|
rs1056744559
|
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
Of the screened polymorphisms, TT genotype of the missense variant TLR5 (rs5744174) (NM_003268.5:c.1846T>C (p.Phe616Leu) is significantly more frequent in the control group than CHB patients (P<0.001), presence of TT genotype of the upstream variant TLR9 (rs5743836) (NM_017442.3:c.-1237T>C) is more frequent in CHB group (P=0.043).
|
29276096 |
2018 |
|
rs1057317
|
|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The regulatory association between rs1057317 polymorphism in TLR4 3'-UTR led to an inhibitory effect on the expression of TLR4 by miR-34a, which may explain the observed association between the polymorphism and the susceptibility to OP.
|
30989725 |
2019 |
|
rs1057317
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data of this study suggested that the rs1057317 polymorphism in the miR-34a binding site of TLR4 may predict the risk of HP-induced GC.
|
30242897 |
2018 |
|
rs1057317
|
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
|
0.010 |
GeneticVariation
|
BEFREE |
It was found that, in HP-positive patient, the AA genotype of the rs1057317 polymorphism was closely associated with the risk of GC (95% confidence interval, 1.12 to 2.70; odds ratio, 1.74; P = 0.0129).
|
30242897 |
2018 |
|
rs1057317
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data of this study suggested that the rs1057317 polymorphism in the miR-34a binding site of TLR4 may predict the risk of HP-induced GC.
|
30242897 |
2018 |
|
rs1057317
|
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the expression of TLR4 was detected in the peripheral blood mononucleated cell of hepatocellular carcinoma (HCC) patients, suggesting that mRNA and protein levels of TLR4 might be associated with SNP rs1057317.
|
25179842 |
2014 |
|
rs10759932
|
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of rs10759932 and rs2737190 in TLR4 are significantly related to both COPD and PTB but with inverse effects.
|
31640653 |
2019 |
|
rs10759932
|
|
Precancerous Conditions
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR4 rs10759932, but not TLR2 rs3804099 and rs3804100, was associated with risk of premalignant and/or malignant and H. pylori susceptibility.
|
30301709 |
2019 |
|
rs10759932
|
|
Ischemic stroke
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, the rs10759932 polymorphism may affect inflammatory response in IS patients.
|
29075930 |
2018 |
|
rs10759932
|
|
Henoch-Schoenlein Purpura
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addition, we observed that a significantly decreased frequency of the haplotype GTC (rs1927914-rs10759932-rs1927907) in HSP patients compared with controls (OR = 0.56; p = 0.028).
|
28905155 |
2017 |
|
rs10759932
|
|
Psoriasis vulgaris
|
|
0.010 |
GeneticVariation
|
BEFREE |
The comparison of allele distributions revealed that only one SNP (rs3804099) of 6 common SNPs(rs10759932, rs11536889, rs11536891, rs1927914, rs3804099, rs4696480) was significant associated with the risk of PsV (P<0.01; FDR p-Value).
|
27155792 |
2016 |
|
rs10759932
|
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs10759932
|
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
In contrast, the rs2770150 is associated with colon cancer in women aged over 50 years and is closely linked with the decreased levels of female sex hormones during the post-menopausal period (OR = 0.188, CI: 0.074-0.48, P = <0.00084). rs10759932 and rs4986790 appear to have any association with colon cancer.
|
26771524 |
2016 |
|
rs10759932
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation
|
BEFREE |
In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P = 0.002 for rs10759932, odds ratio 1.136, P = 0.009 for rs1927911, odds ratio 0.882, P = 0.024 for rs11536889).
|
25104099 |
2015 |
|
rs10759932
|
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.
|
26167073 |
2015 |
|
rs10759932
|
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.
|
26167073 |
2015 |
|
rs10759932
|
|
precancerous lesions
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR4 rs10759932 TC and C carriers were associated with a lower risk in developing precancerous lesions in the stomach in a Chinese Han population.
|
24269697 |
2014 |
|
rs10759932
|
|
Bacterial Vaginosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjustment for race, smoking, and bacterial vaginosis, carriage of these alleles was associated with chorionic plate inflammation (maternal rs1554973: odds ratio [OR] 5.2, 95% confidence interval, 3.2-6.4, P = .006; fetal rs10759932: OR 4.95, 95% confidence interval, 3.0-5.6, P = .005).
|
18928988 |
2008 |
|
rs10759932
|
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two single-nucleotide polymorphisms showed nominally statistically significant associations with prostate cancer risk, with the strongest (rs10759932) associated with a 4-fold increased risk of disease (P = 0.006).
|
17301271 |
2007 |
|
rs10759932
|
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation
|
BEFREE |
Two single-nucleotide polymorphisms showed nominally statistically significant associations with prostate cancer risk, with the strongest (rs10759932) associated with a 4-fold increased risk of disease (P = 0.006).
|
17301271 |
2007 |
|
rs11536878
|
|
Rheumatoid Arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There were no associations of TLR4 rs11536878 and rs4986790 SNPs with RA disease activity progression.
|
25573402 |
2015 |
|
rs11536878
|
|
Gastritis, Atrophic
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs11536878 polymorphism was not associated with GC or AG.
|
25084512 |
2014 |
|
rs11536878
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs11536878 polymorphism was not associated with GC or AG.
|
25084512 |
2014 |
|
rs11536878
|
|
Malignant neoplasm of stomach
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs11536878 polymorphism was not associated with GC or AG.
|
25084512 |
2014 |
|
rs11536878
|
|
Infection caused by Helicobacter pylori
|
|
0.010 |
GeneticVariation
|
BEFREE |
Using a case-control study, we analyzed the genotypic distribution of TLR4 rs10983755 (-2081G/A) and rs11536878 in a Chinese population and investigated the effect of their interactions with Helicobacter pylori infection on susceptibility to gastric cancer (GC) and atrophic gastritis (AG).
|
25084512 |
2014 |