rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We observed difference in SNPs in MDR1 gene C3435T p</span>olymorphism between breast cancer patients and healthy controls (chi(2) = 8.66, df = 2, p = 0.013).
|
17560460 |
2007 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A statistical association was observed between p53 codon 72 polymorphism and family history of breast cancer in both groups, as well as between MDR1 C3435T and smoking habits in cases (P<0.05).Gene polymorphisms vary by regions.
|
19885596 |
2009 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms of MDR1 C3435T and G2677A/T, but not C1236T, are associated with increased risk of breast cancer.
|
26838221 |
2016 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, there is limited evidence to indicate that the ABCB1 C3435T and rs2214102 G>A polymorphisms are associated with increased risk of breast cancer.
|
20625815 |
2011 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
MDR1 C3435T polymorphism in Mexican patients with breast cancer.
|
25062490 |
2014 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that C3435T MDR1 polymorphism was not associated with the susceptibility to breast cancer in the population studied.
|
19388849 |
2009 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the MDR1 C3435T polymorphism may contribute to individual susceptibility to breast cancer.
|
24070710 |
2013 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The present study was aimed to evaluate the possible effects of ABCB1 C3435T and ABCG2 C421A single nucleotide polymorphisms on clinical and pathological outcomes of Kurdish patients with breast cancer.
|
26700668 |
2016 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the ABCB1-C3435T gene polymorphism might be a genetic risk factor and a potential biomarker for breast cancer.
|
28039704 |
2017 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that C3435T polymorphism genotyping and menopausal status at the time of diagnosis might be useful when considering chemotherapy regimens including docetaxel in breast cancer patients.
|
20628376 |
2010 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that C3435T polymorphism and docetaxel exposure are involved in the response to neoadjuvant chemotherapy in breast cancer patients and may be useful to optimize individualized therapy.
|
23666532 |
2013 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that ABCB1 gene C3435T, G2677T/A variations and haplotype 3435T-1236T-2677T relate to the risk and clinical outcomes of breast carcinoma and may function as candidate molecular markers of anthracycline chemosensitivity in breast carcinoma.
|
22526155 |
2012 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To investigate the role of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms in breast cancer patients treated with 5-fluorouracil and cyclophosphamide-based neoadjuvant chemotherapy.
|
20638924 |
2010 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We aimed to determine the associations of genetic polymorphisms of excision repair cross-complementation group 1 (ERCC1) rs11615, xeroderma pigmentosum group D (XPD/ERCC2) rs13181, X-ray repair cross complementing group 1 (XRCC1) rs25487, XRCC3 rs1799794, and breast cancer susceptibility gene 1 (BRCA1) rs1799966 from the DNA repair pathway and multiple drug resistance 1 (MDR1/ABCB1) rs1045642 with response to chemotherapy and survival of non-small cell lung cancer (NSCLC) in a Chinese population.
|
24933103 |
2014 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that the T allele carrier of the 34</span>35 C/T polymorphism in the ABCB1 gene in combination with an estrogen receptor-negative status may be an important risk factor for breast cancer development in premenopausal women.
|
25730063 |
2015 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We examined the relevance of C3435T polymorphism in relation to breast cancer susceptibility, clinical and pathological characteristics of breast carcinoma, the therapeutic response and hematologic toxicities after anthracycline-based chemotherapy.
|
19752884 |
2010 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We have noted that the implication of C3435T</span> variant on the risk of breast cancer was ethnicity-dependent.
|
27580695 |
2016 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated a possible association between MDR1 gene C3435T polymorphism and its expression in Iranian breast cancer patients.
|
20082268 |
2010 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We investigated the incidence of C3435T polymorphisms at exon 26 in the MDR-1 gene in 92 women with breast cancer and potential association of altered genotypes with smoking and high body mass index in cancer development among patients.
|
17549370 |
2007 |
rs1045642
|
|
Breast Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
With regard to the clinical characteristics of BC, the <i>ABCC2</i> SNPs rs2273697 and rs717620 were found to be significantly associated with age at breast cancer diagnosis and breastfeeding status, while the <i>ABCB1</i> SNP rs1045642 was significantly associated with age at breast cancer diagnosis.
|
31391850 |
2019 |