×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
CausalMutation
CGI
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Notch1 inhibition alters the CD44hi/CD24lo population and reduces the formation of brain metastases from breast cancer .21665937 2011
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Notch-1 and Notch-4 are potent breast oncogenes that are overexpressed in triple-negative and other subtypes of breast cancer .21679465 2011
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Notch1 can also induce the invasion of breast cancer cells.21785827 2011
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation.25263445 2015
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Notch1 silencing reversed the spontaneous EMT process and inhibited the migration and invasion of breast cancer cells and the growth of xenograft breast cancers.25645291 2015
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Notch-1 inhibits p53 activity in cervical and breast cancer cells.26033683 2015
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Notch1 and Notch4 have been reported as prognostic markers in human breast cancer .28108315 2017
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
PosttranslationalModification
BEFREE
A study of the role of Notch1 and JAG1 gene methylation in development of breast cancer .
26971121 2016
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Aberrant expression of Jagged1 and Notch1 are associated with poor outcome in breast cancer .
17984306 2007
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Additionally, GASC1 demethylase activity regulates the expression of genes critical for stem cell self-renewal, including NOTCH1 , and may be linked to the stem cell phenotypes in breast cancer .
19784073 2009
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Analysis of Pearson's correlation coefficient indicated that Notch-1 and survivin co-segregated in basal breast cancer .
19025652 2008
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Blockade of NF-κB signaling suppressed the effects of visfatin on Notch1 upregulation and breast cancer cell proliferation.
24970818 2014
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
BRD4-selective knockdown suppressed Notch1 activity and impeded breast cancer migration and invasion.
27651315 2016
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Compared with MCF-7 monolayer culture cells, mammosphere cells showed significantly (P<0.01) enhanced expression of Wnt1 [fold-change (FC), 2.25], Notch1 (FC, 2.45), β-catenin (FC, 1.72), CXCR4 (FC, 4.68), SOX2 (FC, 4.25) and ALDH3A1 (FC, 5.38).
21573501 2011
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Consistent with this mechanistic link, Notch1 and Myc expression is positively correlated by immunostaining in 38% of examined human breast carcinomas .
16751266 2006
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer .
31527799 2020
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor.
18469855 2008
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Firstly, the levels of Notch 1 were determined by western blot analysis in breast cancer cell lines, and the results revealed that the expression levels of Notch 1 were markedly higher in MDA‑MB‑231 and MCF‑7 cells, and lower in MCF‑10A cells, compared with human mammary epithelial cells.
29207146 2018
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
GeneticVariation
BEFREE
Furthermore, given the inconsistent associations between the rs3124591 variant and Notch1 expression in IDC and DCIS, this variant may affect breast cancer risk through mechanisms in the latter stage other than alterations in Notch1 protein expression.
25120811 2014
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
Furthermore, modulation of KRT19-mediated regulation of NUMB and NOTCH1 expression led to the repression of the cancer stem cell properties of breast cancer patient-derived CD133<sup>high</sup>/CXCR4<sup>high</sup>/ALDH1<sup>high</sup> cancer stem-like cells (CSLCs), which showed very low KRT19 and high NOTCH1 expression.
27345400 2017
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway in Murine Mammary Carcinoma .
30764900 2019
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
Biomarker
BEFREE
Here, we identify an unrecognized EZH2/NOTCH1 axis that controls breast TICs in TN breast carcinomas .
24516139 2014
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
High expression of Notch-1 and its ligand Jagged-1 correlates with poor prognosis in breast cancer .
26945854 2016
×
Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
Breast Carcinoma
0.600
AlteredExpression
BEFREE
High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival.
16166334 2005