×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
CLINVAR
Randomized phase II study of dacomitinib (PF-00299804), an irreversible pan-human epidermal growth factor receptor inhibitor, versus erlotinib in patients with advanced non-small-cell lung cancer.
22753918 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Therefore, in contrast to advanced LADC, EGFR mutation testing may not be necessarily performed upfront in advanced LSQC because not only the mutation rate is low, but also the predictive value is insufficient.
25053390 2014
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Detection of the EGFR mutation in exhaled breath condensate from a heavy smoker with squamous cell carcinoma of the lung .
21684624 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Ten of 215 pure SQCC s (4.7%; 95% CI, 2.3%-8.4%) harbored mutations, including seven with PIK3CA, and each with AKT1, DDR2, and EGFR .
24158231 2014
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
The epidermal growth factor receptor (EGFR ) mutations occur mostly in adenocarcinomas and rarely in squamous cell carcinoma of lung .
17186532 2007
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
This study was focused on EGFR somatic mutations and amplifications in squamous cell lung cancer .
20635059 2010
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Targeting PKCι-PAK1 signaling pathways in EGFR and KRAS mutant adenocarcinoma and lung squamous cell carcinoma .
31660987 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Activation of the BMP-BMPR pathway conferred resistance to EGFR -TKIs in lung squamous cell carcinoma patients with EGFR mutations.
26216950 2015
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
EGFR mutation is associatedwith short PFS and the brain is the most common site of distant metastasis in patients with stage III non- squamous cell lung cancer treated with CCRT.29914238 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
EGFR rs2233947 correlated with lung cancer in males, smokers, and in the squamous cell carcinoma lung cancer subtype (P<0.01).31518089 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
To analyze the distribution of epidermal growth factor receptor (<i>EGFR</i>) mutations; characterize the clinical and imageological features of lung squamous cell carcinoma (LSCC ) in a large population of patients; and assess correlations between clinical and imageological characteristics and clinical outcomes of LSCC patients harboring <i>EGFR</i> mutations.
31695493 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
The aim of this study was to evaluate the status of erlotinib treatment and EGFR mutation in lung SCC patients.
22420950 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
We found EGFR -mutant LUAD showed significantly higher ITHi than KRAS-mutant LUAD/wild-type LUAD (P = 0.03) and numerically higher ITH than LUSC .
30626401 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
The EGFR-TKIs had a modest response for EGFR mutated lung squamous cell carcinoma patients and might be a selective option for those patients.
28881841 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Epidermal growth factor receptor mutations and the clinical outcome in male smokers with squamous cell carcinoma of lung .19543508 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
A subsequent advanced SCC bearing EGFR L858R /T790M mutations occurred 3 years after surgery.
28272214 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
The Q787Q EGFR polymorphism allows stratifying lung squamous cell carcinoma patients and could be an independent prognostic marker, particularly among those in stages I and II.
26999786 2016
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
CLINVAR
MEK inhibitors reverse resistance in epidermal growth factor receptor mutation lung cancer cells with acquired resistance to gefitinib.
23102728 2013
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Significance of epidermal growth factor receptor gene mutations in squamous cell lung carcinoma .
21318227 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Fourteen epidermal growth factor receptor (EGFR )-mutant LSCC patients treated with first-line EGFR-tyrosine kinase inhibitor (TKI) therapy were enrolled for validation dataset.
30643941 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
CLINVAR
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
26619011 2016
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
The administration of afatinib to Sq patients after selecting patients using the EGFR mutation test based on their underlying pulmonary disease and smoking status would likely result in a population with a greater sensitivity to afatinib.
29446042 2018
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
However, the application of TKIs for lung squamous cell carcinoma (SCC), the second largest pathological subtype of NSCLC, remains controversial because available data for the EGFR mutation profile and frequency in SCC patients are limited.
29075127 2017
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Amplification Refractory Mutation System was used to detect the EGFR gene mutation status in the 163 SQCLC specimens.
25886585 2015
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Squamous cell carcinoma of lung
0.500
GeneticVariation
BEFREE
Third-generation tyrosine kinase inhibitor in the treatment of epidermal growth factor receptor mutated squamous cell lung cancer : a tailored therapy approach.
30788361 2019