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rs2032582
|
|
Acute leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our results suggest that the ABCB1 G2677T and C3435T sequence variations may affect susceptibility to acute leukemia.
|
27706688 |
2016 |
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rs2032582
|
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
Three single nucleotide polymorphisms (SNPs) of the ABCB1 gene (rs 3213619 T129C, rs 2032582 G2677T and rs1045642 C3435T) were analysed in 70 Saudi children with ALL and 60 control subjects.
|
30508724 |
2019 |
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rs2032582
|
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
In the subgroup analysis, according to the type of leukemia, significant association was found between MDR1 G2677T polymorphism and myeloid leukemia but not lymphoblastic leukemia (TT vs. GG: OR = 0.66, 95% CI = 0.46-0.95, P = 0.026; TT vs.
|
24142546 |
2014 |
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rs2032582
|
|
Acute lymphocytic leukemia
|
|
0.030 |
GeneticVariation
|
BEFREE |
To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients.
|
18243305 |
2008 |
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rs2032582
|
|
Acute monocytic leukemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Impact of ABCB1 single nucleotide polymorphisms 1236C>T and 2677G>T on overall survival in FLT3 wild-type de novo AML patients with normal karyotype.
|
25155901 |
2014 |
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rs2032582
|
|
Agnosia for Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Assays of plasma concentrations of morphine and metabolites (morphine 3-glucuronide and morphine 6-glucuronide) were performed and common polymorphisms in four candidate genes [OPRM1 A118G rs1799971; P-glycoprotein (ABCB1) T3435C (rs1045642) and G2677T/A (rs2032582); COMT Val 158 Met (rs4680)] were analysed.Morphine was titrated by staff in the postanaesthesia care unit (PACU) and in the ward patient-controlled intravenous analgesia was used for 24 h.
|
29474345 |
2018 |
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rs2032582
|
|
Akathisia
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|
0.020 |
GeneticVariation
|
BEFREE |
The results suggest that individuals with the TT-TT/TA genotypes for the C3435T-G2677T/A polymorphisms of ABCB1 may be pre-disposed to a risk of akathisia.
|
28079463 |
2017 |
|
rs2032582
|
|
Akathisia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Marginal associations with akathisia (p=0.039 and p=0.042, respectively) and dystonia (p=0.013 and p=0.034, respectively) were observed for both G2677T/A and C3435T genotypes.
|
20060871 |
2010 |
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rs2032582
|
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Our results suggest that the ABCB1 3435C > T SNP, the 2677G > T/A SNP and 1236T/2677T/3435C haplotype are significantly associated with AD susceptibility.
|
27600024 |
2016 |
|
rs2032582
|
|
Alzheimer's Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
To evaluate the association of ATP-binding cassette subfamily B member 1 (ABCB1) genetic variants with the susceptibility to Alzheimer's disease (AD), we genotyped the rs1128503 (C1236T), rs2032582 (G2677T/A), and rs1045642 (C3435T) polymorphisms in a case-control sample (234 AD patients, 225 controls).
|
25273678 |
2014 |
|
rs2032582
|
|
Anemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
On evaluating higher order gene-gene interaction models by MDR analysis, CYP3A5*3; ABCB11236C>T and ABCB1 2677G>T/A; ABCB1 3435C>T and CYP1B1*3 showed significant association with treatment response, grade 2-4 anemia and dose delay/reduction due to neutropenia (P=0.024, P=0.004, P=0.026), respectively.
|
24704000 |
2014 |
|
rs2032582
|
|
Ankylosing spondylitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
ABCB1 gene rs2032582 and rs1128503 polymorphisms may be associated with the efficacy of etanercept in AS patients.
|
28151874 |
2017 |
|
rs2032582
|
|
Avascular Necrosis of Femur Head
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study investigated the relationship between genetic polymorphism in the MDR1 (C3435T, G2677T) and the development of steroid-induced osteonecrosis of femoral head (ONF) in Chinese systemic lupus erythematosus (SLE) patients.
|
18214345 |
2007 |
|
rs2032582
|
|
Balkan Nephropathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
The constitutional genotype frequencies of two SNPs (C3435T and G2677T) in the MDR1 gene in 112 healthy control subjects were investigated and compared with those of 96 patients with BEN.
|
14752243 |
2004 |
|
rs2032582
|
|
Behcet Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
The CC-GG binary genotype for C1236T-G2677T/A loci couple in particular may have a high degree of predisposition to BD (p=0.009; OR, 3.03; 95% CI, 1.41-6.54).
|
22705826 |
2012 |
|
rs2032582
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
|
22526155 |
2012 |
|
rs2032582
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Significant associations of rs2032582 SNP with tumor size, negative HER-2/neu status, and family history of breast carcinoma were found.
|
23093106 |
2012 |
|
rs2032582
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
The results of our quantitative synthesis suggest that there is no significant association between ABCB1 G2677T/A polymorphism and breast cancer risk in overall comparisons under four genetic models (heterozygote: OR = 1.01, 95% CI = 0.92-1.09, P = 0.90; homozygote: OR = 1.01, 95% CI = 0.65-1.55, P = 0.97; recessive model: OR = 1.06, 95% CI = 0.75-1.50, P = 0.76; and dominant model: OR = 0.98, 95% CI = 0.77-1.24, P = 0.85).
|
31679234 |
2019 |
|
rs2032582
|
|
Breast Carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
Whether ABCB1 polymorphisms including T-129C, A61G, C1236T, G2677T/A and C3435T polymorphisms could account for variations in the disposition of docetaxel and whether menopausal status at the time of diagnosis might interact with this effect were analysed in women receiving neoadjuvant chemotherapy for breast cancer (n=86).
|
20628376 |
2010 |
|
rs2032582
|
|
Bullous pemphigoid
|
|
0.020 |
GeneticVariation
|
BEFREE |
The results of the present study indicate that the G2677T/A polymorphism in the ABCB1 gene may affect the risk of developing BP.
|
28207188 |
2017 |
|
rs2032582
|
|
Bullous pemphigoid
|
|
0.020 |
GeneticVariation
|
BEFREE |
Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid.
|
29948283 |
2018 |
|
rs2032582
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1799971 and rs1323040 polymorphisms of the <i>OPRM1</i> gene and rs2032582 and rs1128503 polymorphisms of the <i>ABCB1</i> gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
|
30455395 |
2019 |
|
rs2032582
|
|
Carcinoma of lung
|
|
0.020 |
GeneticVariation
|
BEFREE |
The current results taken together suggest that, aside from other known causes of lung cancer, such as tobacco smoke, the existence of polymorphisms in the ABCB1 gene and, specifically, the presence of the G2677T mutation can be crucial in conferring susceptibility to lung cancer.
|
17120199 |
2006 |
|
rs2032582
|
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms such as ERCC1 8092C>A, ABCB1 2677G>T/A, GSTP1 I105V and GSTT1 polymorphisms may affect drug response, toxicity and survival in patient with EOC who received taxane- and platinum-based chemotherapy after surgery.
|
19203783 |
2009 |
|
rs2032582
|
|
Carcinoma, Ovarian Epithelial
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our study represents the largest analysis of ABCB1 SNPs and EOC progression and survival to date, but has not identified additional signals, or validated reported associations with progression-free survival for rs1128503, rs2032582, and rs1045642.
|
23917080 |
2013 |