Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker CTD_human This study evaluated whether genetically decreased HO-1 levels affected susceptibility to liver IRI. 16982915

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker CTD_human Cobalt protoporphyrin (CoPP) was administered IP at 10 or 20mg/kg 24h before IRI, to induce HO-1 upregulation.Control animals received vehicle alone. 17660127

2007
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Biomarker CTD_human Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. 25780291

2015
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Therapeutic CTD_human Resveratrol mitigates rat retinal ischemic injury: the roles of matrix metalloproteinase-9, inducible nitric oxide, and heme oxygenase-1. 23075401

2013
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.510 Therapeutic CTD_human This study evaluated whether genetically decreased HO-1 levels affected susceptibility to liver IRI. 16982915

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.510 Biomarker CTD_human Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE. 20971094

2011
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats. 19804535

2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. 18375438

2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Effects of losartan, HO-1 inducers or HO-1 inhibitors on erectile signaling in diabetic rats. 19804535

2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. 18375438

2008
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Therapeutic CTD_human Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. 16123366

2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.500 Biomarker CTD_human Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. 16959961

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Heme oxygenase-1 regulates the major route involved in formation of immune hepatic fibrosis in rats. 21163135

2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. 16610050

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats. 16610050

2006
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. 16025519

2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats. 16025519

2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Heme oxygenase-1 regulates the major route involved in formation of immune hepatic fibrosis in rats. 21163135

2010
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Therapeutic CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Therapeutic CTD_human Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. 16319139

2005
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury 		0.500 Therapeutic CTD_human Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1. 21048024

2011
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.500 Therapeutic CTD_human Urinary excretion of bilirubin oxidative metabolites in arsenite-treated mice. 22688006

2012