Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Positional cloning of the gene for multiple endocrine neoplasia-type 1. 9103196

1997
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterised by tumours of the parathyroids, pancreas and anterior pituitary that represents one of the familial cancer syndromes. 9215690

1997
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states. 9215689

1997
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT We examined MEN1 gene mutations in MEN1 and MEN1 related cases in eight unrelated Japanese families. 9832038

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas. 9740255

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT In this study, a total of 84 families and/or isolated patients with either MEN1 or MEN1-related inherited endocrine tumors were screened for MEN1 germ-line mutations, by heteroduplex and sequence analysis of the MEN1 gene-coding region and untranslated exon 1. 9683585

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism. 9709976

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT SSCV analysis proved an effective and sensitive method for the detection of menin mutations providing a reliable genetic screening approach supporting genetic counseling and clinical management of MEN1 family members. 9820618

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Novel MEN1 gene mutations in familial multiple endocrine neoplasia type 1. 9747036

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism. 9709921

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Five novel mutations in the familial multiple endocrine neoplasia type 1 (MEN1) gene. Mutations in brief no. 188. Online. 10660339

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT We analyzed the haplotypes of families with recurrent MEN1 mutations with seven polymorphic markers in the 11q13 region surrounding the MEN1 gene (from D11S1883 to D11S4908). 9671267

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Based on these, we conclude that the loss of function of menin is etiological for familial or sporadic MEN-1, but not for FIHP or most familial pituitary adenoma without MEN-1. 9506756

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Characterization of mutations in patients with multiple endocrine neoplasia type 1. 9463336

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Menin mutations in MEN1 patients. 9709985

1998
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT We identified heterozygous germline mutations of the MEN1 gene in all of 16 Japanese MEN1 families examined, achieving the highest detectability of MEN1 mutations in familial MEN1 among studies that examined more than 10 families. 10576763

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects. 10090472

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT The MEN1 tumor predisposition syndrome is caused by mutations in the MEN1 gene on human chromosome 11q13. 10534569

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Mutation analysis of the MEN1 gene in Belgian patients with multiple endocrine neoplasia type 1 and related diseases. 9888389

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT A new mutation of the MEN1 gene in an italian kindred with multiple endocrine neoplasia type 1. 10229909

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription. 9989505

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Molecular pathology of multiple endocrine neoplasia type I: two novel germline mutations and updated classification of mutations affecting MEN1 gene. 10617276

1999
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. 10664520

2000
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT Based on our clinical experience with MEN 1 patients/families we formulated clinical criteria to identify disease gene carriers among patients with apparently sporadic MEN 1-related tumours. 10849016

2000
Entrez Id: 4221
Gene Symbol: MEN1
MEN1
CUI: C0025267
Disease: Multiple Endocrine Neoplasia Type 1
Multiple Endocrine Neoplasia Type 1 		0.900 GeneticVariation UNIPROT A better understanding of early onset MEN 1 disease is needed to formulate recommendations for early MEN 1 genetic testing. 11134142

2000