|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827.
|
29084532 |
2017 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among the European CRC-susceptibility SNPs, rs4939827 in SMAD7 was associated with a significant decreased risk of Korean CRC (age-/gender-adjusted odds ratio [95% confidence interval]: additive model, 0.67 [95% CI, 0.47-0.95]; dominant model, 0.59 [95% CI, 0.39-0.91]). rs4779584 and rs10795668 were associated with CRC risk in females and males, respectively.
|
23875689 |
2015 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among those with CRC, the minor allele (G) in rs4939827 was significantly associated with poorer overall survival (hazards ratio, 1.20; 95% CI, 1.02-1.42).
|
23104301 |
2013 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Among those without distant disease at diagnosis, CRC-specific survival differed by genotype only for NSAID users: each minor allele of rs4939827 was associated with worse survival [hazard ratio (HR) = 2.67, 95% confidence interval (CI): 1.33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94).
|
21910156 |
2011 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Based on genome-wide association studies (GWAS) a linkage between several variants such as single nucleotide polymorphisms (SNPs) in intron 3 of SMAD7 (mothers against decapentaplegic homolog7) were, rs12953717, rs4464148 and rs4939827 has been noted for susceptibility to colorectal cancer (CRC).
|
25640388 |
2015 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian.
|
26579801 |
2015 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC.
|
26779637 |
2016 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
|
28467803 |
2017 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Micro RNA-375 and rs4939827 SNP in SMAD7 could be considered as potential markers for detecting and early diagnosing CRC patients.
|
28374902 |
2018 |
|
rs4939827
|
|
Colorectal Carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
|
rs4939827
|
|
Colorectal Carcinoma
|
T |
0.900 |
GeneticVariation
|
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |