Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE However,the interferon-gamma release assay (IGRA) of the ascites was positive after specific stimulation with mycobacterial antigens(ESAT-6/CFP-10/TB7.7[p4]), indicating an infection with MTB.The diagnosis of tuberculosis was later confirmed by histology, MTB culture, and PCR analysis of MTB-complex DNA in tissue samples taken during laparoscopy. 19904487

2010

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE In patients with positive ELISpot in pleural fluid (n = 16), the PPV for TB was 85.7%, which increased to 91.7% for the ESAT-6 panel and 92.3% for the CFP-10 panel after the introduction of a cut-off >1.0 for the ratio between the pleural fluid and blood interferon-gamma responses. 28024452

2017

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE Multicolor flow cytometry analysis of whole-blood cultures showed higher Lpd-specific Th1 recall response (IFN-γ, TNF-α, and IL-2; <i>P</i> = 0.0006) and memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells (CCR7<sup>+</sup> CD45RA<sup>-</sup> and CCR7<sup>-</sup> CD45RA<sup>-</sup>) in healthy household contacts (HHC) of TB (<i>P</i> < 0.0001), which is comparable with or higher than the standard antigens, ESAT-6 and CFP-10. 28428201

2017

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE In order to identify immunodominant antigens of Mycobacterium tuberculosis that may be used in the serodiagnosis of active tuberculosis (TB), we designed an M. tuberculosis fusion protein consisting of CFP-10 (10-kDa culture filtrate protein), ESAT-6 (6-kDa early secreted antigenic target), and the extracellular domain fragment of PPE68 (PPE68'). 22357648

2012

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Here, we studied human pulmonary T-cell responses induced by the <i>M. tuberculosis</i>-specific antigen Rv3615c, a protein with a similar size and sequence homology to ESAT-6 and CFP-10, which induced dominant CD4<sup>+</sup> T-cell responses in human tuberculosis (TB) models. 28588103

2017

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Our results demonstrated that significantly higher levels of polyfunctional CD4(+) T cells for the epitopes of ESAT-6 or CFP-10 in PFCs may play an important role in the local control of tuberculosis (TB) infection. 22154006

2012

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Replacing Trp(55) (W55) or Gly(57) (G57) residues in the putative W-X-G motif of EspA with arginines impaired ESAT-6 and CFP-10 secretion in vitro and attenuated M. tuberculosis. 24078612

2013

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Thus, as for IGRA assays such as Quantiferon and T-Spot TB tests, ESAT-6 and CFP-10 are unable to distinguish LTBI from active TB when IL-2 is measured. 29856871

2018

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Highest diagnostic accuracies for active TB (AUC ≥ 0.91) were achieved for: (i) CD27 within IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells in response to ESAT-6/CFP-10, (ii) CD27 and CCR4 markers together within IFN-γ<sup>+</sup>CD4<sup>+</sup> T-cells in response to PPD, and (iii) CD27 MFI ratio performed on IFN-γ<sup>+</sup>TNF-α<sup>+</sup>CD4<sup>+</sup> T-cells after ESAT-6/CFP-10 stimulation. 30687314

2018

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE The use of genetically detoxified Bordetella pertussis adenylate cyclase toxin (CyaA) as a delivery system for two immunodominant proteins of M. tuberculosis that are of greater specificity than PPD, early-secreted antigenic target 6-kDa protein (ESAT-6) and culture filtrate protein 10 (CFP-10), was therefore investigated. 15845506

2005

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Taken together, ESAT-6/CFP-10 cytokine tests together with detecting IgG antibodies specific to ESAT-6 and CFP-10 may be the useful TB disease biomarkers in monitoring treatment success. 20624776

2010

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE For patients who received combination therapy with medium/high doses of corticosteroids, the T-SPOT.TB positive rate (p = 0.046) and CFP-10 spot number (p = 0.041) were increased after treatment, with no significant changes in the total number of spots or ESAT-6 spots. 30917713

2019

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE This method exhibits great application potential in the field of nanomedical science for highly reliable point-of-care detection of CFP-10 antigen in real samples to early diagnosis of tuberculosis. 30205244

2018

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE In contrast, responses to latency antigens were observed in individuals with suspected exposure to TB (as indicated by positive gamma interferon responses to TB-specific antigens ESAT-6 and CFP-10) and in mice vaccinated with plasmid DNA encoding selected latency antigens. 17502400

2007

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE An electrochemical aptamer-based assay is described for the determination of CFP-10 which is an early secretary biomarker of Mycobacterium tuberculosis. 31473812

2019

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE This study confirms the high conservation for ESAT-6, CFP-10 and EspC in local M. bovis field isolates and reinforce the use of these three antigens in the diagnosis of bovine tuberculosis. 30029900

2018

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Also, in this research, we proposed the incorporation of protein biomarker, Mycobacterium tuberculosis ESAT-6-like protein esxB (CFP-10), as a means of TB detection using plasmonic ELISA. 29899214

2018

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE In addition, we compared the levels of A antigen (ESAT-6) and B antigen (CFP-10) in active TB. 28345545

2017

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Improved diagnosis of tuberculosis in HIV-positive patients using RD1-encoded antigen CFP-10. 19119038

2009

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE At the cellular level, only 2 of 45 mouse T-cell hybridomas raised against either M. leprae or M. tuberculosis CFP-10 displayed a cross-reactive response against the N-terminal heterologous CFP-10 peptide, the region that exhibits the highest level of identity in the two proteins; however, the majority of peptide epitopes recognized by mouse T-cell hybridomas specific for each protein did not cross-react with heterologous peptides. 15155617

2004

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Our results demonstrated for the first time that ESAT-6- and CFP-10-specific Th1, Th22 and Th17 cells existed in the patients with TBP and might play an essential role against M. tuberculosis infection. 21223348

2011

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE The sensitivity of the IgG test ranged from 69.4% (ESAT-6) to 77.6% (ESAT-6/14KD/38KD) in the active TB patients; the specificity of assays varied from 78.4% (CFP-10) to 90.2% (14KD+38KD) in the healthy control groups. 23338746

2013

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Immunoblot analysis demonstrated that CFP-10 is present in M. tuberculosis CFP, indicating that it is likely a secreted or shed antigen. 10970372

2000

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques. 28115506

2017

Entrez Id: 5199
Gene Symbol: CFP
CFP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Detection of LAM and CFP-10 biomarkers in urinary EVs of TB patients by I-PCR showed superiority over ELISA. 31549171

2019