|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common GC polymorphism within miRNA-146a precursor region (rs2910164) has been associated with the risk of various cancers despite the underlying mechanism is unclear.
|
22711332 |
2013 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A G>C polymorphism (rs2910164) in the miR-146a precursor sequence leads to a functional change associated with the risk for numerous malignancies.
|
21744077 |
2011 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A G>C polymorphism (rs2910164) in the miR‑146a precursor sequence leads to a functional change associated with a risk for various types of malignancy.
|
26323945 |
2015 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A G>C polymorphism, rs2910164, which is located in the sequence of miR-146a precursor, could alter mature miR-146a expression and has been suggested to influence cancer risk.
|
22455393 |
2012 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent study indicates that inflammation and abnormal immune responses may promote malignant progression in cancer development, indicating that inflammation-related polymorphisms such as miR-146a rs2910164 and miR-499 rs3746444 are crucial.
|
25108400 |
2014 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
However, limited evidence was found for association of miR-146a rs2910164 with cancer risk, and further well-designed studies with large sample size will be necessary to validate the effect of miR-146a rs2910164 on cancer susceptibility.
|
22952151 |
2012 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis indicated that rs2910164 C allele was associated with decreased cancer risk in Chinese population.
|
23750236 |
2013 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to the results of familial breast cancer studies, however, we found that the presence of the G allele of rs2910164 is associated with increased cancer risk, with an OR of 1.77 (95% CI 1.40-2.23).
|
26476291 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, miR-196a2 rs11614913, miR-146a rs2910164, and miR-499 rs3746444 are risk factors for cancer development, whereas mir-149 rs2292832 and miR-27a rs895919 are not associated with cancer risk.
|
24278149 |
2013 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, this meta-analysis suggests that has-miR-146a polymorphism (rs2910164) is associated with increased cancer susceptibility in Asians.
|
21947843 |
2012 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Investigating the association of rs2910164 with cancer predisposition in an Irish cohort.
|
28899898 |
2017 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
It was shown that 6 miRNAs SNPs (miR-608 rs4919510, miR-492 rs2289030, miR-378 rs1076064, miR-499 rs4919510, miR-149 rs2292832, miR-196a2 rs11614913) were associated with better cancer overall survival (OS) while let-7i rs10877887 was associated with poor OS; the homozygous and heterozygote genotype of miR-423 were related to poor cancer relapse-free survival (RFS) when compared with the wild genotype; miR-146 rs2910164 was linked to favorable cancer DFS while miR-196a2 rs11614913 was associated with poor DFS.
|
30619739 |
2018 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
MiR-146a rs2910164 polymorphism and overall cancer susceptibility were significantly uncorrelated in all genetic models.
|
29127520 |
2018 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
miR-146a plays important roles in cancer as it directly targets NUMB, an inhibitor of Notch signaling. miR-146a is reportedly regulated by a G>C polymorphism (SNP; rs2910164).
|
27824903 |
2016 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nevertheless, heterozygous genotype was found to be associated with higher GS, as well as with the presence of distant metastases. rs2910164 was also shown to be associated with cancer aggressiveness (p = 0.0067; ORGC = 2.22, 95 %CI 1.24-3.97; ORCC = 0.47, 95 %CI 0.13-1.68).
|
25084752 |
2014 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
No allelic variant was detected for hsa-mir-17 and hsa-mir-369, and allelic and genotype frequencies for miR-146a rs2910164 single-nucleotide polymorphism (SNP) were comparable with that of 155 controls from the same population, ruling out a role for genetic variations in these three miRNAs as major determinants in cancer predisposition of BRCA1/BRCA2-negative patients.
|
20810544 |
2010 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Over- or underexpression of miR-146a has been reported in several different human tumor types, and a polymorphism in its precursor form (pre-miR-146a rs2910164 G/C) has been recently studied in connection with cancer susceptibility.
|
23267167 |
2013 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of cancer.
|
23898084 |
2013 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent evidence suggests that the rs2910164 variant of miR-146a is associated with the development of certain types of malignancies.
|
26214637 |
2015 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Rs11614913 in miR-196a2 and rs2910164 in miR-146a are shown to associate with increased/decreased cancer risk.
|
21637771 |
2011 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analyses based on ethnicity, source of control group, and country indicated that there were strong associations between miRNA-146a rs2910164 and cancer risk.
|
29750042 |
2018 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
Subgroup analyses based on type of cancer and ethnicity were also performed, and results indicated that there was a strong association between miR-146a rs2910164 and overall cancer risk in Caucasian population under recessive model (OR = 1.274, 95%CI = 1.096-1.481, P = 0.002).
|
23226435 |
2012 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 CC genotype held a significantly higher risk of GC when compared to non-cancer subjects (adjusted odds ratio (OR) = 1.30, 95% confidence interval (CI) = 1.02-1.66, p =.03).
|
21073609 |
2010 |
|
rs2910164
|
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation
|
BEFREE |
The miRNA-146a rs2910164 C>G polymorphism may contribute to the development of cancer.
|
29983589 |
2018 |