|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Therefore, we conclude that homocysteine might affect the inflammatory status of patients, and the MTHFR 677C>T SNP could be a predictive factor of hyperhomocysteinemia in patients with RA.
|
19283524 |
2009 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Some considerations are put forward about hyperhomocysteinemia and the MTHFR 677C-->T mutation as cardiovascular risk factors.
|
15773669 |
2005 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To assess the prevalence of the C677T MTHFR genotype and the contribution of this genotype to hyper-tHcy in patients with IBD.
|
10446107 |
1999 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study provided evidence that hyperhomocysteinemia (HHcy) and MTHFR C677T polymorphism were associated with IS.
|
29390494 |
2017 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To determine the role of hyperhomocysteinemia in the pathogenesis of stroke in children with sickle cell disease (SCD), Hcy levels and C677T MTHFR genotype were determined in 40 patients homozygous for hemoglobin SS and compared with 197 healthy children.
|
10524453 |
1999 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects.
|
15820491 |
2005 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
To this purpose we have used platelets harvested from healthy volunteers or patients newly diagnosed with hyperhomocysteinemia with a C677T polymorphism of the MTHFR gene (MTHFR++).
|
24019484 |
2013 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subjects with the 677C-->T variant have impaired remethylation of Hcy to methionine that could determine hyperhomocysteinemia.
|
12471611 |
2003 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, with high-dose folate supplementation, the hyperhomocysteinemia in patients with ESRD does not seem to be caused by the 677C-->T mutation in the MTHFR gene.
|
10430972 |
1999 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated whether the MTHFR C677T and A1298C polymorphisms contribute to hyperhomocysteinemia and increase the risk factor for stroke.
|
16629766 |
2006 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Homozygosity for a common polymorphism in the MTHFR gene (C677T, Ala to Val) is associated with an increased risk of neural tube defects and hyperhomocysteinemia in individuals with low folate levels.
|
10695265 |
2000 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Association of vitamin B12 mediated hyperhomocysteinemia and methylenetetrafolate reductase (C677T) gene polymorphism with cognitive impairment: A population based study from North India.
|
30245375 |
2018 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hyperhomocysteinaemia and MTHFR C677T gene polymorphism in renal transplant recipients.
|
11420199 |
2001 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A cross-sectional study was performed in 120 maintenance HD patients to determine the prevalence of MTHFR C677T and A1298C mutations and their relative association to hyperhomocysteinemia and CVD.
|
12187094 |
2002 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
No association was found between Hhcy and C677T polymorphism in the MTHFR gene.
|
19083485 |
2008 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (RPLs), we assessed the association between the methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) C677T and A1298C and hyperhomocysteinemia in Tunisian women with idiopathic RPL.
|
16452733 |
2006 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
With an excellent sensitivity and a modest specificity, C677T could be a useful screening marker for severe HHcy.
|
24459043 |
2015 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with reduced enzyme activity, hyperhomocysteinaemia and increased risk for atherosclerosis in homozygotes.
|
11094304 |
2000 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
The C677T variant of methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the remethylation of homocysteine to methionine, is a frequent genetic cause of mild hyperhomocysteinemia among individuals with low folate status.
|
14608052 |
2003 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that most subjects with hyperhomocysteinemia > or = 40 micromol/liter in the general population have the C677T mutation combined with low folate status.
|
8903338 |
1996 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
MTHFR C677T polymorphism, folic acid and hyperhomocysteinemia in levodopa treated patients with Parkinson's disease.
|
15354385 |
2004 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
A thrombophilic evaluation was performed, revealing hyperhomocysteinemia and methylenetetrahydrofolate reductase (MTHFR) variants (C677T and A1298C).
|
24923843 |
2014 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Population frequency for homozygotic-TT alleles for C677T-MTHFR reductase and hyperhomocysteinemia is significantly higher in women under 40 years.
|
12553950 |
2003 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
Of the 58 patients, 30 had factor V Leiden mutation (5 homozygous, 25 heterozygous), 16 had prothrombin gene mutation, 24 had methylenetetrahydrofolate reductase C677T mutation (5 homozygous, 19 heterozygous), 18 had protein C deficiency, 17 had protein S deficiency, 14 had antithrombin III deficiency and 13 had hyperhomocysteinaemia.
|
25326427 |
2015 |
|
rs1217691063
|
|
Hyperhomocysteinemia
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, a genetic background such as the MTHFR C677T polymorphism responsible for hyperhomocysteinemia plays a role in the development of higher degree of steatosis, which in turn accelerates the progression of liver fibrosis in CHC.
|
15834927 |
2005 |