×
Entrez Id: 9474
Gene Symbol: ATG5
ATG5
Triple Negative Breast Neoplasms
0.020
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5 : autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 10533
Gene Symbol: ATG7
ATG7
Triple Negative Breast Neoplasms
0.020
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7 : autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 9212
Gene Symbol: AURKB
AURKB
Triple Negative Breast Neoplasms
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB : aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 8678
Gene Symbol: BECN1
BECN1
Triple Negative Breast Neoplasms
0.080
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1 : beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 2597
Gene Symbol: GAPDH
GAPDH
Triple Negative Breast Neoplasms
0.010
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH : glyceraldehyde-3-phosphate dehydrogenase ; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2 : erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 8878
Gene Symbol: SQSTM1
SQSTM1
Triple Negative Breast Neoplasms
0.030
Biomarker
BEFREE
<b>Abbreviations:</b> 3-MA: 3-methyladenine; ATG5: autophagy related 5; ATG7: autophagy related 7; AURKA: aurora kinase A; AURKB: aurora kinase B; BECN1: beclin 1; CQ: chloroquine; DMSO: dimethyl sulfoxide; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GFP: green fluorescent protein; ERBB2: erb-b2 receptor tyrosine kinase 2; MAP1LC3B/LC3B: microtubule-associated protein 1 light chain 3 beta; MTOR: mechanistic target of rapamycin kinase; PARP1: poly(ADP-ribose) polymerase 1; PI: propidium iodide; SQSTM1/p62: sequestosome 1 ; TNBC: triple-negative breast cancer .
30773992 2019
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Triple Negative Breast Neoplasms
0.100
AlteredExpression
BEFREE
<b>Background:</b> "Triple-negative breast cancers " (TNBC) comprise a heterogeneous group of about 15% of invasive BCs lacking the expression of estrogen and progesterone receptors (ER, PR) and the expression of HER2 (ERBB2 ) and are therefore no established candidates for targeted treatment options in BC, i.e., endocrine and anti-HER2 therapy.
30087699 2018
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> Triple-negative breast cancer (TNBC ) is a breast cancer that tests negative for estrogen receptor (ER ), progesterone receptors, and human epidermal growth factor receptors 2 (HER2).
31839713 2019
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> Triple-negative breast cancer (TNBC) is a breast cancer that tests negative for estrogen receptor (ER), progesterone receptors, and human epidermal growth factor receptors 2 (HER2 ).
31839713 2019
×
Entrez Id: 5293
Gene Symbol: PIK3CD
PIK3CD
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> The PI3K /AKT/mTOR pathway is an important oncogenic driver in triple-negative breast cancer (TNBC ).
29675095 2018
×
Entrez Id: 5291
Gene Symbol: PIK3CB
PIK3CB
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> The PI3K /AKT/mTOR pathway is an important oncogenic driver in triple-negative breast cancer (TNBC ).
29675095 2018
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> The PI3K /AKT/mTOR pathway is an important oncogenic driver in triple-negative breast cancer (TNBC ).
29675095 2018
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> The PI3K /AKT/mTOR pathway is an important oncogenic driver in triple-negative breast cancer (TNBC ).
29675095 2018
×
Entrez Id: 207
Gene Symbol: AKT1
AKT1
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Background:</b> The PI3K/AKT /mTOR pathway is an important oncogenic driver in triple-negative breast cancer (TNBC ).
29675095 2018
×
Entrez Id: 10134
Gene Symbol: BCAP31
BCAP31
Triple Negative Breast Neoplasms
0.010
Biomarker
BEFREE
<b>Conclusion</b>: These findings reveal the functional role of BCAP31 , an ER-related protein, in EGFR dysregulation and TNBC development.
31588230 2019
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Triple Negative Breast Neoplasms
0.100
GeneticVariation
BEFREE
<b>Conclusion</b>: These findings reveal the functional role of BCAP31, an ER-related protein, in EGFR dysregulation and TNBC development.
31588230 2019
×
Entrez Id: 9332
Gene Symbol: CD163
CD163
Triple Negative Breast Neoplasms
0.030
Biomarker
BEFREE
<b>Conclusion:</b> Cancer-associated fibroblasts were associated with infiltration of CD163 -positive macrophages and lymphatic metastasis, and may be potential prognostic predictors of TNBC .
30588247 2018
×
Entrez Id: 4233
Gene Symbol: MET
MET
Triple Negative Breast Neoplasms
0.100
GeneticVariation
BEFREE
<b>Conclusion:</b> Our case-control study suggests that MET T1010I seems to be a risk factor for TNBC in the Caucasian Greek population, in contrast with MET rs40239 , where no correlation was found.
31213837 2019
×
Entrez Id: 5879
Gene Symbol: RAC1
RAC1
Triple Negative Breast Neoplasms
0.060
Biomarker
BEFREE
<b>Conclusion:</b> Our findings suggest that TUFT1/Rac1 /β-catenin pathway may provide a potential target for more effective treatment of TNBC .
31338333 2019
×
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Conclusion:</b> Our findings suggest that TUFT1/Rac1/β-catenin pathway may provide a potential target for more effective treatment of TNBC .
31338333 2019
×
Entrez Id: 207
Gene Symbol: AKT1
AKT1
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Conclusion:</b> Our results demonstrated that targeting MAT2B could suppress cell growth and migration and induce apoptosis by inhibiting the AKT and ERK pathways in TNBC .
31354356 2019
×
Entrez Id: 5594
Gene Symbol: MAPK1
MAPK1
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Conclusion:</b> Our results demonstrated that targeting MAT2B could suppress cell growth and migration and induce apoptosis by inhibiting the AKT and ERK pathways in TNBC .
31354356 2019
×
Entrez Id: 2048
Gene Symbol: EPHB2
EPHB2
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Conclusion:</b> Our results demonstrated that targeting MAT2B could suppress cell growth and migration and induce apoptosis by inhibiting the AKT and ERK pathways in TNBC .
31354356 2019
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Triple Negative Breast Neoplasms
0.100
Biomarker
BEFREE
<b>Conclusion:</b> We demonstrated that DFO could upregulate expression of TfR1 and DMT1 , which enhanced iron uptake via activating IL-6/PI3K /AKT signaling pathway in aggressive TNBC s.
31213851 2019