|
rs8170
|
|
Epithelial ovarian cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
Common variant rs8170 and rare variants in ATG2B may be associated with EOC overall survival, although further study is needed.
|
26747452 |
2016 |
|
rs8170
|
|
Epithelial ovarian cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
|
20852633 |
2010 |
|
rs633862
|
|
Epithelial ovarian cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs633862
|
|
Epithelial ovarian cancer
|
|
0.720 |
GeneticVariation
|
BEFREE |
Supplementary to the previous GWAS, our study provides additional evidence on the prognostic value of the 9q34.2 rs633862 variant in EOC patients, and this variant may function by regulating the <i>ABO</i> mRNA expression.
|
29109911 |
2017 |
|
rs7643459
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs757210
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)).
|
23535730 |
2013 |
|
rs4525119
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs4286604
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs17329882
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
Additionally, haplotype analyses indicated that the haplotype block that contained rs17329882 was significantly associated with epithelial ovarian cancer risk, specifically with the serous epithelial ovarian cancer subtype.
|
28231729 |
2017 |
|
rs142091544
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We identified four novel loci with suggestive evidence of association with EOC (p < 1 × 10<sup>-6</sup> ), including rs4525119 (intronic to AKR1C3), rs7643459 (intronic to LOC101927394), rs4286604 (12 kb 3' of UGT2A2) and rs142091544 (5 kb 5' of WWC1).
|
31469419 |
2019 |
|
rs1413299
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1243180
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)).
|
23535730 |
2013 |
|
rs1192691
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs11782652
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
We validated the two loci at 3q25 and 17q21 that were previously found to have associations close to genome-wide significance and identified three loci newly associated with risk: two loci associated with all EOC subtypes at 8q21 (rs11782652, P = 5.5 × 10(-9)) and 10p12 (rs1243180, P = 1.8 × 10(-8)) and another locus specific to the serous subtype at 17q12 (rs757210, P = 8.1 × 10(-10)).
|
23535730 |
2013 |
|
rs11175194
|
|
Epithelial ovarian cancer
|
|
0.710 |
GeneticVariation
|
BEFREE |
Finally, we identify two EOC susceptibility loci at 9q22.33 (rs1413299 in COL15A1, P(meta) = 1.88 × 10(-8)) and 10p11.21 (rs1192691 near ANKRD30A, P(meta) = 2.62 × 10(-8)), and two consistently replicated loci at 12q14.2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages).
|
25134534 |
2014 |
|
rs1695
|
|
Epithelial ovarian cancer
|
|
0.030 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate whether GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G and NQO2 c.-102A>C polymorphisms, involved in xenobiotic detoxification pathways, alter outcomes of epithelial ovarian cancer (EOC) patients.
|
27586145 |
2016 |
|
rs1695
|
|
Epithelial ovarian cancer
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms such as ERCC1 8092C>A, ABCB1 2677G>T/A, GSTP1 I105V and GSTT1 polymorphisms may affect drug response, toxicity and survival in patient with EOC who received taxane- and platinum-based chemotherapy after surgery.
|
19203783 |
2009 |
|
rs1695
|
|
Epithelial ovarian cancer
|
|
0.030 |
GeneticVariation
|
BEFREE |
We tested in this study whether the GSTM1, GSTT1 and GSTP1 Ile105Val polymorphisms alter the risk of EOC.
|
22960333 |
2012 |
|
rs2032582
|
|
Epithelial ovarian cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms such as ERCC1 8092C>A, ABCB1 2677G>T/A, GSTP1 I105V and GSTT1 polymorphisms may affect drug response, toxicity and survival in patient with EOC who received taxane- and platinum-based chemotherapy after surgery.
|
19203783 |
2009 |
|
rs2032582
|
|
Epithelial ovarian cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642.
|
23917080 |
2013 |
|
rs144848
|
|
Epithelial ovarian cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
BRCA2 N372H Polymorphism and Risk of Epithelial Ovarian Cancer: An Updated Meta-Analysis With 2344 Cases and 9672 Controls.
|
26496279 |
2015 |
|
rs144848
|
|
Epithelial ovarian cancer
|
|
0.020 |
GeneticVariation
|
BEFREE |
There was no association between BRCA2 N372H and risk of borderline or invasive epithelial ovarian cancer.
|
14555511 |
2003 |
|
rs9909104
|
|
Epithelial ovarian cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Each copy of the minor allele in SHMT1 intron 5 A>G (rs9909104) was associated with epithelial ovarian cancer [odds ratio (OR), 1.2; 95% confidence interval (95% CI), 1.0-1.4; P trend = 0.02; FPRP = 0.16] and a 5-SNP SHMT1 haplotype was associated with decreased risk (P = 0.01; FPRP = 0.09).
|
18381459 |
2008 |
|
rs9609538
|
|
Epithelial ovarian cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
In analyses that included the 75 GWAS samples, the association between rs9609538 (OR = 0.84, P = 0.0007) and LMP serous EOC risk remained statistically significant at P < 0.0012 adjusted for multiple testing.
|
24190013 |
2014 |
|
rs927062
|
|
Epithelial ovarian cancer
|
|
0.010 |
GeneticVariation
|
BEFREE |
Other variants of interest included another in ARHGEF10L, rs10788679, which was associated with invasive serous EOC risk (OR = 1.07, p = 0.00026) and two variants in AKAP6 (A-kinase anchoring protein 6) which were associated with risk of invasive EOC (rs1955513, OR = 0.90, p = 0.00033; rs927062, OR = 0.94, p = 0.00059).
|
29979793 |
2018 |