×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Susceptibility for and clinical manifestations of rheumatoid arthritis are associated with polymorphisms of the TNF-alpha, IL-1beta, and IL-1Ra genes.
11838837 2002
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
We observed an increased frequency of the rare allele IL1RN *3 in RA patients with active disease, not responding to MTX therapy (MTX-NR) (4.5%) vs MTX-R (3.6%) and healthy controls (0.8%).
16886894 2006
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
This meta-analysis demonstrates that the IL-1RN VNTR polymorphism is not related to susceptibility to RA .
20863445 2010
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Several studies have reported a variable number of tandem repeat (VNTR) 86 bp (rs2234663 ) in the intron 2 of IL1RN gene with RA risk.
28342152 2017
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Metaanalyses of the IL-1B-511 and IL-1RN VNTR polymorphisms identified no association between these polymorphisms and RA .
19004046 2009
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
There was no significant difference in IL-1RN genotype and allele distributions between RA and the control groups.
17207379 2007
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Hence, the purpose of this study was to determine the clinical significance of interleukin-1 receptor antagonist (IL-1Ra ) +2018 polymorphism in RA .
27105431 2016
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
These findings suggest that IL-1B +3954 and IL-1RN genetic polymorphisms are associated with a significantly increased risk of RA in this Chinese population.
17867984 2007
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
A meta-analysis was conducted on the associations between the IL-1A, IL-1B, and IL-1 receptor antagonist (IL-1RN ) polymorphisms and RA .
26718437 2015
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
DNA samples from 107 patients with RA and 111 healthy controls were used to study genotypes of the IL-1RA gene by PCR.
16885604 2006
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
However, the carriage rate of IV allele of IL-1Ra was high in the RA patients with low inflammatory activity.
11578018 2001
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
These data indicate that the IL-1RN + 2017 polymorphism is associated with susceptibility to RA .
12028539 2002
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
IL-1 receptor antagonist (IL-1RA ) gene polymorphism in Sjögren's syndrome and rheumatoid arthritis .
9646842 1998
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Sex influences on the penetrance of IL-1beta and IL-1RN genotypes for rheumatoid arthritis in the Chinese population.
17593860 2007
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
This study suggests that IL-1 family gene (IL1F10 and IL1RN ) polymorphisms may play an important role in the susceptibility to developing RA .
20141484 2010
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
GeneticVariation
BEFREE
Our results indicated that IL-1RN VNTR, IL-1β (-511C>T) and IL-10 (-1082 G>A) are associated with susceptibility to RA , and that IL-1RN VNTR, IL-1β (-511C>T) and TNFα (-308 G>A) are associated with severity of RA .
26003199 2015
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
Anakinra, an interleukin-1 receptor antagonist and tocilizumab, an interleukin-6 receptor blocker, are used for the treatment of rheumatoid arthritis .
30859382 2019
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
The increased frequency of IL1RN *2 was confirmed in group B patients with RA (OR 1.44, 95% CI 1.1-1.97, P = 0.01).
16200608 2005
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
In conclusion, our data suggest that IL-1RA gene polymorphism is not responsible for specific clinical characteristics in RA and SLE but that IL-1RN *2 is relevant in the susceptibility to RA , suggesting a protective role of IL-1RN *2 in the pathogenesis of RA .
14872281 2004
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
The anti-interleukin-1 receptor antagonist , anakinra, was approved for the treatment of rheumatoid arthritis (RA ) more than 12 years ago.
29883212 2018
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
Although interleukin-1 receptor antagonist (Anakinra; Amgen Corp.) is approved by the Food and Drug Administration (FDA) for the treatment of rheumatoid arthritis and neonatal-onset multisystem inflammatory disease, little is known about the local use this drug in cutaneous wound healing.
29553981 2018
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
Through the production of IL-1Ra , MSCs reduced migration of DCs to the draining lymph nodes and attenuated generation of inflammatory Th1 and Th17 cells that resulted in alleviation of fulminant hepatitis and rheumatoid arthritis .
31755595 2019
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
The presence of IL-1ra in RA and OA tissues was confirmed by Northern blot analysis for IL-1ra mRNA.(ABSTRACT TRUNCATED AT 250 WORDS)
1458286 1992
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
By immunohistochemistry, cadherin-11 expression was increased in the synovium of mice with CIA and IL-1Ra -deficient mice and in patients with RA .
21798287 2011
×
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
Rheumatoid Arthritis
0.400
Biomarker
BEFREE
Two clinical trails using ex vivo retrovirus mediated delivery of interleukin -1 receptor antagonist gene for rheumatoid arthritis has begun in USA and Germany.
14577650 2003