×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
GeneticVariation
UNIPROT
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
GenomicAlterations
CGI
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
C-Met as a prognostic marker in gastric cancer : a systematic review and meta-analysis.
24223894
2013
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
MET rs40239 may serve as a prognostic biomarker in locoregional gastric cancer .
25203738
2014
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
MET -positive GC s had a very poor prognosis, with a median survival of 5.4 months and a hazard ratio of 2.126.
26033401
2016
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
c-Met targeting in advanced gastric cancer : An open challenge.
26049023
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
MET amplification has been clinically credentialed as a therapeutic target in gastric cancer , but the molecular mechanisms underlying sensitivity and resistance to MET inhibitors are still not well understood.
28881678
2017
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
MET amplification and Met overexpression were positively correlated in GC .
29790169
2018
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
A multivariate analysis suggested that MET positivity may still be prognostic for worse median overall survival in gastric cancer ; therefore, it is important to continue investigation into the optimal approach to inhibit MET signaling in gastric cancer .
27401892
2016
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
A novel tetravalent bispecific antibody targeting programmed death 1 and tyrosine-protein kinase Met for treatment of gastric cancer .
30511201
2019
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Also, the prognostic role of MET indicates that anti-MET therapy is a very promising modality in adjuvant treatment for gastric cancer .
22644302
2012
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
GeneticVariation
BEFREE
Approximately 10 - 20% of gastric cancer presented an increased MET gene copy numbers; inappropriate activation of MET promotes cellular proliferation, cell motility, invasiveness and angiogenesis and is associated with more aggressive phenotype and with a lower survival.
25881479
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Candidate tumor suppressor genes at FRA7G are coamplified with MET and do not suppress malignancy in a gastric cancer .
12620387
2003
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Comprehensive genomic profiling of GC identifies clinically relevant GAs that suggest benefit from targeted therapy including MET -amplified GC and ERBB2 base substitutions.
25882375
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Crizotinib may induce clinically relevant anticancer effects in MET-overexpressed or MET -amplified gastric cancer patients.
26404902
2016
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
CTD_human
Crizotinib thus shows a marked antitumor action both in vitro and in vivo specifically in gastric cancer cells positive for MET amplification.
22729845
2012
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Depletion of FOXM1 via MET Targeting Underlies Establishment of a DNA Damage-Induced Senescence Program in Gastric Cancer .
27185371
2016
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Exposure-response analysis of rilotumumab in gastric cancer : the role of tumour MET expression.
25584489
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Expression of gastrin and c-met protein was associated (P<0.01), but no significant difference was found on the changes of gastrin, c-met and c-erbB2 expression in gastric cancer with tumor stage, grade of differentiation or tumor type.
14719064
2004
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
AlteredExpression
BEFREE
Finally, we observed an inverse correlation between the expression of miR-144 and MET mRNA in GC metastatic tissues.
25927670
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Four c-MET inhibitors were tested to elucidate the dependency on MET pathway in the 49 GC cell lines.
29435981
2018
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Furthermore, the profile of the gastric cancer samples observed that sf-RON was frequently upregulated in MET -positive gastric cancer .
26528757
2015
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Impact of MET amplification on gastric cancer : possible roles as a novel prognostic marker and a potential therapeutic target.
21424128
2011
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
Importance of the type I insulin-like growth factor receptor in HER2, FGFR2 and MET -unamplified gastric cancer with and without Ras pathway activation.
27437872
2016
×
Entrez Id:
4233
Gene Symbol:
MET
MET
Malignant neoplasm of stomach
0.700
Biomarker
BEFREE
In 123 cases with primary and corresponding local recurrent/distant metastatic GC , 3 (2.4%) showed MET positivity in which 2 (66.7%) were discordant (positive conversion).
28968267
2018