|
IGHV3OR16-7
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker |
BEFREE |
Here, we compared the BCR repertoire in systemic lupus erythematosus, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, Crohn's disease, Behçet's disease, eosinophilic granulomatosis with polyangiitis, and immunoglobulin A (IgA) vasculitis by analysing BCR clonality, use of immunoglobulin heavy-chain variable region (IGHV) genes and-in particular-isotype use.
|
31554970 |
2019 |
|
IGHV3OR16-7
|
Leukemia, Prolymphocytic, B-Cell
|
0.010 |
GeneticVariation |
BEFREE |
The majority of B-PLL used the IGHV3 or IGHV4 subgroups (89%) and displayed significantly mutated IGHV genes (79%).
|
31527074 |
2019 |
|
IGHV3OR16-7
|
Monocytoid B-cell lymphoma
|
0.010 |
Biomarker |
BEFREE |
Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL.
|
31802229 |
2019 |
|
IGHV3OR16-7
|
Neoplasms, Second Primary
|
0.010 |
GeneticVariation |
BEFREE |
At diagnosis, very young patients had a similar rate of adverse cytogenetics, IGHV mutation and ZAP70 expression and had lower beta-2-microglobulin and a lower incidence of second malignancies.
|
29316456 |
2018 |
|
IGHV3OR16-7
|
Epstein-Barr Virus Infections
|
0.010 |
Biomarker |
BEFREE |
Binet stage, blood lymphocyte level, TP53 abnormality, unmutated IGHV, prior HBV, and EBV infections were independently associated with TTT in multivariate analyses.
|
29901220 |
2018 |
|
IGHV3OR16-7
|
Adrenoleukodystrophy
|
0.010 |
AlteredExpression |
BEFREE |
In the liver of PBC and ALD patients, (i) roughly 10% of the B lymphocytes were clonally related and highly expressed, and there were also lineages that underwent extensive clonal expansion; (ii) there was different use of IGHV/IGHJ segments between PBC and ALD, suggesting distinct Ag exposure backgrounds, but this did not lead to a significant difference in their clonal expansion level.
|
28834158 |
2018 |
|
IGHV3OR16-7
|
Composite Lymphoma
|
0.010 |
GeneticVariation |
BEFREE |
Clonal relationships in CL and DL are commonly investigated by molecular analysis using mutational status with t(14;18)BCL2/IgH translocation and immunoglobulin heavy chain variable-region (IgV<sub>H</sub>) gene rearrangement.
|
29177642 |
2018 |
|
IGHV3OR16-7
|
Granulomatosis with polyangiitis
|
0.010 |
GeneticVariation |
BEFREE |
Selection against amino acid exchanges was prominent in the framework region of IGHV clones from GPA tissue.
|
30054207 |
2018 |
|
IGHV3OR16-7
|
Angioimmunoblastic Lymphadenopathy
|
0.010 |
Biomarker |
BEFREE |
Investigation of four AITLs by TET2 and IGHV gene sequencing of single microdissected B cells showed that between 10% and 60% of polyclonal B cells in AITL lymph nodes harboured the identical TET2 mutations of the respective T-cell lymphoma clone.
|
28337768 |
2017 |
|
IGHV3OR16-7
|
T-Cell Lymphoma
|
0.010 |
GeneticVariation |
BEFREE |
Investigation of four AITLs by TET2 and IGHV gene sequencing of single microdissected B cells showed that between 10% and 60% of polyclonal B cells in AITL lymph nodes harboured the identical TET2 mutations of the respective T-cell lymphoma clone.
|
28337768 |
2017 |
|
IGHV3OR16-7
|
Hypogammaglobulinemia
|
0.010 |
Biomarker |
BEFREE |
Late onset HGG, more frequently recorded in patients with Rai stage I-II (p=0.001) and unmutated IGHV (p=0.001), was also associated with a higher rate of severe infections (p=0.002).
|
28292720 |
2017 |
|
IGHV3OR16-7
|
Lymphadenopathy
|
0.010 |
Biomarker |
BEFREE |
This association was maintained after adjusting for either FISH [hazard ratio (HR) 2·18; 95% CI 1·25-3·81; P = 0·006) or IGHV status (HR 2·02; 95% CI 1·11-3·69; P = 0·02) individually, but was attenuated when adjusting by both (HR 1·72; 95% CI 0·88-3·38; P = 0·11).These data demonstrate that CD49d-positive CLL patients experience a disease course dominated by lymphadenopathy.
|
28386906 |
2017 |
|
IGHV3OR16-7
|
Carcinogenesis
|
0.010 |
GeneticVariation |
BEFREE |
Our findings show, for the first time, a significant association between biased usage of autoreactive IGHV and somatic mutation of NF-κB regulators in MALT lymphoma, arguing for their cooperation in sustaining chronic B-cell receptor signalling and driving oncogenesis in lymphoma development.
|
28682481 |
2017 |
|
IGHV3OR16-7
|
Familial primary gastric lymphoma
|
0.010 |
GeneticVariation |
BEFREE |
Our findings show, for the first time, a significant association between biased usage of autoreactive IGHV and somatic mutation of NF-κB regulators in MALT lymphoma, arguing for their cooperation in sustaining chronic B-cell receptor signalling and driving oncogenesis in lymphoma development.
|
28682481 |
2017 |
|
IGHV3OR16-7
|
Immunosuppression
|
0.010 |
Biomarker |
BEFREE |
Chronic lymphocytic leukemias (CLLs) with unmutated (U-CLL) or mutated (M-CLL) IGHV have variable features of immunosuppression, possibly influenced by those CLL cells activated to produce interleukin 10 (IL-10).
|
27890932 |
2017 |
|
IGHV3OR16-7
|
Acute lymphocytic leukemia
|
0.010 |
GeneticVariation |
BEFREE |
Similar patterns of IGHV-gene usage to those demonstrated here have been observed in inherited acute lymphoblastic leukaemia.
|
25752595 |
2015 |
|
IGHV3OR16-7
|
Monoclonal Gammopathy of Undetermined Significance
|
0.010 |
GeneticVariation |
BEFREE |
Since MGUS generally precedes MM, these data suggest origins of MGUS and MM with IGHV gene mutational ICV from the same GC B-cell, arising via a distinctive pathway.
|
25929340 |
2015 |
|
IGHV3OR16-7
|
Malformations of Cortical Development, Group II
|
0.010 |
Biomarker |
BEFREE |
Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia.
|
25645933 |
2015 |
|
IGHV3OR16-7
|
anaphylaxis
|
0.010 |
GeneticVariation |
BEFREE |
We therefore investigated IGHV mutations in IgE-associated sequences derived from ten individuals with a history of anaphylactic reactions to bee or wasp venom or peanut allergens.
|
24586993 |
2014 |
|
IGHV3OR16-7
|
Small Lymphocytic Lymphoma
|
0.010 |
GeneticVariation |
BEFREE |
14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma.
|
24729385 |
2014 |
|
IGHV3OR16-7
|
Constitutional Symptom
|
0.010 |
GeneticVariation |
BEFREE |
At the time of presentation, AA patients had lower median hemoglobin levels (12.9 g/dL vs 13.7 g/dL), higher β2 microglobulin levels (2.7 mg/dL vs 2.4 mg/dL), greater frequency of constitutional symptoms (27% vs 10%), unmutated immunoglobulin heavy-chain variable region (IGHV) mutation status (65% vs 47%), ζ-chain-associated protein kinase 70 (ZAP70) expression (58% vs 32%), and deletion of chromosome 17p or chromosome 11q (28% vs 17%; P ≤ 02 for each comparison).
|
24022787 |
2013 |
|
IGHV3OR16-7
|
Waldenstrom Macroglobulinemia
|
0.010 |
GeneticVariation |
BEFREE |
IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas.
|
22944768 |
2013 |
|
IGHV3OR16-7
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker |
BEFREE |
NOTCH1 mutation increased the risk of transformation to diffuse large B-cell lymphoma independently from IGHV, with this being validated in resampling tests of replicability.
|
23295735 |
2013 |
|
IGHV3OR16-7
|
Anemia
|
0.010 |
Biomarker |
BEFREE |
In SMZL, splenomegaly, anaemia and IGHV genes with >98% homology to the germline predicted the need for treatment; older age, anaemia and IGHV unmutated genes (100% homology) predicted shorter survival.
|
22594855 |
2012 |
|
IGHV3OR16-7
|
Acute intermittent porphyria
|
0.010 |
Biomarker |
BEFREE |
However, the rate of unmutated VH fragments in type 1 AIP (17%) was higher than that in obstructive pancreatitis (5.1%) (P= 0.010).
|
22524659 |
2012 |