×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
25157968 2014
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
One Case of a BRCA1 Germ Line Mutation Ovarian Carcinoma Patient Based on Abnormal Immunohistochemistry Finding.
25366075 2014
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Activating ESR1 mutations in hormone-resistant metastatic breast cancer.
24185510 2013
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
PIK3CA and AKT1 mutations have distinct effects on sensitivity to targeted pathway inhibitors in an isogenic luminal breast cancer model system.
23888070 2013
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
23220880 2013
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
PIK3CA mutation H1047R is associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials.
23066039 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
We conducted a comprehensive genetic analysis of two independent cohorts of metastatic ER-positive breast tumors and identified mutations in ESR1 affecting the ligand-binding domain (LBD) in 14 of 80 cases.
24185512 2013
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Activating HER2 mutations in HER2 gene amplification negative breast cancer.
23220880 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
We conducted a comprehensive genetic analysis of two independent cohorts of metastatic ER-positive breast tumors and identified mutations in ESR1 affecting the ligand-binding domain (LBD) in 14 of 80 cases.
24185512 2013
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Activating ESR1 mutations in hormone-resistant metastatic breast cancer.
24185510 2013
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer.
22798144 2012
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors.
22162589 2012
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Functional differences among BRCA1 missense mutations in the control of centrosome duplication.
21725363 2012
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Phosphatidylinositide-3-kinase inhibitors: addressing questions of isoform selectivity and pharmacodynamic/predictive biomarkers in early clinical trials.
22162582 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
22419737 2012
×
Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Differential sensitivity of ERBB2 kinase domain mutations towards lapatinib.
22046346 2011
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
The selective class I PI3K inhibitor CH5132799 targets human cancers harboring oncogenic PIK3CA mutations.
21558396 2011
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
CHEK2 contribution to hereditary breast cancer in non-BRCA families.
22114986 2011
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Mammary Neoplasms
0.500
GeneticVariation
CLINVAR
Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.
20516115 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058 2010
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models.
20453058 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
The PI3K pathway as drug target in human cancer.
20085938 2010
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
18571837 2008
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974 2008
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Mammary Neoplasms
0.500
CausalMutation
CLINVAR
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
18676830 2008