|
rs7624041
|
|
Stomach Carcinoma
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Meta-analysis of genome-wide association studies and functional assays decipher susceptibility genes for gastric cancer in Chinese populations.
|
31383772 |
2020 |
|
rs1108143
|
|
Stomach Carcinoma
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Identification of new susceptibility loci for gastric non-cardia adenocarcinoma: pooled results from two Chinese genome-wide association studies.
|
26701879 |
2017 |
|
rs1917799
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 rs1917799 polymorphism was observed for the risk of gastric cancer (P interaction = 0.026); and interaction effects of pri-let-7a-1 rs10739971 polymorphism with PGC rs6458238 polymorphism (P interaction = 0.012) and PGC rs9471643 polymorphism (P interaction = 0.039) were observed for the risk of atrophic gastritis.
|
24586594 |
2014 |
|
rs1917799
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
ERCC6 rs1917799 GG genotype might be associated with increased GC risk in Chinese, especially in males.
|
24289633 |
2013 |
|
rs1917799
|
|
Stomach Carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
ERCC6 rs1917799 also showed a significant interaction with ERCC8 rs158916 to reduce gastric cancer risk.
|
28562347 |
2017 |
|
rs889312
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Cox regression analysis, log-rank test and Kaplan-Meier method were used to explore the link between MAP3K1 rs889312 variant and overall survival (OS) of GC.
|
31686841 |
2019 |
|
rs889312
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Considering steroid hormone-mediated signaling pathways have an important role in the progression of gastric cancer, we hypothesized that MAP3K1 rs889312 may be associated with survival outcomes in gastric cancer.
|
24759887 |
2014 |
|
rs7560488
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation.
|
27789275 |
2016 |
|
rs7560488
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that the genetic variations in the DNMT3A1 promoter contribute to the susceptibility to GC and also provide an insight that tagSNP rs7560488 T>C may be a promising biomarker for predicting GC genetic susceptibility and a valuable information in GC pathogenesis.
|
24667323 |
2014 |
|
rs4460629
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Recently, a genome-wide association study of gastric cancer (GC) reported the significant association of seven genetic variants (rs4072037 and rs4460629 on 1q22; rs753724, rs11187842, rs3765524, rs2274223, and rs3781264 on 10q23) with GC in a Chinese population.
|
22740136 |
2012 |
|
rs4460629
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model.
|
22938415 |
2012 |
|
rs36012910
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs36012910 allele G was associated with an increased risk of G</span>C compared to the rs36012910 allele A.
|
23053986 |
2012 |
|
rs36012910
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Lastly, a systematic review on 7 studies for 17 SNPs suggested that rs36012910, rs7560488 and rs6087990 might have a potential effect on GC initiation.
|
27789275 |
2016 |
|
rs12155758
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Although rs12155758 and rs9297976 were also found associated with GC, this association appeared to be due to linkage disequilibrium with rs2294008.
|
21681742 |
2012 |
|
rs12155758
|
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
SNP rs12155758 was not associated with risk of gastric preneoplastic lesions, but we confirmed its association with higher GC risk (OR 1.95; 95% CI 1.29-2.97 for dominant model).
|
24023815 |
2013 |
|
rs9981660
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Moreover, we found that TFF2 rs3814896 AG+GG genotypes in people aged ≤ 50 years and TFF3 rs9981660 AG+AA genotypes in younger males with diffuse-type GC were associated with higher levels of TFF2 and TFF3 mRNA respectively.
|
23933418 |
2013 |
|
rs9564966
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our findings suggested that the rs9564966 G > A polymorphism may be a potential biomarker to predict the survival of Chinese patients with GC.
|
30537204 |
2019 |
|
rs9502893
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, a shared susceptibility locus rs9502893 was found to have significant protective effect against CRC (p = 0.010; OR = 0.80) and GC (p = 0.0003; OR = 0.74).
|
26383524 |
2016 |
|
rs917997
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among 11 candidate single nucleotide polymorphisms (SNPs), subjects carrying IL-18RAP rs917997 AA genotype were associated with risk of GC [adjusted odds ratio (OR) = 1.83, 95 % confidence interval (CI) 1.14-2.92] or chronic atrophic gastritis (CAG; OR = 1.55, 95 % CI 1.07-2.24).
|
26358252 |
2016 |
|
rs4912913
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Finally, we made a joint effect analysis of rs12521436, rs33388 and rs4912913 on risk of gastric cancer (<i>P<sub>Trend</sub></i> =2.83×10<sup>-5</sup>).
|
29285253 |
2017 |
|
rs4733616
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study suggests that the SNP rs4733616 is associated with susceptibility to poorly differentiated gastric cancer in Venezuelans.
|
25939847 |
2015 |
|
rs4145643
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
CDK1 rs4145643, FAS rs6586161, and FAS rs1468063 in the AKT signaling pathway presented significant genetic effects on gastric cancer (OR = 0.81 (95% CI: 0.66-0.99) for CDK1 rs4145643; OR = 1.27 (95% CI: 1.03-1.58) for FAS rs6586161; OR = 1.29 (95% CI: 1.03-1.56) for FAS rs1468063; Cochran Q statistics > 0.10).
|
23042672 |
2012 |
|
rs398652
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Interestingly, RTL-related rs621559 and rs398652 genetic variants are significantly associated with GC risk.
|
27797826 |
2017 |
|
rs2689154
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively).
|
28404937 |
2017 |
|
rs26160
|
|
Stomach Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
However, none of the four polymorphisms or their haplotypes achieved significant differences in their distributions between gastric cancer cases and controls, and interestingly, in the subgroup analysis of gastric cancer, we found that CA genotype of rs26160 and CG genotype of rs17690554 were associated with the risk of diffuse gastric cancer, compared with their wild genotypes (OR = 2.98, 95 % CI: 1.60-5.53; OR = 2.10, 95 % CI: 1.14-3.85, respectively, P < 0.05).
|
22535324 |
2012 |