×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
AlteredExpression
BEFREE
6-BG is being tested as an approach to treat CENU-resistant tumors that overexpress endogenous MGMT .
10454526 1999
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
Tumor tissue was analyzed for the presence of chromosomal deletions on 1p and 19q and for MGMT -promoter methylation.18779504 2009
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
Tumor biopsies revealed the epigenetic silencing of MGMT in 42.5% (17 of 40) of patients and of TIMP3 in 40.5% (17 of 42) of cases.19148529 2009
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
Tumor grade correlated positively with MGMT and RARbeta methylation (P = 0.005 and P = 0.019, respectively) and the extent of necrosis (P = 0.001 and P = 0.003).19809523 2010
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
GeneticVariation
BEFREE
Tumor O-6-methylguanine-DNA methyltransferase (MGMT ) promoter was unmethylated in all nine patients analyzed including from the two CR patients.20080829 2010
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
AlteredExpression
BEFREE
Tumor tissue was assayed to determine MGMT promoter methylation status.21252041 2011
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
AlteredExpression
BEFREE
Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients.21865140 2011
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
Tumour MGMT promoter methylation was seen in 73 (35%) of 209 patients tested.22578793 2012
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
GeneticVariation
BEFREE
Tumours are responsive to temozolomide (TMZ) if they are deficient in O(6)-methylguanine-DNA methyltransferase (MGMT ), and mismatch repair (MMR) proficient.22976800 2012
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
AlteredExpression
BEFREE
Tumor tissue was assessed for the expression of EGFRvIII and MGMT promoter methylation by RT-PCR, and for PTEN and VEGF expression by immunohistochemistry.23132371 2013
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
Tumor and serum samples were screened for MGMT promoter methylation.23443801 2013
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
Tumor purity positively and significantly correlated with the extent of methylation in MGMT methylated GBMs.28148826 2017
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
Tumor suppressor MGMT had two DMRs and was downregulated.29059699 2018
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
Tumor suppressor gene O<sup>6</sup>-methylguanine-DNA methyltransferase (<i>MGMT</i>) promoter methylation has been reported in melanoma.29606808 2018
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
Tumor growth patterns of MGMT -non-methylated glioblastoma in the randomized GLARIUS trial.29808316 2018
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
AlteredExpression
BEFREE
MGMT activity was significantly lower in tumors with wild-type p53 (p53wt) than in tumors with mutant p53 (p53mt) (p = 0.045).10404091 1999
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT promoter hypermethylation was present significantly more often in tumors with a G to A mutation in p53 (9 of 14; 64%) than in tumors with other types of p53 mutations (11 of 41; 27%; P = 0.02) or in tumors with wild-type p53 (7 of 37; 18%; P = 0.006).11719438 2001
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT methylation was associated significantly with lymph node invasion (P < 0.01), tumor stage (P < 0.03) and 5-year disease free survival (P < 0.02).11753949 2001
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT promoter methylation was found in 21 (43%) of the 49 tumors .12744471 2003
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT methylation targeted both precursor B-cell neoplasia (23.8%) and mature B-cell tumors (27.6%).15003890 2004
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT promoter methylation was observed in 50% of the analyzed tumors .16033832 2005
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
MGMT is epigenetically silenced in various human tumors .16094446 2005
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
O6-methylguanine-DNA methyltransferase (MGMT ) gene-promoter methylation in the tumor tissue was associated with longer PFS (P = .014, log-rank test) and MST (P = .037).16983109 2006
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
PosttranslationalModification
BEFREE
MGMT promoter methylation is more pronounced at tumor progression, particularly in tumors with an intact 1p.17332285 2007
×
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
Neoplasms
0.100
Biomarker
BEFREE
MGMT was hypermethylated in 50% (10 of 20), DAP-K in 45% (9 of 20), and p16 in 20% (4 of 20) of tumors .17785562 2007