|
rs17401966
|
|
Liver carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASDB |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
Liver carcinoma
|
A |
0.900 |
GeneticVariation
|
GWASCAT |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
We identified one intronic SNP (rs17401966) in KIF1B on chromosome 1p36.22 that was highly associated with HBV-related HCC and confirmed this association in five additional independent samples, consisting of 1,962 individuals with HCC, 1,430 control subjects and 159 family trios.
|
20676096 |
2010 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC.
|
22712471 |
2012 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48).
|
23803045 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings demonstrate that the presence of the G allele at rs17401966 of the KIF1B gene may decrease the risk for HCC and suggest that KIF1B may play a critical role in the development of HCC.
|
23634229 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis showed a significant association between KIF1B rs17401966 polymorphism and HCC.
|
24952890 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The SNP rs17401966 was genotyped using the TaqMan allelic discrimination assay in 414 intermediate or advanced hepatocellular carcinoma patients.
|
25153661 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Homozygous mutation of rs1081432 conferred a 2.68-fold risk of HCC (95% CI 1.35-5.34); however heterozygosity was not statistically significant. rs17401966 heterozygosity or homozygosity was not significantly associated with a increased risk of HCC.
|
25412941 |
2014 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
The gene-environment interaction between the KIF1B rs17401966 variant and alcohol consumption may contribute to the development of HCC in Chinese individuals.
|
27122668 |
2016 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
This meta-analysis suggested that KIF1B (rs17401966) polymorphism could decrease HCC risk in Chinese and in overall population, but not in non-Chinese.
|
29881295 |
2018 |
|
rs17401966
|
|
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
More well-designed studies with larger sample size and various ethnic groups and risk factors are needed to establish that KIF1B rs17401966 polymorphism is significantly associated with risk of HCC.
|
30947687 |
2019 |