore the correlation between the level of Angiotensin II (Ang II) and corneal angiogenesis, the rat model of CRNV was established using alkali-burn, while the human umbilical vein endothelial cells (HUVECs) were stimulated using VEGF to induce the CRNV cells in vitro. 30782069

2020

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Herpes simplex virus (HSV) causes a chronic immuno-inflammatory response in the eye that may result in corneal neovascularization during blinding immunopathological lesion stromal keratitis (SK). miR-132 is a highly conserved miRNA that is induced in endothelial cells in response to growth factors, such as vascular endothelial growth factor (VEGF). 22659469

2012

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE The long-term effect of tacrolimus on alkali burn-induced corneal neovascularization and inflammation surpasses that of anti-vascular endothelial growth factor. 30254425

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Topical administration of the three axitinib concentrations inhibited CNV in rabbits, blocking both vascular endothelial growth factor and platelet-derived growth factor pathways. 29888852

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Using B6.A consomic strains, we determined that chromosome 7 bears a locus that inhibits VEGF-induced corneal neovascularization. 23423728

2013

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Ginsenoside Rh2 inhibits vascular endothelial growth factor-induced corneal neovascularization. 29465315

2018

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE The aim of the present study was to evaluate the ability of HGF and KGF to influence VEGF and its receptor, kinase insert domain receptor (Flk‑1) in corneal injury and CNV in rats induced by ultraviolet radiation (UVR). 30816491

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Tear film levels of interleukin- (IL-) 6, IL-8, and vascular endothelial growth factor (VEGF) were investigated over time, and preoperative concentrations were linked to corneal neovascularization and pterygium size. 31780873

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE The results from <i>in vivo</i> tests such as ocular vessels observation, hematoxylin & eosin (H&E) stain, and metalloproteinases (MMP)/vascular endothelial growth factor (VEGF) quantification revealed the mice's eyes with corneal NV treated by eye drops containing GNP-KA once daily for 7 days had better therapeutic effects with less vessels in-growths in the cornea, compared to the KA solution group by reducing the production of MMP and VEGF in the cornea. 31795237

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE Therefore, blocking the binding of VEGF and the corresponding receptor has become critical for inhibiting corneal neovascularization. 17692288

2007

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE ICAM-1 has been identified as a mediator of inflammatory and VEGF-dependent corneal neovascularization. 19482023

2009

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE In addition, VEGF-induced corneal angiogenesis and tumor development were significantly inhibited in mice lacking Akt1. 30984553

2019

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0085109
Disease: Corneal Neovascularization
Corneal Neovascularization
0.400 Biomarker BEFREE This work investigated whether the presence of a proven antiangiogenic factor, the soluble variant of the VEGF receptor, sFlt-1, in the anterior chamber is sufficient to inhibit new vessel formation in the cornea in an animal model of corneal neovascularization. 11440623

2001