POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs).
|
22014056 |
2011 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
As OCT3 expression was detected only in the breast cancerous cells, this embryonic transcription factor could play an important role in mammary gland carcinogenesis.
|
10077160 |
1999 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Here we present basic information about the OCT4 gene, its isoforms and pseudogenes besides discussing the current literature in which OCT4 is linked to cancer, emphasizing its roles in tumorigenesis and therapy.
|
27788386 |
2016 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Thus, the mammosphere-formation efficiency (MFE) and the self-renewal capacity in vitro, and oncogenicity in vivo in Twist-positive breast cancer cells are elevated. lncRNA-Hh silence in Twist-positive breast cells attenuates the activated Shh-GLI1 signaling and decreases the CSC-associated SOX and OCT4 levels, thus reduces the MFE and tumorigenesis of transplanted tumor.
|
26418365 |
2016 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
TSSC3 was expressed at a low level in T-ICs, while overexpression of TSSC3 could efficiently downregulate the expression of stem cell markers Nanog, Oct4 and Sox2 in T-ICs and decrease the clone formation rate, as well as downregulate tumorigenesis in MThFOB1.19 cells, supporting a suppressive role for TSSC3 in OS T-ICs.
|
22610481 |
2012 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Cripto-1 and OCT4, expressed in stem cells and cancers, play important roles in tumorigenesis.
|
29223130 |
2018 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Our findings suggest that Oct4+Sox2+ cells may be reprogrammed cancer stem cells inducing oral carcinogenesis.
|
27279579 |
2016 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells.
|
30643464 |
2019 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Correction to: Post-translational modification of OCT4 in breast cancer tumorigenesis.
|
31641242 |
2019 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
These results suggest three points: (1) Oct4 might be treated as a new target for the treatment of cervical cancer, (2) we could not inhibit the expression of Oct4 by DNA demethylation, and (3) HPV virus might initiate cervical carcinogenesis by upregulation of Oct4 expression.
|
21674242 |
2011 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
The OSCC cell line H103 which was able to be reprogrammed into an iPSC like state showed high expression of Oct4, Sox2 and Nanog at late passage and may provide a potential iPSC model to study multi-stage oncogenesis in OSCC.
|
28417059 |
2017 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
GeneticVariation |
BEFREE |
All data demonstrated a distinctive expression pattern of OCT4 spliced variants in different types of breast cancer and provide further evidence for the involvement of embryonic genes in carcinogenesis.
|
27814277 |
2017 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
To understand the molecular mechanism by which OCT4 and GDF3 function in tumorigenesis as well as stemness, we investigated the transcriptional regulation of GDF3 mediated by OCT4 in human embryonic carcinoma (EC) NCCIT cells, which are pluripotent stem cells of TGCTs.
|
27803451 |
2016 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
However, the role of Oct4 in tumorigenesis and progression of hepatocellular carcinoma (HCC) has not yet been fully elucidated.
|
29901157 |
2018 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Our study reveals a novel mechanism by which Oct4 transcriptionally activates NEAT1 via promoter and MALAT1 via enhancer binding to promote cell proliferation and motility, and led to lung tumorigenesis and poor prognosis.
|
28615056 |
2017 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
OCT4 has been detected in several human tumors suggesting a potentially critical role in tumorigenesis.
|
19126554 |
2009 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Post-translational modification of OCT4 in breast cancer tumorigenesis.
|
29511337 |
2018 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
OCT4 is a transcription factor known for its regulatory roles in stemness, tumorigenesis and stress response.
|
31182783 |
2019 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Active histone marks especially H3K4me3 and H3K9acS10p were enriched in the promoter region with very low levels of repressive marks H3K9me3 and H3K27me3 indicating that active histone modifications are the deciding factor in inducing over-expression of OCT4 during breast carcinogenesis.
|
29203199 |
2018 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
These data are consistent with the cancer stem cell model of tumorigenesis in osteosarcoma and implicate a functional link between the capacity to activate an exogenous Oct-4 promoter and tumor formation.
|
19584295 |
2009 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
In this study, we demonstrated how the cleaved intracellular domain of CD44 (CD44ICD) activates stemness factors such as Nanog, Sox2 and Oct4, and contributes to the tumorigenesis of breast cancer.
|
25909162 |
2015 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
Oct-4 pseudogenes also contribute to carcinogenesis.
|
20139178 |
2010 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
Biomarker |
BEFREE |
OCT4 and SOX2 are biomarkers of tumorigenesis and early stage OSCC.
|
26211876 |
2016 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
Studies revealed that the methylation level in the basal promoter region of OCT3 was associated with OCT3 expression level and tumorigenesis capability in various prostate cancer cell lines.
|
22231567 |
2013 |
POU5F1P3
|
Carcinogenesis
|
0.100 |
AlteredExpression |
BEFREE |
These observations indicate that OCT3 protein is selectively expressed in human breast cancer cells, and its expression may be implicated in mammary gland tumorigenesis via up-regulating FGF-4 expression.
|
12841847 |
2003 |