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rs4680
|
|
Cockayne Syndrome, Type I
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA.
|
31142902 |
2020 |
|
rs4680
|
|
Autistic behavior
|
|
0.010 |
GeneticVariation
|
BEFREE |
Within autistic subjects, Val158Met rs4680 carriers were significantly distributed (71.2% P = 0.014) accompanied with abnormal dopamine, abnormal Electroencephalogram (EEG) and increasing the severity of autistic behaviour.
|
31586564 |
2020 |
|
rs4680
|
|
Rest pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Individuals with the COMT rs4680 minor allele reported lowered pain at rest after TENS (β = -42.30; p = .001), with a higher magnitude of pain reduction (28 unit difference) in the low-frequency TENS group compared to the high-frequency TENS group (β = 28.37; p = .0004).
|
31661578 |
2020 |
|
rs4680
|
|
Cockayne Syndrome, Type I
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA.
|
31142902 |
2020 |
|
rs4680
|
|
Hyperalgesia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Effect of catechol-O-methyltransferase (rs4680) single-nucleotide polymorphism on opioid-induced hyperalgesia in adults with chronic pain.
|
31041874 |
2020 |
|
rs4680
|
|
Sleep Apnea, Central
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA.
|
31142902 |
2020 |
|
rs4680
|
|
Sleep Apnea, Central
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study aims to examine <i>COMT</i> Val158Met (rs4680) and <i>BDNF</i> Val66Met (rs6265) polymorphisms in CSA.
|
31142902 |
2020 |
|
rs4680
|
|
Sensory neuropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Catechol-O-methyltransferase polymorphism Val158Met is associated with distal neuropathic pain in HIV-associated sensory neuropathy.
|
31021849 |
2019 |
|
rs4680
|
|
Frequent episodic tension-type headache
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aims of this study were: (1) to investigate the association between the rs4680 Val158Met polymorphism in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH); and (2) to analyze the association between the rs4680 Val158Met polymorphism with clinical, psychological, or psychophysical variables.
|
30614828 |
2019 |
|
rs4680
|
|
Transformed migraine
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Val158Met rs4680 polymorphism does not appear to be involved in predisposition to suffer from migraine; however, this genetic factor may be involved in the phenotypic expression of chronic migraine, as anxiety, depression, and widespread pressure pain sensitivity were greater in those women with chronic, but not episodic, migraine with the Met/Met genotype.
|
30481348 |
2019 |
|
rs4680
|
|
Cannabis Abuse
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients were assessed for neurocognitive measures with a broad battery, genotyped for COMT Val158Met polymorphism from peripheral blood sample, and evaluated with a semi-structured interview in order to establish the history of cannabis abuse.
|
30790675 |
2019 |
|
rs4680
|
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
Five single nucleotide polymorphisms (SNPs) (rs4532 in DRD1, rs2283265 in DRD2, rs6280 in DRD3, rs1800497 in ANKK1, and rs4680 in COMT) and a variable number of tandem repeats (VNTRs) in DAT1 in 295 male patients with AUD were genotyped.
|
31559529 |
2019 |
|
rs4680
|
|
Ablepharon
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neurotypical (N = 91) adults were genotyped for the COMT Val158Met polymorphism, completed the Schizotypal Personality Questionnaire (SPQ), and had eyes open resting-state EEG recorded for 4 min.
|
30084963 |
2019 |
|
rs4680
|
|
Leukemia, T-Cell
|
|
0.010 |
GeneticVariation
|
BEFREE |
We used polymerase chain reaction to genotype the rs4680 (Val158Met) and rs4633 (His62His) variants in the catechol-O-methyltransferase gene and rs2369049 (A > G) and rs7158782 (A > G) variants in the T-cell leukemia/lymphoma 1 A gene.
|
29912452 |
2019 |
|
rs4680
|
|
Arthralgia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Specific genetic variations at loci rs4680 and rs2369049 are associated with response to acupuncture-type intervention for management of arthralgia.
|
29912452 |
2019 |
|
rs4680
|
|
Psoriasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study is to find the associations between SNP in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis.
|
30840133 |
2019 |
|
rs4680
|
|
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
Early-Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met Genotypes.
|
31150143 |
2019 |
|
rs4680
|
|
Verbal hallucinations
|
|
0.010 |
GeneticVariation
|
BEFREE |
COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals-symptom relief accompanied by worrisome volume reductions.
|
30712251 |
2019 |
|
rs4680
|
|
Tension Headache
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Val158Met polymorphism (rs4680) does not appear to be involved in predisposition to tension-type headache; however, this genetic factor may be involved in the pathogenesis expression of CTTH, as greater pressure pain sensitivity and higher depressive levels were found in CTTH carrying the Met/Met genotype.
|
30614828 |
2019 |
|
rs4680
|
|
Episodic tension-type headache
|
|
0.010 |
GeneticVariation
|
BEFREE |
Catechol-O-Methyltransferase (COMT) rs4680 Val158Met Polymorphism is Associated With Widespread Pressure Pain Sensitivity and Depression in Women With Chronic, but not Episodic, Tension-Type Headache.
|
30614828 |
2019 |
|
rs4680
|
|
Alexithymia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The findings suggest that the 5-HTTLPR and COMT Val158Met polymorphisms are not associated with alexithymia.
|
30707988 |
2019 |
|
rs4680
|
|
Hypoalgesia
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this study, we expanded on previous findings related to the 3 SNPs in the opioid receptor mu subunit (OPRM1 rs1799971), catechol-O-methyltransferase (COMT rs4680), and fatty acid amide hydrolase (FAAH rs324420) genes associated with placebo hypoalgesia and tested the effect of a 3-way interaction on placebo hypoalgesia.
|
31335650 |
2019 |
|
rs4680
|
|
opioid use
|
|
0.010 |
GeneticVariation
|
BEFREE |
Associations of catechol-O-methyltransferase (rs4680) single nucleotide polymorphisms with opioid use and dose among adults with chronic pain.
|
30211780 |
2019 |
|
rs4680
|
|
Affective Symptoms
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, there has been no study investigating whether a functional four-SNP (rs6269-rs4633-rs4818-rs4680) haplotype is associated with affective symptoms over the life course.
|
29331705 |
2018 |
|
rs4680
|
|
Algophobia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Influence of catechol-O-methyltransferase Val158Met on fear of pain and placebo analgesia.
|
28968343 |
2018 |