Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6511
Gene Symbol: SLC1A6
SLC1A6
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET We also detected decreased EAAT3 transcript expression in schizophrenia and decreased EAAT4 transcript expression in major depressive disorder. 11850151

2002

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker PSYGENET Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression. 11904129

2002

Entrez Id: 1621
Gene Symbol: DBH
DBH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker PSYGENET A polymorphism in the dopamine beta-hydroxylase gene is associated with "paranoid ideation" in patients with major depression. 11904130

2002

Entrez Id: 9968
Gene Symbol: MED12
MED12
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET Consistent with our prior findings, HOPA polymorphisms were associated with an increased risk for major depression. 12216017

2002

Entrez Id: 52
Gene Symbol: ACP1
ACP1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET In a recent study we found that nonA/nonA homozygosity at the locus codifying for the low molecular weight protein tyrosine phosphatase (ACP1) was associated with increased rates of major depression in males (P<0.00003), suggesting that the ACP1*A single nucleotide polymorphism (SNP) may be an important marker for psychopathology. 12231445

2002

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.300 Biomarker CTD_human Emotional distress during interferon-alpha-2B and ribavirin treatment of chronic hepatitis C. 12297606

2002

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. 12438692

2002

Entrez Id: 3304
Gene Symbol: HSPA1B
HSPA1B
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET We suggest that the 162-base deletion in the 5'-flanking region of the HSP70-1 gene mRNA is not associated with major depression. 12763290

2003

Entrez Id: 3303
Gene Symbol: HSPA1A
HSPA1A
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET We suggest that the 162-base deletion in the 5'-flanking region of the HSP70-1 gene mRNA is not associated with major depression. 12763290

2003

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347

2003

Entrez Id: 1393
Gene Symbol: CRHBP
CRHBP
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression. 14573312

2003

Entrez Id: 1559
Gene Symbol: CYP2C9
CYP2C9
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker PSYGENET The results suggest that CYP2C9 genetic polymorphism may be related to a major depressive disorder due to an alteration in endogenous metabolism, although a linkage between CYP2C9 and some other gene related to depression cannot be ruled out. 14583800

2003

Entrez Id: 5806
Gene Symbol: PTX3
PTX3
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET Differential expression of pentraxin 3 in fibroblasts from patients with major depression. 14603263

2004

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.500 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 6616
Gene Symbol: SNAP25
SNAP25
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.320 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 1816
Gene Symbol: DRD5
DRD5
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 1742
Gene Symbol: DLG4
DLG4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.320 Biomarker PSYGENET In particular, we found decreased NF-L, PSD95, and SAP102 transcripts in bipolar disorder, and decreased SAP102 levels in major depression. 15054476

2004

Entrez Id: 1741
Gene Symbol: DLG3
DLG3
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.320 Biomarker PSYGENET In particular, we found decreased NF-L, PSD95, and SAP102 transcripts in bipolar disorder, and decreased SAP102 levels in major depression. 15054476

2004

Entrez Id: 4747
Gene Symbol: NEFL
NEFL
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET In particular, we found decreased NF-L, PSD95, and SAP102 transcripts in bipolar disorder, and decreased SAP102 levels in major depression. 15054476

2004

Entrez Id: 2182
Gene Symbol: ACSL4
ACSL4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.300 Biomarker CTD_human Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. 15108178

2004

Entrez Id: 4074
Gene Symbol: M6PR
M6PR
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression. 15167696

2004

Entrez Id: 84062
Gene Symbol: DTNBP1
DTNBP1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.340 Biomarker PSYGENET In conclusion, our results suggest that SNPs in the dysbindin gene are unlikely to play a major role in the pathophysiology of major depression or are in linkage disequilibrium (LD) with a neighboring mutation or gene. 15274041

2004

Entrez Id: 6347
Gene Symbol: CCL2
CCL2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.310 Biomarker PSYGENET Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population. 15296827

2004

Entrez Id: 3351
Gene Symbol: HTR1B
HTR1B
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.330 Biomarker PSYGENET Association study of serotonin 1B receptor (A-161T) genetic polymorphism and suicidal behaviors and response to fluoxetine in major depressive disorder. 15365222

2004