×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
25980754 2015
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry.
22949379 2013
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the constitutional mismatch repair deficiency consortium.
24440087 2014
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer.
20487569 2010
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
20028993 2010
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Germline MSH6 mutations are more prevalent in endometrial cancer patient cohorts than hereditary non polyposis colorectal cancer cohorts.
18269114 2008
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population.
27601186 2016
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer.
9929971 1999
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Germ-line msh6 mutations in colorectal cancer families.
10537275 1999
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.
27443514 2016
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.
15236168 2004
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
25980754 2015
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.
16283884 2005
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
18566915 2009
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
22006311 2011
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.
24763289 2014
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts.
27273229 2017
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Familial endometrial cancer in female carriers of MSH6 germline mutations.
10508506 1999
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.
24362816 2014
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
GeneticVariation
CLINVAR
Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome.
8063241 1994
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
The gastrointestinal manifestation of constitutional mismatch repair deficiency syndrome: from a single adenoma to polyposis-like phenotype and early onset cancer.
25307252 2015
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer.
23047549 2012
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.
25559809 2015
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
18301448 2008
×
Entrez Id: 80204
Gene Symbol: FBXO11
FBXO11
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.100
CausalMutation
CLINVAR
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers.
20587412 2010